Financial Performance - Total revenues for Q1 2025 were 7.5million,adecreasefrom17.1 million in Q1 2024, primarily due to a one-time revenue recognition of 6millioninthepreviousyear[8].−ThenetlossforQ12025was20.7 million, or 0.25pershare,comparedtoanetlossof11.5 million, or 0.16pershare,inQ12024[8].−Thecompanyexpectstotalrevenuesfor2025tobeintherangeof64 million to 68million[13].ResearchandDevelopment−ResearchandDevelopmentexpensesincreasedto12.9 million in Q1 2025 from 11.2millioninQ12024,drivenbyhighersalariesandlabsuppliescosts[8].−CodexisplanstoachievepilotscaleproductionofGLP−gradesiRNAmaterialusingtheECOSynthesisInnovationLabin2025[7].ContractsandCollaborations−Codexissecureditsfirstrevenue−generatingcontractforECOSynthesis™manufacturingservicesinMarch2025[5].−ThecompanywillpresentattheTIDESUSAannualmeeting,showcasingitsligasetechnologyandcollaborationswithleadingCDMOs[3][7].CashandInvestments−AsofMarch31,2025,Codexishad59.8 million in cash, cash equivalents, and short-term investments, sufficient to fund operations through positive cash flow expected by the end of 2026[8][13]. - The company maintained its investment in non-marketable equity securities at 2,798million[21].AssetsandLiabilities−Totalassetsdecreasedfrom149,011 million as of December 31, 2024, to 128,887millionasofMarch31,2025,representingadeclineofapproximately13.598,772 million to 77,808million,adecreaseofabout21.211,920 million to 6,442million,adropofapproximately46.082,084 million to 79,258million,areductionofabout3.423,648 million to 20,901million,adeclineofabout11.728,905 million to 29,186million,anincreaseofabout1.066,927 million to 49,629million,adecreaseofapproximately25.9(562,806) million to $(583,494) million, indicating a worsening financial position[21]. Product Performance - Product gross margin improved to 55% in Q1 2025 from 49% in Q1 2024, attributed to a shift towards more profitable products[8]. Leadership Changes - Codexis appointed new board members with extensive experience in biopharmaceuticals and CDMO sectors to strengthen its leadership[5].