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Blueprint Medicines(BPMC) - 2025 Q1 - Quarterly Results

Revenue Performance - AYVAKIT net product revenues reached 149.4millioninQ12025,representinga61149.4 million in Q1 2025, representing a 61% year-over-year growth[1] - Total revenues for Q1 2025 reached 149.413 million, a 55.5% increase from 96.116millioninQ12024[19]Productrevenue,netwas96.116 million in Q1 2024[19] - Product revenue, net was 149.413 million, compared to 92.525millioninthesamequarterlastyear,indicatingstronggrowth[19]FinancialGuidanceThecompanyraisedAYVAKITnetproductrevenueguidancefor2025to92.525 million in the same quarter last year, indicating strong growth[19] Financial Guidance - The company raised AYVAKIT net product revenue guidance for 2025 to 700 - 720million,aimingfor720 million, aiming for 2 billion by 2030[4] Expenses - Research and development expenses for Q1 2025 were 91.9million,upfrom91.9 million, up from 88.2 million in Q1 2024, reflecting increased investment in priority programs[9] - Selling, general and administrative expenses increased to 95.8millioninQ12025from95.8 million in Q1 2025 from 83.6 million in Q1 2024, driven by commercialization activities[9] - Research and development expenses increased to 91.890millionfrom91.890 million from 88.191 million year-over-year, reflecting ongoing investment in innovation[19] - Selling, general and administrative expenses rose to 95.807million,upfrom95.807 million, up from 83.557 million in Q1 2024, indicating increased operational costs[19] Net Income - Net income for Q1 2025 was 0.5million,significantlylowerthan0.5 million, significantly lower than 89.1 million in Q1 2024, primarily due to a one-time gain in the previous year[9] - Net income for Q1 2025 was 496,000,asignificantdecreasefrom496,000, a significant decrease from 89.136 million in Q1 2024[19] - Net income per share (basic) was 0.01,downfrom0.01, down from 1.45 in the previous year, highlighting a decline in profitability[19] Cash and Investments - Cash, cash equivalents, and investments totaled 899.8millionasofMarch31,2025,comparedto899.8 million as of March 31, 2025, compared to 863.9 million at the end of 2024[9] Research and Development Initiatives - The company initiated two proof-of-concept studies for BLU-808, targeting allergic rhinoconjunctivitis and chronic urticaria[4] - The company presented 12 poster and two oral data presentations at the AAAAI/WAO conference, showcasing long-term data from the PIONEER study[4] - The company continues to focus on expanding its product offerings and enhancing its research capabilities to drive future growth[19] Strategic Goals - Blueprint Medicines plans to achieve reimbursement of AYVAKIT in at least 20 countries overall[9] - Blueprint Medicines aims to reduce cash burn year-over-year in 2025 while advancing its prioritized programs[5]