Financial Performance - Revenues for 2024 were 42,879million,aslightincreaseof042,857 million in 2023[144]. - GAAP operating income increased by 7% to 7,337millionin2024from6,859 million in 2023, resulting in a GAAP operating income margin of 17.1%[144]. - Adjusted operating income (non-GAAP measure) was 9,707millionin2024,adecreaseof19,810 million in 2023, with an adjusted operating income margin of 22.6%[144]. - Organic revenue growth was flat at 0% in 2024, with COVID-19 related product sales declining to 0.10billionfrom0.33 billion in 2023[146]. - The company reported a GAAP diluted earnings per share of 16.53for2024,upfrom15.45 in 2023[193]. Segment Performance - Life Sciences Solutions segment revenues decreased by 3% to 9,631millionin2024,primarilyduetoreducedCOVID−19relatedrevenue[157].−AnalyticalInstrumentssegmentrevenuesincreasedby37,463 million, driven by strong growth in the electron microscopy business[158]. - Specialty Diagnostics segment revenues grew by 2% to 4,512million,supportedbygrowthinimmunodiagnosticsandtransplantdiagnostics[159].−LaboratoryProductsandBiopharmaServicessegmentrevenuesincreasedby123,157 million, with flat organic revenues due to decreased demand for COVID-19 related activities[161]. Cash Flow and Debt - The company generated free cash flow of 7,324millionin2024,comparedto7,014 million in 2023, reflecting a year-over-year increase[175]. - As of December 31, 2024, the company's cash and cash equivalents decreased to 4,009millionfrom8,077 million in 2023[172]. - Total debt as of December 31, 2024, was 31,275million,downfrom34,917 million in 2023[172]. - Net cash provided by operating activities was 8,667millionin2024,anincreasefrom8,406 million in 2023[175]. Acquisitions and Investments - The company executed strategic acquisitions, including The Binding Site Group and CorEvitas, enhancing its diagnostic and biopharma service capabilities[150][151]. - The acquisition of Olink Holding AB (publ) in 2024 utilized 3,130millionincash,contributingtothecompany′sinvestingactivities[179].−Thecompanyrepurchased4,000 million of its common stock in 2024, which included 7.4 million shares[183]. - The company expects capital expenditures for property, plant, and equipment in 2025 to be between 1,400millionand1,700 million[182]. Tax and Valuation - The company expects its GAAP effective tax rate for 2025 to be between 9% and 11%, with an adjusted tax rate of approximately 11.5%[166]. - The company's liability for unrecognized tax benefits was 0.52billionatDecember31,2024,downfrom0.54 billion at December 31, 2023[202]. - The company's tax valuation allowance decreased to 1.04billionatDecember31,2024,from1.32 billion at December 31, 2023[204]. Goodwill and Intangible Assets - Goodwill and indefinite-lived intangible assets totaled 45.85billionand1.24 billion, respectively, as of December 31, 2024[197]. - The company recorded definite-lived intangible asset impairments of 0.01billionin2023[201].−Thecompanyperformedquantitativegoodwillimpairmenttestsandfoundnoimpairmentsattheendofthetenthfiscalmonthof2024[200].−Thecompanyusesassumptionsrelatedtorevenueandoperatingincomemargingrowthratesforimpairmenttestingofgoodwillandindefinite−livedintangibleassets[197].CurrencyandExchangeRateImpact−A102.05 billion[210]. - A 10% depreciation in year-end 2024 non-functional currency exchange rates related to forward currency-exchange contracts would result in an unrealized loss of 32million[211].−A1016 million[212]. Credit Facilities - The company has a revolving credit facility providing up to 5,000million,withnoborrowingsoutstandingasofDecember31,2024[174].−Thetotalestimatedfairvalueofthecompany′sdebtwas28.53 billion at December 31, 2024[208].