Core Viewpoint - Defiance ETFs has launched the Defiance Daily Target 2X Long MRNA ETF (MRNX), aimed at providing active traders with leveraged exposure to Moderna, Inc. and its mRNA-based innovations in biotechnology and life sciences [1][2]. Investment Objective - The Fund aims to achieve daily investment results of 200% of the daily percentage change in the share price of Moderna, Inc., focusing solely on short-term trading strategies [3]. Underlying Stock - Moderna, Inc. is a biotechnology company specializing in the development of mRNA-based therapeutics and vaccines, addressing various disease areas including infectious diseases [4]. Fund Characteristics - The ETF is not a direct investment in Moderna, Inc. and is designed for knowledgeable investors who understand the risks associated with leveraged investments [5][6]. - The Fund's performance is subject to daily rebalancing, which may lead to significant differences in returns over periods longer than one day due to compounding effects [13][14]. Risks Associated with the Fund - The Fund's strategy involves swap agreements and options contracts, exposing it to risks similar to owning shares of Moderna, Inc., including potential declines in share price [9][11]. - The Fund is classified as non-diversified, which may increase sensitivity to adverse developments affecting Moderna, Inc. [18]. - High portfolio turnover is expected due to daily rebalancing, potentially increasing transaction costs and tax implications for investors [19].

Core Insights - The company has achieved significant breakthroughs in cancer treatment through its partnership with Merck, focusing on individualized therapies for melanoma and other cancers [2][4][6] - The phase two study for the melanoma treatment showed a 50% improvement in recurrence-free survival compared to existing treatments, with plans for a phase three study and potential FDA filing in 2027 [4][37] - The company is expanding its research into various cancers, including lung, kidney, bladder, gastric, and pancreatic cancers, with nine ongoing studies [6][7] Cancer Treatment Developments - The individualized treatment approach allows for tailored therapies based on the patient's specific cancer profile, with a turnaround time of approximately 30 days [3][4] - The safety profile of the new treatment is comparable to existing therapies, presenting no additional risks or side effects [7] - The company anticipates positive results from ongoing studies, which could lead to further FDA approvals and market launches [17][38] Vaccine Business and Market Strategy - The company expects 2027 to be a pivotal growth year, driven by opportunities in the $1.75 billion respiratory virus vaccine market in the EU and long-term partnerships in Latin America [8][39] - The company has three FDA-approved products and aims to diversify its portfolio with additional approvals expected this year [17][19] - Cost-cutting measures have been implemented, with $2 billion in costs reduced in the previous fiscal year, while still investing in future innovations [19][40] Collaboration and Innovation - The company is collaborating with Ricardati to advance treatments for rare metabolic disorders, leveraging mRNA technology [25][27] - The focus on innovation is critical for sustaining the industry, with a call for global contributions to support ongoing research and development [30][31][34] - The company emphasizes the importance of patent protection to encourage investment in new medicines, highlighting the long development timelines and high failure rates in clinical trials [33][34]

Core Insights - Moderna, Inc. is a biotechnology company based in Cambridge, Massachusetts, with a market cap of $17.2 billion, known for its messenger RNA medicines and COVID-19 vaccine, and is expanding its pipeline in various therapeutic areas [1] Performance Summary - Over the past 52 weeks, Moderna's shares have increased by 19.3%, outperforming the S&P 500 Index, which rose by 15.5%. Year-to-date, the stock is up 47.9%, while the S&P 500 has only gained 1.9% [2] - Despite this, Moderna has underperformed compared to the iShares Biotechnology ETF, which saw a 26.2% increase over the same period, although it has outperformed the ETF's 3.1% year-to-date return [3] Recent Developments - On January 21, shares surged by 15.8% following positive results from a five-year follow-up study of an experimental skin cancer vaccine in collaboration with Merck, showing a 49% reduction in recurrence or death risk for high-risk melanoma patients [5] Financial Outlook - Analysts project that Moderna's loss per share for the current fiscal year will narrow by 10.9% year-over-year to $7.90. The company has consistently exceeded consensus earnings estimates in the last four quarters [6] - The consensus rating among 24 analysts is a "Hold," with two "Strong Buy," 19 "Hold," one "Moderate Sell," and two "Strong Sell" ratings [6] Analyst Ratings and Price Targets - Edward Tenthoff from Piper Sandler Companies maintains a "Buy" rating with a price target of $63, indicating a potential upside of 44.3%. The current trading price is above the mean price target of $37.40, while the highest price target of $135 suggests a 209.1% premium [8]

