Financial Data and Key Metrics Changes - For the full year 2022, the company achieved nearly 10% core revenue growth and adjusted earnings per share growth, with 8% core revenue growth in the base business [9][10] - The fourth quarter sales were 8.4billion,with7.52.87, up 6.5% year-over-year [11][14] - The gross profit margin for the fourth quarter was 59%, and the operating margin was 27.4%, reflecting a 100 basis point increase [13] Business Line Data and Key Metrics Changes - The Biotechnology segment reported a 1% decline in revenue, but core revenue grew 4%, driven by strong demand in bioprocessing [15] - The Life Sciences segment saw reported revenue growth of 8% and core revenue growth of 13%, with double-digit growth in instruments [18] - The Diagnostics segment's reported revenue increased by 3%, with core revenue growth of 7.5%, led by Cepheid's mid-teens growth [19] Market Data and Key Metrics Changes - Core revenue growth in North America and Western Europe was approximately 10%, while China experienced low single-digit growth due to COVID-19 impacts [11][12] - The company anticipates lower testing volumes in China to continue through the first quarter of 2023 before gradually recovering [12] - The Environmental & Applied Solutions segment reported a 1% revenue growth and 5.5% core revenue growth, with strong demand in water quality [24][25] Company Strategy and Development Direction - The company is well-positioned for future growth, focusing on durable business models and attractive end markets, supported by strong free cash flow and balance sheet capacity for strategic M&A opportunities [8][9] - Investments in research and development exceeded 1.7billionin2022,aimedatacceleratinginnovationandenhancinggrowthtrajectories[9][10]−ThecompanyplanstoupdateitsbasebusinesscorerevenuegrowthdefinitiontoexcludeCOVID−19−relatedtestingimpacts[27]Management′sCommentsonOperatingEnvironmentandFutureOutlook−Managementexpressedconfidenceinthecompany′sabilitytonavigatesupplychainchallengesandinflationarypressures,withexpectationsforhighsingle−digitcoregrowthinthebasebusinessfor2023[28]−ThecompanyanticipatesadeclineintotalcorerevenuegrowthduetolowerdemandforCOVID−19testing,vaccines,andtherapeutics[28]−ManagementhighlightedtheimportanceoftheDanaherBusinessSystemindrivingoperationalefficiencyandmarketsharegains[26]OtherImportantInformation−Thecompanyhasrestructureditsreportingsegments,separatingtheLifeSciencessegmentintotwonewsegments:BiotechnologyandLifeSciences[14]−ThecompanyexpectsCOVID−19−relatedvaccineandtherapeuticrevenuetodropsignificantlyin2023,fromapproximately800 million in 2022 to around $150 million [16] Q&A Session Summary Question: Inventory situation and bioprocessing expectations - Management expects mid-single-digit growth in the base business for Q1, with non-COVID bioprocessing anticipated to be low single digits due to inventory adjustments [31][33] Question: Instrument demand expectations - Management noted that instrument businesses saw low double-digit growth in 2022 but expect moderation to mid-single digits towards the end of the year [35] Question: China market outlook - Management anticipates high single-digit decline in Q1 for China, with expectations for recovery throughout the year [41][70] Question: M&A environment - Management characterized the current M&A environment as improving, with active funnels and a strong balance sheet, indicating readiness for value-creating acquisitions [73] Question: Non-COVID testing expectations for Cepheid - Management expressed optimism about non-COVID testing growth, with over 20% growth observed in the fourth quarter [77]