Core Insights - BioCryst Pharmaceuticals reported first-quarter sales of 145.50million,a52.7126.87 million [1] - The growth was primarily driven by Orladeyo's net revenue of 134.2million,whichincreasedby45.3 million year over year, compared to 88.9millioninthesamequarterofthepreviousyear[1]FinancialPerformance−Thenetincomeforthefirstquarterof2025was32 thousand, or 0.00pershare,asignificantimprovementfromanetlossof35.4 million, or 0.17pershare,inthefirstquarterof2024[2]−Operatingincomeforthefirstquarterof2025was21.2 million, compared to an operating loss of 14.5millionforthesameperiodin2024[3]−Non−GAAPoperatingincome,excludingstock−basedcompensation,was42.6 million for the first quarter of 2025, compared to a non-GAAP operating loss of 0.8millioninthefirstquarterof2024[3]GuidanceandOutlook−BioCrystraisedits2025revenueoutlookforOrladeyotobetween580 million and 600million,upfromthepreviousestimateof535 million to 550million[4]−Thecompanynowanticipatesfull−year2025operatingexpensestobebetween440 million and 450million,anincreasefromthepriorguidanceof425 million to 435million[4]−Theexpectationforachievingnetincomeandpositivecashflowshasbeenacceleratedto2025,previouslyanticipatedfor2026[5]−Positivecashflowisdefinedastheimprovementincashandequivalentsfromyear−end2024toyear−end2025,excludinga75 million prepayment made in April 2025 [5] Market Reaction - Following the announcement, BCRX stock closed up by 23.50% to $11.03 [5]