Financial Data and Key Metrics Changes - Total reported revenue in Q4 2024 was 708million,adecreaseof4150 million, representing a 21% adjusted EBITDA margin, compared to 195millionintheprioryearperiod[13][26]−Fullyear2024totalreportedrevenuewas2.8 billion, including 2.3billioninnon−respiratoryrevenue,withadjusteddilutedearningspershareat1.85 [18][19] Business Line Data and Key Metrics Changes - Labs business, approximately 50% of total revenues, achieved 4% growth on a reported and constant currency basis, excluding COVID and non-core revenue [11] - Immunohematology business within transfusion medicine grew 4% in Q4 2024, while donor screening revenue declined by 40% [23] - Q4 respiratory revenue declined 18% year-over-year, with 44millioninCOVIDrevenue[24]MarketDataandKeyMetricsChanges−Fourthquarterconstantcurrencyrevenueperformancewasledbythe"otherregion"(Japan,AsiaPacific,LatinAmerica),whichgrew13100 million in annualized savings, with 50millionexpectedinthefirsthalfof2025[36]Management′sCommentsonOperatingEnvironmentandFutureOutlook−Managementexpressedoptimismabouttheprogressmadeinthesecondhalfof2024andexpectscontinuedmomentuminto2025[17][30]−Thecompanyanticipatesfullyear2025totalreportedrevenuebetween2.6 billion and 2.81billion,withadjustedEBITDAbetween575 million and 615million[31]−ManagementnotedthattheriskofadditionalVBPpressureinChinahaslargelypassed,butcompetitiveintensityhasincreased[48][82]OtherImportantInformation−ThecompanyfinishedQ42024with98 million in cash and 198millioninborrowingsonits800 million revolver [28] - Adjusted free cash flow for Q4 2024 was 68million,representing4550 million of cost savings from previously announced initiatives will benefit the first half of 2025, with additional savings expected from procurement [55] Question: Respiratory revenue expectations - Management expects respiratory revenue to grow in the low single digits for 2024 and 2025, with a focus on flu, RSV, and strep [59] Question: Long-term margin expansion - Management targets adjusted EBITDA margins greater than 25% over the next two to three years, with progress expected as direct procurement savings materialize [87] Question: Timing for Savanna trials - Management confirmed that Savanna trials started in January, with expectations for market entry later in the year if trials are successful [98] Question: Donor screening revenue guidance - Management expects U.S. donor screening revenue to be 40millionto50 million in 2025, down significantly from 2024 [100]