Financial Performance - Net cash used in operations increased by 8,802,000to41,767,000 for 2024, compared to 32,965,000for2023[188]−Netcashusedinoperationsincreasedby1,909,000 to 32,965,000in2023comparedto31,056,000 in 2022, driven by increased research and development expenses[191] - Net cash provided by financing activities was 31,227,000in2024,adecreasefrom40,033,000 in 2023, primarily due to changes in transactions[190] - In 2023, the company received 40,033,000infinancing,upfrom10,000,000 in 2022, with 30,000,000fromaconvertiblelineofcreditand10,000,000 from stock purchase warrants[192] Research and Development - Research and development expenses for 2024 were 36,571,000,adecreaseof13.832,130,000 in 2023[174] - Clinical program expenses increased to 29,079,000in2024from23,942,000 in 2023, primarily due to NAVIGATE clinical trial activities[175] - Research and development expenses are charged as incurred, with significant costs related to the NAVIGATE clinical trial and third-party contract research organizations[199] Cash Position and Financing - As of December 31, 2024, the company had 15.1millioninunrestrictedcashandcashequivalents,plus6 million available under a line of credit[187] - The company has raised a net total of 314.5millionfrompublicandprivateofferingssinceitsinception[187]−ThecompanybelievesithassufficientcashtofundoperationsthroughAugust2025,butwillrequireadditionalfinancingthereafter[187]ClinicalTrials−TheNAVIGATEtrialiscurrentlytheonlyactiveclinicaltrial,withnoplansorfundingforadditionaltrialsatthistime[173]−Thecompanyhasengagedoutsidevendorsforclinicaltrialservices,whicharetypicallycancellableon30daysnotice[195]OperatingExpenses−Generalandadministrativeexpensesdecreasedby1.35,942,000 in 2024 from 5,862,000in2023[178]−Stock−basedcompensationismeasuredatgrantdatefairvalueandrecognizedovertheserviceperiod,withestimatesforpotentialforfeituresincluded[200]−ThecompanyenteredintoanoperatingleaseforofficespaceinNorcross,GA,withanaveragerateofapproximately4,250 per month, effective from March 1, 2022[193] Market Risks and Losses - The company has incurred significant operating losses since inception and cannot assure future revenue generation[171] - The company is not exposed to significant market risks as of December 31, 2024, and 2023[201] - The company has not created any off-balance sheet entities that could materially affect liquidity or capital resources[196]