ZyVersa Therapeutics Announces Published Data Showing Inflammasome ASC Inhibitor IC 100 Decreases Microglial Inflammasome Activation and Alpha-Synuclein That Contribute to Neurodegeneration in Parkinson's Disease

Core Insights - ZyVersa Therapeutics, Inc. has announced new data supporting its Inflammasome ASC Inhibitor IC 100 as a potential treatment to slow the progression of Parkinson's disease [1][2] - The study published in npj Parkinson's Disease reveals that IC 100 blocks microglial inflammasome activation and reduces neurotoxic alpha-synuclein accumulation, both of which are critical in the progression of Parkinson's disease [2][7] Company Overview - ZyVersa is a clinical stage specialty biopharmaceutical company focused on developing first-in-class drugs for inflammatory and renal diseases, with a strong position in the inflammasome space [10] - The company is preparing to initiate proof-of-concept studies for IC 100 in animal models later this year [3] Study Findings - The research indicates that targeting inflammasomes and ASC specks may also be beneficial for treating Lewy body dementia and Alzheimer's Disease [5] - IC 100 is a humanized IgG4 monoclonal antibody designed to inhibit the inflammasome adaptor protein ASC, which plays a role in the inflammatory response [6] Market Context - Parkinson's Disease affects over 10 million people globally, with the current treatment market valued at $6.6 billion in 2024 and projected to reach$13.3 billion by 2034 [7] - Current treatments primarily address symptoms rather than the underlying disease, highlighting the potential market opportunity for disease-modifying therapies like IC 100 [7]