Financial Performance - Total revenue reached $65 million, reflecting a 63% increase adjusting for a one-time settlement agreement milestone received in Q1 2024[9] - U S net product sales grew by 41% to $34 9 million[10] - Collaboration revenue was $30 1 million[34] Prescription Trends - Q1 2025 script growth increased by 2% compared to Q4 2024[15, 16] - Early Q2 2025 prescription volume is tracking approximately 8% higher than Q1 2025[16] Market Access and Clinical Validation - The company tripled the U S field reimbursement team to 15 specialists[12] - Over 30 major healthcare plans removed prior authorizations and expanded formulary coverage for NEXLETOL and NEXLIZET[12] Global Expansion - Products are approved in 40 countries globally[21] - Approximately 472,500 patients have been reached internationally through February 2025[24] Pipeline Development - The company is developing a triple combination product with an estimated LDL-C reduction of approximately 60%-70%[19] - A program targeting Primary Sclerosing Cholangitis (PSC) is in development, with an IND planned for 2026, addressing a market opportunity estimated at over $1 billion annually[27, 30]

Core Insights - Esperion reported Q1 2025 total revenue of $65.0 million, a decrease of 53% year-over-year, but adjusted for a one-time milestone in Q1 2024, total revenue grew 63% year-over-year [1][15] - U.S. net product revenue increased by 41% year-over-year to $34.9 million [1][15] - Bempedoic acid received Level 1a recommendations in the 2025 ACC/AHA/ACEP/NAEMSP/SCAI guidelines for managing patients with Acute Coronary Syndromes [1][10] - The company expanded its development portfolio with a new program targeting Primary Sclerosing Cholangitis (PSC), a market estimated to exceed $1 billion [1][3] Financial Performance - Total revenue for Q1 2025 was $65.0 million, down from $137.7 million in Q1 2024, primarily due to a settlement agreement milestone received in the previous year [15][33] - U.S. net product revenue rose to $34.9 million from $24.8 million in the same period last year, marking a 41% increase [15][33] - Collaboration revenue fell to $30.1 million from $113.0 million year-over-year, a decrease of 73%, but grew 97% when excluding the milestone [15][33] - The company reported a net loss of $40.5 million compared to a net income of $61.0 million in Q1 2024 [13][33] Commercial Strategy - The company surpassed one million prescriptions for bempedoic acid products in the U.S. [3][6] - Esperion expanded its reimbursement team from five to 15 specialists to enhance support for healthcare providers and patients [6] - New marketing initiatives targeting statin-intolerant patients, who represent 30% of the lipid-lowering market, are expected to drive prescription growth [6][3] - The company is advancing two triple combination products for commercialization in 2027, which could provide LDL-C lowering in excess of 60% [6][3] Research and Development - Esperion hosted an R&D Day highlighting its capabilities and promising research for PSC treatment candidates [10][7] - Pre-clinical data showed that the company's allosteric ACLY inhibitor could reduce liver injury markers in PSC models [10][7] - The estimated prevalence of diagnosed PSC patients in the U.S. and Europe is approximately 76,000 as of 2024 [10][7] Market Positioning - Esperion's European partner, Daiichi Sankyo Europe, reported an 8% sequential increase in royalty revenue to $10.5 million, indicating strong market penetration for its products [10][6] - The company is on track for expected approval and pricing in Japan in the second half of 2025 [6][10]

ANN ARBOR, Mich., April 25, 2025 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today announced that the company will be participating in the webcasted Citizens Life Sciences Conference on May 8, 2025, at 12:30 p.m. ET. The live webcast can be accessed on the investor and media section of the Esperion website. Access to the webcast replay will be available approximately two hours after the completion of the call and will be archived on the Company’s website for approximately 90 days. Esperion TherapeuticsEsper ...

Welcome to R&D Day April 24, 2025 © 2025 Esperion Therapeutics, Inc. All rights reserved. Forward-looking Statements & Disclosures This investor presentation contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding marketing strategy and commercialization plans, current and planned operational expenses, future operations, commercial products, clinical development, plans for potential future product candidates, fin ...

