Company Performance - Aligos Therapeutics reported a quarterly loss of $3.07 per share, which was worse than the Zacks Consensus Estimate of a loss of $2.15, representing an earnings surprise of -42.79% [1] - The company posted revenues of $1.27 million for the quarter ended September 2024, exceeding the Zacks Consensus Estimate by 26.90%, but down from $2.15 million in the same quarter last year [2] - Over the last four quarters, Aligos has surpassed consensus EPS estimates two times and topped revenue estimates just once [2] Stock Performance - Aligos Therapeutics shares have declined approximately 40.8% since the beginning of the year, contrasting with the S&P 500's gain of 21.2% [3] - The current Zacks Rank for Aligos is 4 (Sell), indicating expectations of underperformance in the near future [6] Future Outlook - The consensus EPS estimate for the upcoming quarter is -$1.47 on $1 million in revenues, and for the current fiscal year, it is -$8.20 on $2.6 million in revenues [7] - The outlook for the Medical - Biomedical and Genetics industry is relatively strong, ranking in the top 38% of over 250 Zacks industries, suggesting potential for better performance compared to lower-ranked industries [8]

Financial Performance - The company reported net losses of $49.1 million and $59.8 million for the nine months ended September 30, 2024 and 2023, respectively, with an accumulated deficit of $535.9 million as of September 30, 2024[104]. - The company has incurred net losses and negative cash flows from operations since its formation, with no revenue from product sales reported[104]. - The company expects to continue incurring significant expenses and increasing operating losses over the next several years due to ongoing research and development activities[104]. - Revenue from collaborations decreased by $2.1 million (99%) for the three months ended September 30, 2024, and by $7.0 million (96%) for the nine months ended September 30, 2024, primarily due to the completion of the Amended Agreement with Merck[114]. - General and administrative expenses decreased by $1.8 million (28%) for the three months ended September 30, 2024, compared to the same period in 2023, and decreased by $6.5 million (27%) for the nine months ended September 30, 2024[117]. - Total operating expenses for the three months ended September 30, 2024, were $21.400 million, a decrease of $0.910 million (4%) compared to $22.310 million in the same period of 2023[113]. - Interest income, net decreased by $0.548 million (55%) for the three months ended September 30, 2024, compared to the same period in 2023, primarily due to a general decrease in market interest rates[118]. - Other income, net increased by $0.452 million (838%) for the three months ended September 30, 2024, compared to the same period in 2023, due to changes in fair value of common warrants[118]. - For the nine months ended September 30, 2024, the company utilized $62.3 million in cash for operating activities, primarily due to a net loss of $49.1 million[129]. - The net cash used in operating activities for the same period in 2023 was $56.3 million, resulting from a net loss of $59.8 million[129]. - The company reported a net decrease in cash, cash equivalents, and restricted cash of $100.3 million for the nine months ended September 30, 2024[128]. - The company has no committed external sources of funds and may need to raise additional capital, which could dilute existing ownership interests[126]. - The company expects to incur substantial additional funds to achieve its business objectives, as its drug candidates may not achieve commercial success[125]. - The company’s future capital requirements will depend on various factors, including the costs of research, development, and commercialization of its drug candidates[123]. Research and Development - The company is developing ALG-000184, a Capsid Assembly Modulator for chronic hepatitis B (CHB), which demonstrated HBV DNA suppression in 60% of subjects by Week 48 and 90% in HBeAg-positive subjects by Week 72[100]. - ALG-055009, a thyroid hormone receptor beta agonist for metabolic dysfunction associated steatohepatitis (MASH), showed statistically significant reductions in liver fat of up to 46.2% at Week 12 in Phase 2a trials[102]. - The company has initiated Phase 1 clinical trials for ALG-097558, a small molecule coronavirus 3CL protease inhibitor, which has shown to be at least 6-fold more potent than nirmatrelvir against SARS-CoV-2 variants[103]. - The Phase 1b study of ALG-000184 indicated potentially best-in-class antiviral activity with no viral breakthrough observed in HBeAg-negative subjects[101]. - The company plans to submit a new Phase 2 protocol for ALG-000184 in Q1 2025, following FDA clearance for a Phase 1 drug-drug interaction study[101]. - The Phase 2a HERALD study for ALG-055009 included 102 subjects and demonstrated a favorable tolerability profile with no evidence of clinical hyper/hypothyroidism[102]. - Research and development expenses for the three months ended September 30, 2024, increased by $0.9 million to $16.774 million compared to $15.867 million in the same period of 2023, primarily due to increased clinical study costs[115]. - Total direct research and development expenses for the nine months ended September 30, 2024, were $28.529 million, up from $22.179 million in the same period of 2023, reflecting a 29% increase[109]. - The company expects research and development expenses to increase substantially in connection with ongoing clinical development activities related to its drug candidates[120]. Funding and Capital Requirements - The company is exploring external funding options, including approximately $13.8 million from NIH awards to support the development of ALG-097558[104]. - The company has no material changes to its contractual obligations and commitments as of September 30, 2024[133]. - The company did not have any off-balance sheet arrangements during the periods presented[134]. - The company may need to relinquish valuable rights to its technology or future revenue streams if it raises additional funds through collaborations or licensing arrangements[127].