分组1 - Arbutus Biopharma Corporation (ABUS) has experienced a decline of approximately 10% in its stock price over the past month due to a patent dispute with Moderna [1] - The company is involved in the biotechnology sector, focusing on innovative drug development and unique therapeutic approaches [1] - The analyst emphasizes the importance of evaluating the scientific basis of drug candidates, competitive landscape, clinical trial design, and market opportunities while considering financial fundamentals [1]

Whales with a lot of money to spend have taken a noticeably bullish stance on Moderna.Looking at options history for Moderna (NASDAQ:MRNA) we detected 26 trades.If we consider the specifics of each trade, it is accurate to state that 50% of the investors opened trades with bullish expectations and 38% with bearish.From the overall spotted trades, 4 are puts, for a total amount of $161,480 and 22, calls, for a total amount of $1,274,892.Predicted Price RangeAnalyzing the Volume and Open Interest in these con ...

报告导读： Moderna 个体化 mRNA 癌症疫苗 V940 在高危黑色素瘤中的 5 年随访结果 支持疫苗机制能提供持久免疫应答，为后续 III 期与注册推进提供了更充分的临床依据。 事件。 2026 年 1 月 21 日， Moderna 与默沙东联合披露个体化 mRNA 癌症疫苗 V940 （ mRNA-4157 ）联合 Keytruda 用于高危黑色素瘤辅助治疗的 IIb 期 5 年随访结果。该联合治疗方案在较长时间内维持了既往观察到的疗效水平，支持其能够诱导并维持相对持久的免疫应答。 核心读出数据支持疫苗机制能提供持久免疫应答。 KEYNOTE-942 研究结果显示 V940 联合 Keytruda 降低 49% 高危黑色素瘤患者复发或死亡风险，疗效 从 2 年随访时的 44% 提升至 3 年的 49% 并在 5 年随访时仍维持在 49% 。同时未发现新的安全性信号。 V940 的整体推进节奏在同类项目中较为靠前。 mRNA-4157 目前已开展 8 项 II/III 期临床研究，适应症覆盖黑色素瘤、非小细胞肺癌、膀胱癌及肾细胞癌 等多种实体瘤。其中黑色素瘤 III 期临床试验已完成入组，预计将于 ...

Core Insights - Moderna, Inc. (MRNA) and Novavax, Inc. (NVAX) were highly discussed stocks in the biotech, pharma, and healthcare sectors five years ago, indicating their significant market presence and investor interest [1]. Group 1 - The investing group Haggerston BioHealth, led by a biotech consultant with over five years of experience, provides detailed reports on more than 1,000 companies in the biotech, healthcare, and pharma industries [1]. - Haggerston BioHealth offers insights into catalysts for investment decisions, including buy and sell ratings, product sales forecasts, and integrated financial statements [1]. - The group also conducts discounted cash flow analysis and market-by-market analysis for major pharmaceutical companies [1].

Group 1 - Moderna, Inc. (MRNA) and Novavax, Inc. (NVAX) were highly discussed stocks in the biotech, pharma, and healthcare sectors five years ago [1] - The Haggerston BioHealth investing group provides insights for both novice and experienced biotech investors, including catalysts, buy and sell ratings, product sales forecasts, and integrated financial statements [1] Group 2 - The Haggerston BioHealth group has compiled detailed reports on over 1,000 companies in the biotech, healthcare, and pharma industries [1] - The group offers market-by-market analysis and discounted cash flow analysis for major pharmaceutical companies [1]

Moderna's Chief Medical Officer Jacqueline Miller, who led the development of the company's mRNA-based COVID-19 vaccine Spikevax, will step down effective March 2, the vaccine maker said on Friday. ...

CAMBRIDGE, MASSACHUSETTS / ACCESS Newswire / January 30, 2026 / Moderna, Inc. (NASDAQ:MRNA) today announced that David Berman, M.D., Ph.D. has been appointed as the Company's Chief Development Officer, beginning March 2, 2026. ...