Financial Performance - The net loss for the three months ended September 30, 2024, was 15.11million,comparedtoanetlossof8.19 million for the same period in 2023, indicating an increase in losses of approximately 84%[6] - Net loss for the nine months ended September 30, 2024, was 40,042,677,comparedtoanetlossof32,789,548 for the same period in 2023, representing a 22% increase in losses year-over-year[11] - The company reported a comprehensive loss of 15.0millionforthethreemonthsendedSeptember30,2024[7]AssetsandLiabilities−Totalcurrentassetsdecreasedfrom147.81 million as of December 31, 2023, to 116.72millionasofSeptember30,2024,representingadeclineofapproximately21142.82 million as of December 31, 2023, to 28.12millionasofSeptember30,2024,areductionofabout8028.53 million as of December 31, 2023, to 32.22millionasofSeptember30,2024,reflectinganincreaseofapproximately13394.26 million as of December 31, 2023, to 434.30millionasofSeptember30,2024,anincreaseofabout10119.80 million as of December 31, 2023, to 85.10millionasofSeptember30,2024,adeclineofapproximately2912.44 million, up 79% from 6.96millioninthesameperiodof2023[6]−Thecompanyanticipatesneedingadditionalfundinginthefuturetosupportongoingresearchanddevelopmentactivities,aswellascommercializationefforts[16]−Thecompany’sprincipalactivitiesincluderesearchanddevelopmentoftherapiesforimmune−mediatedandmetabolicdiseases[12]StockandCompensation−TheweightedaveragecommonsharesoutstandingforthethreemonthsendedSeptember30,2024,were59.53million,comparedto58.99millionforthesameperiodin2023[6]−Stock−basedcompensationfortheninemonthsendedSeptember30,2024,was6,710,160, slightly up from 6,553,112inthesameperiodof2023,reflectinga2.43,225,794, an increase from 789,217forthesameperiodin2023[57]MarketableSecuritiesandCashFlow−Thecompanyincurred75,351,884 in purchases of marketable securities during the nine months ended September 30, 2024, with no such purchases reported in the same period of 2023[11] - The company reported a net cash decrease of 74,702,987fortheninemonthsendedSeptember30,2024,comparedtoadecreaseof1,084,476 in the same period of 2023[11] - Cash and cash equivalents at the end of the period were 68,120,029,downfrom143,334,888 at the end of September 2023, indicating a decrease of approximately 52%[11] Debt and Financing - The Company has a current long-term debt obligation of 15millionundertheHerculesCreditFacilityasofSeptember30,2024[43]−Theeffectiveinterestrateontheloanwas13.31 million for the option to collaborate on reproxalap development[72] - AbbVie will pay the Company a 100millionupfrontcashpaymentandupto300 million in milestone payments related to the Collaboration Agreement[75] - The profit-sharing arrangement for the commercialization of reproxalap in the U.S. is set at 60% for AbbVie and 40% for the Company[75] Changes in Operations - As of September 30, 2024, the Company ceased development of the Helio Product Candidate, which may result in the reversion of related intellectual property rights[23] - The Company has not reported any changes to significant accounting policies during the nine months ended September 30, 2024[20] Tax and Valuation - The Company has a 100% valuation allowance against net deferred tax assets due to ongoing losses since inception[49] - The Company is subject to tax in the U.S. and is open to examination for tax years ended December 31, 2023, 2022, 2021, and 2020[50]