Revenue Performance - Revenue increased by 41.2million,or41142.2 million for the nine months ended September 30, 2023, compared to 101.0millionforthesameperiodin2022[126].−InstrumentrevenueforthethreemonthsendedSeptember30,2023,increasedby23.3 million, or 203%, to 34.7million,drivenbythesaleof52Reviosystems[135].−Productrevenueincreasedby43.9 million, or 51%, to 129.9millionfortheninemonthsendedSeptember30,2023,comparedto85.9 million for the same period in 2022[148]. - Instrument revenue increased by 42.7million,or10085.3 million for the nine months ended September 30, 2023, driven by the sale of 129 Revio systems[150]. - Consumables revenue increased by 0.8million,or516.9 million for the three months ended September 30, 2023, compared to 16.1millionforthesameperiodin2022[136].−Consumablesrevenueincreasedby1.3 million, or 3%, to 44.6millionfortheninemonthsendedSeptember30,2023,attributedtohigherRevioconsumablessales[151].ProfitabilityandExpenses−Grossprofitmargindecreasedto300.7 million, or 2%, to 43.2millionfortheninemonthsendedSeptember30,2023,withagrossmarginof3026.8 million, or 12%, to 246.9millionfortheninemonthsendedSeptember30,2023,comparedto220.1 million for the same period in 2022[132]. - Research and development expense decreased by 7.8million,or5142.6 million for the nine months ended September 30, 2023, compared to 150.4millionforthesameperiodin2022[155].−Sales,generalandadministrativeexpenseincreasedby8.0 million, or 7%, to 123.8millionfortheninemonthsendedSeptember30,2023,drivenbyincreasedmarketingexpenses[156].−Merger−relatedexpensestotaled9.0 million for the nine months ended September 30, 2023, primarily due to the acquisition of Apton[157]. Cash and Investments - Cash, cash equivalents, and short-term investments were 767.8millionatSeptember30,2023,representinga1767.8 million, slightly down from 772.3millionasofDecember31,2022[164].−CashusedinoperatingactivitiesfortheninemonthsendedSeptember30,2023,was201.6 million, compared to 202.6millionforthesameperiodin2022[171][172].−CashprovidedbyinvestingactivitiesfortheninemonthsendedSeptember30,2023,was71.2 million, up from 35.7millionin2022[169][174].−CashprovidedbyfinancingactivitiesduringtheninemonthsendedSeptember30,2023,was190.5 million, significantly higher than 8.8millionin2022[169][175].AcquisitionsandMergers−ThecompanyenteredintoamergeragreementwithAptonBiosystemsonAugust2,2023,issuingapproximately6.3millionsharesofcommonstockuponclosing[131].−Adeferredincometaxbenefitof10.7 million was recognized for the nine months ended September 30, 2023, related to the Apton acquisition[163]. - The company paid approximately 100.9millionincashand9.0millionsharesofcommonstockasmilestoneconsiderationrelatedtotheOmniomeacquisitioninOctober2023[167].−Thecompanyisobligatedtopay25.0 million to former Apton equity holders upon achieving 50millioninrevenuefromahighthroughputsequencerusingApton′stechnology[168].−Thechangeinfairvalueofcontingentconsiderationwas14.0 million during the nine months ended September 30, 2023, related to the Omniome acquisition milestone[159]. Other Income - Other income, net increased by 23.0million,or178424.3 million for the nine months ended September 30, 2023, compared to 1.3millionforthesameperiodin2022[146].−OtherincomefortheninemonthsendedSeptember30,2023,was24.3 million, a significant increase from 1.3millioninthesameperiodof2022,primarilyduetoinvestmentincome[162].ProductLaunches−ThecompanycommencedcommercialshipmentsoftheOnsoshort−readsequencinginstrumentinAugust2023,followingthelaunchofReviointhefirstquarterof2023[123].−TheinstalledbaseofReviosystemsreached129bytheendofthequarter,reflectingstrongcustomerdemandforthenewproduct[126].FinancialSensitivity−Ahypothetical100basis−pointchangeininterestrateswouldaffectthefairvalueoftheinvestmentportfoliobyapproximately2.4 million[185]. - The company has maintained a full valuation allowance on net deferred tax assets of its U.S. entities, indicating uncertainty in realizing these assets[163].