TREMFYA® (guselkumab) is the first and only IL-23 inhibitor to significantly reduce both the signs and symptoms and the progression of structural damage in adults living with active psoriatic arthritis

Core Insights - TREMFYA® (guselkumab) has shown clinically meaningful and statistically significant efficacy in treating active psoriatic arthritis (PsA) in a Phase 3b study, achieving its primary endpoint of ACR20 and a major secondary endpoint related to structural damage progression at 24 weeks [1][2] - The drug is the first fully-human, dual-acting monoclonal antibody approved for PsA, targeting IL-23 and binding to CD64, which is crucial in the pathogenesis of immune-mediated diseases [1][4] - The APEX study will continue to assess the long-term efficacy of TREMFYA® over three years, with results expected to be presented at medical congresses [1][2] Company Overview - Johnson & Johnson maintains exclusive worldwide marketing rights for TREMFYA®, which is approved in multiple regions including the U.S., Europe, Canada, and Japan for treating moderate-to-severe plaque psoriasis and active PsA [5] - The company emphasizes the importance of early treatment to prevent irreversible joint damage in PsA patients, highlighting TREMFYA®'s unique ability to inhibit structural damage [1][3] Industry Context - Psoriatic arthritis is a chronic, inflammatory disease that can lead to significant joint damage and comorbidities, affecting patients typically between the ages of 30 and 50 [3][4] - The prevalence of PsA among individuals with plaque psoriasis is notable, with studies indicating that up to 30% may develop the condition [4]