Stock Performance and Market Context - Johnson & Johnson (JNJ) stock lost about 7% in 2024, underperforming the S&P 500 index, which gained 23% for the year [1] - JNJ stock declined from 155inearlyJanuary2024to144 by the end of the year [6] - Over the last four years, JNJ stock returns were 11% in 2021, 6% in 2022, -9% in 2023, and -5% in 2024 [6] Business Performance in 2024 - J&J saw an uptick in its medical devices business, driven by recent acquisitions, with electrophysiology and cardiovascular sales trending higher [3] - Market share increased for blockbuster drugs like Darzalex, Erleada, and Tremfya, with Darzalex generating around 3billioninquarterlysales[3]−BiosimilarcompetitionimpactedkeydrugslikeImbruvica,whichsawa71.7 billion, Shockwave Medical for 13.1billion,YellowJerseyfor1.25 billion, and Proteologix for 850milliontoexpanditsMedTechandpharmaceuticalbusinesses[4]−Cashpositiondeclinedfrom23 billion in 2023 to 20billionasofSeptember2024,whileoveralldebtincreasedfrom29 billion to 36billion[5]−Thecompanyincreaseditsdividendby4.24.96 in 2024 and spent 2billiononsharerepurchasesinthefirstthreequarters[5]Outlookfor2025−Stelara,atop−sellingdrugwith11 billion in annual sales in 2023, faces biosimilar competition in Europe and the U.S., potentially leading to a meaningful decline in sales [8][9] - J&J temporarily paused the use of its heart device Varipulse due to reports of neurovascular events, which was expected to generate over 1billioninannualsales[9]−NewdrugslikeCarvyktiandSpravatoaregainingmarketshare,atrendexpectedtocontinuein2025[10]−PotentialFDAapprovalforNipocalimabandfasttrackdesignationforPosdinemabcouldprovidegrowthopportunities[11]ValuationandPeerComparison−JNJstockisestimatedtohaveavaluationof172 per share, over 20% above its current levels of $142, based on a 17x forward P/E multiple [7] - The stock is trading at under 14x forward expected earnings, suggesting potential headwinds are largely priced in [12]