Financial Performance - Aligos reported a net loss of $19.3 million for Q3 2024, with a basic and diluted net loss per share of $(3.07), compared to a net loss of $18.0 million and $(10.37) per share in Q3 2023[7]. - Cash, cash equivalents, and investments totaled $74.9 million as of September 30, 2024, down from $135.7 million as of December 31, 2023, indicating a decrease of approximately 44.8%[6]. - Total operating expenses for Q3 2024 were $21.4 million, compared to $22.3 million in Q3 2023, indicating a slight decrease[15]. - Aligos believes its current cash balance is sufficient to fund planned operations through the end of 2025[6]. Research and Development - Research and development (R&D) expenses increased to $16.8 million in Q3 2024 from $15.9 million in Q3 2023, primarily due to higher third-party expenses for clinical trials[8]. - Aligos is progressing ALG-000184 for chronic hepatitis B (CHB) towards a Phase 2 study next year, with positive feedback from the FDA regarding its primary efficacy endpoint[3]. - The company expects to begin externally funded clinical studies for ALG-097558 in COVID subjects later this year, with three additional clinical studies planned for 2024[5]. Clinical Trial Results - The company announced positive topline HERALD data for ALG-055009, showing placebo-adjusted median relative reductions in liver fat of up to 46.2%[2]. - Up to 70% of subjects treated with ALG-055009 achieved a ≥30% relative reduction in liver fat compared to baseline[4]. General and Administrative Expenses - General and administrative (G&A) expenses decreased to $4.6 million in Q3 2024 from $6.4 million in Q3 2023, reflecting a reduction in third-party expenses including legal costs[9].

Core Insights - Aligos Therapeutics reported significant progress in its clinical programs and financial results for Q3 2024, highlighting the potential of its drug candidates for liver and viral diseases [1][2]. Recent Business Progress - The company achieved a milestone with positive topline HERALD data for ALG-055009, showing placebo-adjusted median relative reductions in liver fat of up to 46.2% [2][4]. - ALG-000184 is advancing towards a Phase 2 study for chronic hepatitis B (CHB), with positive feedback from the FDA and the National Medical Products Administration in China [3][4]. - ALG-097558, a pan-coronavirus protease inhibitor, is set to begin three additional clinical studies in 2024 [5]. Financial Results for Q3 2024 - Cash, cash equivalents, and investments totaled $74.9 million as of September 30, 2024, down from $135.7 million at the end of 2023, with sufficient funds projected to support operations through the end of 2025 [6]. - The net loss for Q3 2024 was $19.3 million, or $(3.07) per share, compared to a net loss of $18.0 million, or $(10.37) per share, in Q3 2023 [7]. - Research and development expenses increased to $16.8 million from $15.9 million year-over-year, primarily due to higher third-party clinical trial expenses [8]. Drug Candidates Overview - ALG-000184 is positioned as a potential first-/best-in-class treatment for CHB, with ongoing Phase 1a/1b studies and plans for future registration studies [3]. - ALG-055009 demonstrated significant efficacy in reducing liver fat and improving lipid profiles, with favorable tolerability [4]. - ALG-097558 is being evaluated in high-risk COVID patients, with studies sponsored by the AGILE University of Liverpool and the NIAID [5].