"We are leveraging our deep expertise in ACLY biology to expand our portfolio beyond NEXLETOL (bempedoic acid)/NEXLIZET (bempedoic acid and ezetimibe) and to address the urgent needs of patients living with PSC," said Sheldon Koenig, Chief Executive Officer at Esperion. "Our lead candidates, including ESP- 1336, are promising, potential first-in-class allosteric ACLY inhibitors, well-characterized with significant preclinical data, and represent a natural extension of our metabolic franchise. PSC is a rare ...

Company Overview - Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company focused on developing new medicines for unmet patient needs, particularly in cardiovascular disease [3] - The company has developed the only FDA-approved oral, once-daily, non-statin medications for patients with elevated low-density lipoprotein cholesterol (LDL-C) [3] - Esperion's medications are supported by the CLEAR Cardiovascular Outcomes Trial, which involved nearly 14,000 patients [3] Financial Reporting - Esperion will report its first quarter 2025 financial results before the market opens on May 6, 2025 [1] - Following the financial results release, management will host a webcast at 8:00 a.m. ET to discuss the results and provide business updates [1] Business Development - The company is advancing its pre-clinical pipeline and focusing on developing ATP citrate lyase inhibitors (ACLYi) [3] - New insights into ACLYi structure and function enable rational drug design for developing potent and specific inhibitors [3] - Esperion is evolving into a leading global biopharmaceutical company through commercial execution and international partnerships [4]

Highlighting Novel Insights into ATP Citrate Lyase (ACLY) Biology and its Therapeutic Potential in Multiple Life-Threatening DiseasesANN ARBOR, Mich., April 10, 2025 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today announced that it will host an in-person R&D Day for analysts and investors on April 24, 2025, beginning at 9:00 a.m. ET in New York City. This event will feature presentations from company leadership and key opinion leaders to provide a deep dive into Esperion’s research and development strateg ...

Core Insights - Esperion has appointed Robert E. Hoffman as an independent director and Chairperson of the Audit Committee, effective immediately and May 29, 2025, respectively [1][2] - Nicole Vitullo and Antonio M. Gotto, Jr., M.D., D. Phil. will step down from the board of directors on June 1, 2025 [1] Company Developments - Robert E. Hoffman brings extensive experience in the biopharmaceutical sector, having held leadership roles in various companies, which is expected to benefit Esperion's commercialization efforts and pipeline expansion [2][4] - The company is focused on developing next-generation ATP citrate lyase inhibitors (ACLYi) to address unmet cardiometabolic needs [5][6] Leadership Background - Mr. Hoffman has previously served as President, CEO, and CFO of Kintara Therapeutics, and held senior financial roles at Heron Therapeutics and Arena Pharmaceuticals, contributing to his expertise in commercialization [2][4] - He is also involved with several other life sciences companies and has served on various financial committees, enhancing his leadership credentials [3][4] Company Overview - Esperion is a commercial-stage biopharmaceutical company that has developed the only FDA-approved oral, once-daily, non-statin medications for patients at risk for cardiovascular disease [5] - The company aims to evolve into a leading global biopharmaceutical entity through commercial execution and international partnerships [6]

ANN ARBOR, Mich., March 24, 2025 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today announced that the company will be participating in the webcasted 24th Annual Needham Virtual Healthcare Conference on April 7, 2025, at 8:45 a.m. ET. The live webcast can be accessed on the investor and media section of the Esperion website. Access to the webcast replay will be available approximately two hours after the completion of the call and will be archived on the Company’s website for approximately 90 days. Esperion ...

Esperion Therapeutics (ESPR) announced that it has come to an alignment with the FDA for initiating two phase III studies. The studies will evaluate bempedoic acid alone and in combination with ezetimibe in pediatric patients with heterozygous familial hypercholesterolemia (HeFH) and homozygous familial hypercholesterolemia (HoFH). The phase III studies are expected to begin later in 2025.Esperion markets bempedoic acid as Nexletol and Nexlizet for treating elevated LDL-C (bad cholesterol) and cardiovascula ...