Omeros(OMER) - 2025 Q1 - Quarterly Results

Exhibit 4.2 OMEROS CORPORATION and COMPUTERSHARE TRUST COMPANY, NATIONAL ASSOCIATION as Trustee SECOND SUPPLEMENTAL INDENTURE Dated as of May 14, 2025 C R O S S R E F E R E N C E TA B L E * | Tru | s | t | I | n | d | e | n | tu | r | e | | | | | | | | | | | | | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | A | c | t | I | n | d | e | n | tu | r | e ...