Company Announcement - Aligos Therapeutics, Inc. has appointed David Perry as Vice President of Business Development, effective immediately [1] - The company aims to maximize the potential of its pipeline, including ALG-055009, which has recently shown positive topline data [1] Leadership Background - David Perry brings over 20 years of experience in the life sciences industry, focusing on corporate strategy, business development, and investment management [1][2] - His previous role was Senior Director of Business Development at Sangamo Therapeutics, where he led significant licensing deals [1][2] - Perry has also held positions at Apexigen Inc. and Sumitomo Chemical, contributing to M&A and early-stage investments [2] Company Overview - Aligos Therapeutics is a clinical stage biopharmaceutical company focused on developing therapies for liver and viral diseases [3] - The company employs a science-driven approach to advance its pipeline targeting metabolic dysfunction-associated steatohepatitis (MASH) and high unmet medical needs such as hepatitis B and coronaviruses [3]

SOUTH SAN FRANCISCO, Calif., Sept. 30, 2024 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS), a clinical stage biopharmaceutical company focused on improving patient outcomes through best-in-class therapies for liver and viral diseases, today announced that members of management will participate at two investor conferences being webcast in October: H.C. Wainwright 8th Annual MASH Virtual Conference Fireside Chat at 3:00pm ET/12:00pm PT on October 7, 2024 H.C. Wainwright 5th Annual Viral Hepatiti ...

The Medical group has plenty of great stocks, but investors should always be looking for companies that are outperforming their peers. Is Aligos Therapeutics, Inc. (ALGS) one of those stocks right now? A quick glance at the company's year-to-date performance in comparison to the rest of the Medical sector should help us answer this question.Aligos Therapeutics, Inc. is a member of our Medical group, which includes 1019 different companies and currently sits at #4 in the Zacks Sector Rank. The Zacks Sector R ...

Aligos Therapeutics, Inc. (ALGS) closed the last trading session at $14.48, gaining 5.3% over the past four weeks, but there could be plenty of upside left in the stock if short-term price targets set by Wall Street analysts are any guide. The mean price target of $108.33 indicates a 648.1% upside potential.The mean estimate comprises three short-term price targets with a standard deviation of $57.74. While the lowest estimate of $75 indicates a 418% increase from the current price level, the most optimisti ...

SOUTH SAN FRANCISCO, Calif., Aug. 15, 2024 (GLOBE NEWSWIRE) -- Aligos Therapeutics, Inc. (Nasdaq: ALGS, “Aligos”, “Company”), a clinical stage biopharmaceutical company focused on developing novel therapeutics to address unmet medical needs in liver and viral diseases, today announced that it will effect a 1-for-25 reverse stock split of its shares of common stock. The reverse stock split will become effective at 12:01 am ET on Monday, August 19, 2024. The Company’s common stock is expected begin trading on ...

Aligos Therapeutics, Inc. (ALGS) appears an attractive pick, as it has been recently upgraded to a Zacks Rank #2 (Buy). This rating change essentially reflects an upward trend in earnings estimates -- one of the most powerful forces impacting stock prices.A company's changing earnings picture is at the core of the Zacks rating. The system tracks the Zacks Consensus Estimate -- the consensus measure of EPS estimates from the sell-side analysts covering the stock -- for the current and following years.Individ ...