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Oric(ORIC) - 2024 Q3 - Quarterly Report
ORICOric(ORIC)2024-11-12 21:20

Financial Performance - ORIC Pharmaceuticals reported a net loss of 91.5millionfortheninemonthsendedSeptember30,2024,withanaccumulateddeficitof91.5 million for the nine months ended September 30, 2024, with an accumulated deficit of 526.5 million[44]. - Net loss for Q3 2024 was 34.6million,comparedtoanetlossof34.6 million, compared to a net loss of 25.5 million in Q3 2023, representing an increase of 9.1million(35.79.1 million (35.7%)[52]. - Net cash used in operating activities for the nine months ended September 30, 2024, was 84.6 million, compared to 61.4millioninthesameperiodof2023,anincreaseof61.4 million in the same period of 2023, an increase of 23.2 million (37.8%)[62]. - Net cash provided by financing activities for the nine months ended September 30, 2024, was 126.0million,comparedto126.0 million, compared to 85.2 million in the same period of 2023, an increase of 40.8million(47.840.8 million (47.8%)[64]. - The company has not generated any revenue to date and will require substantial additional capital to fund operations and product development[58]. Research and Development - The company has initiated a Phase 1b trial for ORIC-114, targeting advanced solid tumors with EGFR and HER2 alterations, and expects to report updated data in the first half of 2025[42]. - ORIC-944 demonstrated a clinical half-life of approximately 20 hours and a favorable safety profile in a Phase 1b trial for advanced prostate cancer, with ongoing combination studies initiated in 2024[42]. - ORIC-533 is in a Phase 1b trial for relapsed/refractory multiple myeloma, with initial data reported at the ASH annual meeting in December 2023[42]. - Research and development expenses are expected to increase significantly as the company advances its product candidates through clinical trials[48]. - Research and development expenses for Q3 2024 were 31.2 million, an increase of 8.8million(39.38.8 million (39.3%) from 22.4 million in Q3 2023[53]. - For the nine months ended September 30, 2024, research and development expenses totaled 82.1million,up82.1 million, up 21.4 million (35.2%) from 60.7millioninthesameperiodof2023[53].Thecompanyexpectsresearchanddevelopmentexpensestoincreasesubstantiallyasitcontinuestoinvestinproductcandidatesandclinicaltrials[54].GeneralandAdministrativeExpensesGeneralandadministrativeexpensesareanticipatedtorisesubstantiallyduetoincreasedheadcounttosupportongoingresearchanddevelopment[49].GeneralandadministrativeexpensesforQ32024were60.7 million in the same period of 2023[53]. - The company expects research and development expenses to increase substantially as it continues to invest in product candidates and clinical trials[54]. General and Administrative Expenses - General and administrative expenses are anticipated to rise substantially due to increased headcount to support ongoing research and development[49]. - General and administrative expenses for Q3 2024 were 7.1 million, an increase of 0.8million(12.70.8 million (12.7%) from 6.3 million in Q3 2023[55]. - For the nine months ended September 30, 2024, general and administrative expenses were 21.2million,up21.2 million, up 2.6 million (13.9%) from 18.7millioninthesameperiodof2023[56].CapitalandFundingThecompanyraised18.7 million in the same period of 2023[56]. Capital and Funding - The company raised 125 million through a private placement of 12.5 million shares at 10.00pershare,closingonJanuary23,2024[44].ApreviousprivateplacementonJune27,2023,raised10.00 per share, closing on January 23, 2024[44]. - A previous private placement on June 27, 2023, raised 85 million from the sale of 9.29 million shares at 7.00pershare[44].Thecompanyhasenteredintoan"atthemarket"salesagreementtosellupto7.00 per share[44]. - The company has entered into an "at the market" sales agreement to sell up to 200 million of common stock[44]. - Current cash and investments are expected to fund operations into late 2026, but additional funding will be necessary for future commercialization efforts[60]. - The company has cash equivalents and investments totaling 282.4millionasofSeptember30,2024,includinginterestbearingmoneymarketfundsandU.S.Treasurysecurities[67].MarketandEconomicConditionsInflationhasincreasedcostsrelatedtolabor,clinicaltrials,andmanufacturing,butthecompanydoesnotbelieveitsignificantlyimpacteditsresultsofoperations[69].Animmediate100basispointchangeininterestrateswouldnothaveamaterialeffectonthefairmarketvalueofthecompanyscashequivalentsandinvestments[67].Thecompanyinvestsinhighqualitymarketabledebtinstrumentswithmaturitydatesgenerallylessthantwoyearstopreserveprincipalandliquidity[67].CompanyClassificationandAccountingThecompanyhaselectednottousetheextendedtransitionperiodforemerginggrowthcompanies,whichmeansitsfinancialstatementsmaynotbecomparabletoothersthatdo[66].Thecompanywillremainanemerginggrowthcompanyuntilitexceeds282.4 million as of September 30, 2024, including interest-bearing money market funds and U.S. Treasury securities[67]. Market and Economic Conditions - Inflation has increased costs related to labor, clinical trials, and manufacturing, but the company does not believe it significantly impacted its results of operations[69]. - An immediate 100 basis point change in interest rates would not have a material effect on the fair market value of the company's cash equivalents and investments[67]. - The company invests in high-quality marketable debt instruments with maturity dates generally less than two years to preserve principal and liquidity[67]. Company Classification and Accounting - The company has elected not to use the extended transition period for emerging growth companies, which means its financial statements may not be comparable to others that do[66]. - The company will remain an emerging growth company until it exceeds 1.235 billion in annual revenue or meets other specified criteria[66]. - The company is classified as a smaller reporting company and may continue to take advantage of scaled disclosures as long as certain revenue and stock value thresholds are met[66]. - There have been no significant changes in the company's critical accounting policies since the last annual report[65]. Strategic Focus - ORIC Pharmaceuticals is focused on developing therapies that counter resistance mechanisms in cancer, leveraging expertise in hormone-dependent cancers and precision oncology[41].