Revenue Performance - Total revenue for the three months ended March 31, 2025, was 54.1million,a352.4 million in the same period of 2024, driven by a 1.8millionincreaseinproductrevenue[128].−Productrevenueaccountedfor9350.4 million in Q1 2025 from 48.6millioninQ12024,a493.0 million in Q1 2025 from 102.0millioninQ12024,primarilyduetoa1542.1 million, down from 49.6millioninQ12024,reflectinga7.5 million decrease [130]. - The company expects research and development expenses to stabilize over time following the recent decreases [130]. Cash Flow and Financial Position - As of March 31, 2025, the company had cash and cash equivalents of 246.9million[146].−ForthethreemonthsendedMarch31,2025,netcashusedinoperatingactivitieswas29.0 million, a 210% increase from 9.3millioninthesameperiodof2024[147][149].−Thecompanyreportedanetcashusedininvestingactivitiesof2.4 million for the three months ended March 31, 2025, down from 5.5millionin2024[150].−NetcashusedinfinancingactivitiesforthethreemonthsendedMarch31,2025was4.7 million, compared to a net cash provided of 6.9millioninthesameperiodof2024[151][152].−AsofMarch31,2025,thecompany’sinvestmentportfolio,includingcashandcashequivalents,totalsapproximately246.9 million [161]. Debt and Obligations - The company issued 218.5millioninaggregateprincipalamountof2029Notes,withapproximately23.4 million used for capped call transactions [144]. - Future material cash obligations total 462.5million,including390.5 million in debt obligations [154]. Interest Income and Expenses - Interest income increased by 73% to 2.3millioninQ12025from1.3 million in Q1 2024, attributed to higher cash balances [133]. - Interest expense rose by 114% to 4.5millioninQ12025from2.1 million in Q1 2024, primarily due to the addition of the 2029 Notes [134]. Foreign Currency and Risks - The company experienced a foreign currency translation exchange loss of 0.7millionforthethreemonthsendedMarch31,2025,comparedtoalossof0.2 million in 2024 [159]. - The company plans to enter into additional foreign currency forward contracts to mitigate currency fluctuation risks [160]. Other Financial Activities - The net gain from changes in fair value of contingent considerations and acquisition-related holdbacks was 4.8millioninQ12025,downfrom15.4 million in Q1 2024, a decrease of 69% [135]. - Wuxi employees exercised options contributing a total capital of CNY 88.0 million (approximately 12.3million)forapotentialIPOinChina[141].−AsofMarch31,2025,thecompanyhadraisedgrossproceedsof90.2 million through the ATM Agreement, with approximately $59.8 million available for future issuances [140].