Sales Performance - Fourth-quarter 2024 net sales increased to 748.8million,a2.32.893 billion, a decline of 1.9%, while organic net sales declined by 1.5%[9] - Fourth-quarter 2024 net sales for the Proprietary Products segment increased to 613.9million,withorganicnetsalesgrowthof4.5748.8 million, a 2.4% increase from 732.0millioninthesameperiodof2023[21]−OrganicnetsalesforthethreemonthsendedDecember31,2024,were756.0 million, reflecting a positive impact from currency translation rates[25] Earnings Per Share (EPS) - Fourth-quarter 2024 reported-diluted EPS was 1.78,adeclineof2.71.82, a decline of 0.5%[6] - Full-year 2024 adjusted-diluted EPS was 6.75,adeclineof16.56.69, with guidance for 2025 projected between 5.97and6.17, indicating a potential decrease of 10.8% to 7.8%[26] - Full-year 2025 adjusted-diluted EPS is expected to be in the range of 6.00to6.20, including an estimated headwind of approximately 0.23fromforeigncurrencyexchangerates[11]CashFlowandCapitalExpenditures−Operatingcashflowforfull−year2024was653.4 million, a decline of 15.9%, while free cash flow decreased by 33.3% to 276.4million[10]−OperatingcashflowforthetwelvemonthsendedDecember31,2024,was653.4 million, down from 776.5millionin2023[29]−Capitalexpendituresforfull−year2025areexpectedtobe275 million, supporting capacity expansions and investments in Contract Manufacturing facilities[11] - Capital expenditures for the twelve months ended December 31, 2024, were 377.0million,comparedto362.0 million in 2023[29] Profitability Metrics - Gross profit for the twelve months ended December 31, 2024, was 998.5million,down11.51,129.2 million in 2023, resulting in a gross profit margin of 34.5% compared to 38.3%[21] - Adjusted operating profit for the three months ended December 31, 2024, was 162.8million,reflectinga1.8159.9 million in the same period of 2023[22] Restructuring and Working Capital - The company recorded a restructuring expense of 3.0millionforthethreemonthsendedDecember31,2024,relatedtooptimizingitslegalstructure[23]−WorkingcapitalasofDecember31,2024,was987.7 million, down from $1,264.6 million in 2023[31] Market Performance - The Biologics market unit experienced high-single digit organic net sales growth, driven by self-injection device platforms[4]