Core Insights - Voyager Therapeutics has made significant advancements in its anti-tau programs targeting Alzheimer's disease, with VY7523 in clinical trials and VY1706 in IND-enabling studies [2] - The company generated approximately 80millioninnon−dilutivefundingin2024,whichisexpectedtosupportoperationsthroughmid−2027[2]−CollaborationrevenuesdecreasedsignificantlyinQ42024andforthefullyearcomparedto2023,primarilyduetoreducedrevenuefromNeurocrineandNovartisagreements[5][8]FinancialResults−CollaborationrevenueforQ42024was6.3 million, down from 90.1millioninQ42023;totalcollaborationrevenuefor2024was80.0 million compared to 250.0millionin2023[5][18]−NetlossforQ42024was34.5 million, compared to a net income of 56.4millioninQ42023;thefullyearnetlosswas65.0 million versus a net income of 132.3millionin2023[14][19]−Researchanddevelopmentexpensesincreasedto35.6 million in Q4 2024 from 25.8 million in Q4 2023, with total R&D expenses for 2024 at 127.4 million compared to 92.2millionin2023[14][19]UpcomingMilestones−VY1706isexpectedtofileforINDin2026,withadditionaldatatobepresentedattheADPDconferenceinApril2025[6][7]−InitialtauPETimagingdataforVY7523isanticipatedinthesecondhalfof2026[6]−INDfilingsforpartneredgenetherapiesrelatedtoGBA1Parkinson′sandFriedreich′sataxiaareexpectedin2025[7]CashPosition−AsofDecember31,2024,Voyagerhadcash,cashequivalents,andmarketablesecuritiestotaling332.4 million, an increase from $230.9 million in 2023 [14][19] - The company's cash runway is projected to extend into mid-2027, not including potential milestone payments from existing partnerships [9][14]