Natural Alternatives International and CarnoSyn® Brands Publish Clinical Research Demonstrating TriBsyn™ Delivering Exceptional Bioavailability, Increased Efficiency and Paresthesia Elimination

Core Insights - Natural Alternatives International, Inc. (NAI) and CarnoSyn® Brands announced positive clinical trial results for TriBsyn™, demonstrating enhanced bioavailability and efficiency of beta-alanine while eliminating paresthesia, a common side effect [1][5]. Product Overview - TriBsyn™ is a carnosine booster derived from CarnoSyn® beta-alanine, utilizing proprietary Hydro Oleo technology for higher bioavailability and potency, allowing for effective dosages at lower volumes [2][5]. - The formulation enables absorption through multiple pathways, including direct cellular uptake and traditional gastrointestinal routes, enhancing delivery at both cellular and systemic levels [2]. Clinical Study Details - The study evaluated the bioavailability, pharmacokinetics, and tolerability of a 400 mg Hydro Oleo encapsulated beta-alanine complex (TriBsyn™) designed to reduce paresthesia [3]. - A randomized, double-blind, single-dose, three-treatment, three-way crossover study was conducted in healthy older adults, showing that TriBsyn™ (400 mg) achieved a nearly 4.5-fold increase in circulating beta-alanine plasma concentrations compared to 400 mg and a 1.3-fold increase compared to 1200 mg of conventional beta-alanine [3][7]. Sensory Side Effects Assessment - Sensory side effects were assessed using Visual Analogue Score (VAS) and Qualitative Light Symptoms Inventory (QLSI), with no paresthesia reported in the TriBsyn™ group, while conventional beta-alanine groups exhibited increasing paresthesia with dose [4]. - TriBsyn™ recorded a VAS score of 0.62, indicating almost absent symptoms, compared to scores of 2.02 and 4.01 for conventional beta-alanine at 400 mg and 1200 mg, respectively [4]. Market Implications - The results confirm TriBsyn™ as a significant advancement in beta-alanine supplementation, providing scientifically proven claims to improve muscle vitality, working capacity, and cognitive performance, particularly beneficial for the active aging population and those with plant-based diets [5][6]. - NAI's new "paresthesia-free" TriBsyn™ powder allows the company to expand its product offerings within dietary supplements, medical food, and fortified food products [6].