道指涨20.20点，涨幅为0.04%，报50135.87点；纳指涨207.46点，涨幅为0.90%，报23238.67点；标普 500指数涨32.51点，涨幅为0.47%，报6964.82点。 | 美股指数 △ | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 道琼斯工业 | | 纳斯达克指数 | | 标普500 | | | | 50135.87 | | 23238.67 | | 6964.82 | | | | +20.20 +0.04% +207.46 +0.90% | | | | +32.52 +0.47% | | | | < W | | 道琼斯工业平均(DJI) | | | | | | | | 02-09 16:20:01 | | | | | | 50135.87 | | 昨收 | 50115.67 | 成交额 | 0 | | | 20.20 | 0.04% | 中心 | 50047.79 | 成交量 | 0 | | | 上 涨 | 11 | 母 習 | 0 | 下 跌 | 19 | | | 最高价 | 50219.40 | 市盈率 ...

Core Viewpoint - Ascentage Pharma has received investigational new drug (IND) application clearance for its novel BTK-targeted protein degrader, APG-3288, from the China Center for Drug Evaluation (CDE), following similar clearance from the U.S. FDA, marking a significant milestone in its clinical development for patients with relapsed/refractory hematologic malignancies [1][6]. Group 1: Drug Development and Clinical Trials - APG-3288 is set to enter a multicenter, open-label Phase I study to evaluate its safety, tolerability, pharmacokinetic profile, and preliminary efficacy in patients with relapsed/refractory hematologic malignancies [2]. - The IND clearance for APG-3288 enhances Ascentage Pharma's pipeline in hematologic malignancies, complementing existing products like Olverembatinib and Lisaftoclax, which have already been approved in China [5]. Group 2: Mechanism of Action and Innovation - APG-3288 utilizes Ascentage Pharma's proprietary PROTAC technology to induce the degradation of BTK, overcoming resistance associated with conventional BTK inhibitors by blocking the BCR-BTK signaling axis at its source [4]. - The drug is designed to provide a novel therapeutic strategy by inducing rapid and sustained degradation of both wild-type BTK and multiple BTK mutants, addressing the urgent clinical need for new treatment options in B-cell malignancies [3][4]. Group 3: Company Background and Strategy - Ascentage Pharma is a global biopharmaceutical company focused on developing innovative therapies for cancer, with a strong presence in hematologic malignancies and a diverse pipeline of drug candidates [8]. - The company has established partnerships with leading biotechnology and pharmaceutical firms, enhancing its research and development capabilities and expanding its global reach [11].

Core Insights - Coeur Mining's stock has experienced a significant decline, falling 6.1% recently and 24% since reaching an all-time high of nearly $26 per share on January 27 [1] - The drop in Coeur Mining's stock price is attributed to falling gold and silver prices, with gold prices dropping from an all-time high of $5,419.80 per ounce to below $4,660, and silver prices falling from $116.58 to $76.67 [3][4] Company Performance - Coeur Mining's current stock price is $19.47, with a market capitalization of $13 billion [5] - The stock has a gross margin of 31.80% and a trailing P/E ratio of 30, but a forward P/E ratio of less than 10 due to expected earnings growth of 90% next year, resulting in a PEG ratio of about 0.3 [6][7] Market Context - The decline in precious metal prices is seen as a potential buying opportunity for Coeur Mining stock, as analysts suggest that despite the current price drop, the long-term outlook remains positive [8]

随着贵金属价格自连续三日下跌中回升，金矿和银矿股周二普遍反弹。黄金矿企Newmont上涨4.0%， Barrick Mining上涨4.3%，Agnico Eagle Mines上涨3.8%，Franco-Nevada上涨2.1%，Kinross Gold上涨 4.4%，New Gold上涨5.2%。白银矿企Coeur Mining上涨6.0%，Endeavour Silver上涨5.7%，Pan American Silver上涨5.7%，Silvercorp Metals上涨5.0%。现货黄金价格一度上涨6.2%，现货白银价格一度上涨 12%。 本文源自：金融界AI电报 ...

Key Takeaways U.S. stocks rose in January, setting up five momentum picks spanning tech, beauty, mining and semiconductors.AI data centers and cloud upgrades are boosting demand for Amphenol solutions, Seagate storage and KLA tools.Ulta Beauty and Coeur Mining post solid growth outlooks, with earnings estimates rising across five picks. U.S. stock markets started 2026 on a positive note after an astonishing rally in the last three years. In January, the three major stock indexes — the Dow, the S&P 500 and t ...

热门中概股盘初涨跌互现，纳斯达克中国金龙指数跌0.40%，哔哩哔哩、阿里巴巴、网易跌超2%，百 度、京东跌超1%；小鹏汽车涨超2%。 PayPal大跌超18%。 编辑丨瑜见 矿业股大涨，科尔黛伦矿业涨超8%，泛美白银涨超6%。 存储概念走强，西部数据涨超4%，闪迪涨超5%。 科技股多数上涨，英特尔涨超4%，谷歌涨逾1%。 2月3日，美股三大指数开盘涨跌不一，截至发稿，纳指涨0.36%，道指涨0.22%，标普500指数涨 0.20%。 | 名称 | 现价 | 涨跌 涨跌幅 | | --- | --- | --- | | 道琼斯工业平均 | 49515.08 | 107.42 0.22% | | 纳斯达克指数 | 23676.02c | 83.91 0.36% | | 标普500 | 6990.31 | 13.87 0.20% | ...

Coeur Mining Inc (NYSE:CDE) is one of the most undervalued stocks to buy and hold for 5 years. On January 27, Coeur Mining Inc (NYSE:CDE) announced that it had gained shareholder support for the proposed merger with New Gold Inc. The two companies voted on the merger during their respective special meetings, in which 99.22% of New Gold shareholders supported the transaction. As a result, New Gold shareholders will receive 0.4959 shares of Coeur common stock for each New Gold share they hold. Coeur Mining ( ...

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Core Viewpoint - The article discusses a significant drop in gold and silver prices, attributed to the market's reaction to Trump's nomination of Kevin Warsh as the Federal Reserve Chairman, which is perceived as a hawkish choice, leading to a stronger dollar and reduced appeal for dollar-denominated commodities [1][3][14]. Group 1: Market Reaction - Gold prices fell sharply after reaching a historical high, with a drop of nearly 13%, marking the largest intraday decline since the early 1980s [1][11]. - Silver, which had previously surged past $120, saw its price plummet over 35%, the largest recorded drop in history [1][11]. - The entire metals market was affected, with copper also experiencing a significant decline of nearly 6% after reaching record highs [1][11]. Group 2: Federal Reserve Policy Expectations - The market's sell-off was driven by a sudden shift in expectations regarding Federal Reserve policy, with Warsh's nomination seen as a signal against aggressive rate cuts [3][4]. - Analysts noted that Warsh's hawkish reputation, despite recent support for rate cuts, contributed to a rebound in the dollar, making dollar-denominated commodities less attractive [4][18]. Group 3: Market Vulnerability - The dramatic price drop highlighted the extreme vulnerability of the precious metals market, which had been characterized by crowded long positions and record levels of bullish options buying [7][8]. - Analysts indicated that the market had become highly speculative, with a potential for a "gamma squeeze" that could exacerbate price movements [20][22]. Group 4: Technical Indicators and Market Sentiment - Prior to the crash, technical indicators suggested that gold and silver were overbought, with the Relative Strength Index (RSI) for gold reaching a historic high of 90 [24]. - Despite the sharp decline, both gold and silver recorded substantial gains for January, with gold up approximately 9% and silver over 10% [24]. Group 5: Mining Stocks and ETFs - The drop in precious metals prices led to significant declines in major mining companies, with stocks like Newmont and Barrick Mining falling over 10% [26]. - Silver ETFs experienced even greater losses, with some funds seeing declines of over 60%, marking their worst single-day performance [26]. Group 6: Future Outlook - Some analysts view the recent pullback as a healthy correction, suggesting that the rapid price increases necessitated a consolidation phase [26]. - There are indications that buying opportunities may arise as prices stabilize, particularly for silver, which is expected to benefit from industrial demand and supply shortages [26].

每经AI快讯，1月31日，美股三大指数收盘集体下跌，道指跌0.36%，1月累涨1.73%；纳指跌0.94%，1 月累涨0.95%；标普500指数指数跌0.43%，1月累涨1.37%。科技股普跌，AMD跌超6%，英特尔跌超 4%。黄金、白银股大幅下挫，全球最大白银ETF--iShares Silver Trust跌28%，科尔黛伦矿业跌超16%， 金田跌超14%。 ...