Summary of Monte Rosa Therapeutics Conference Call Company Overview - **Company**: Monte Rosa Therapeutics - **Focus**: Development of molecular glue degraders for protein degradation, with applications in oncology and autoimmune diseases [3][4] Pipeline and Programs - **Molecular Glue Degrader Platform**: Utilizes small molecules that bind to ubiquitin ligase, allowing for targeted protein degradation [3][4] - **Key Programs**: - **Oncology**: - GSPT1 degrader (MRT2359) targeting castration-resistant prostate cancer (mCRPC) [5][10] - CDK2 and cyclin E1 degraders [39] - **Autoimmunity**: - VAP1 targeting strategy in collaboration with Novartis, focusing on Th17-driven autoimmune diseases [21][24] - NEXT-seven targeting NLRP3 inflammasome [32][34] Strategic Considerations - **Therapeutic Areas**: The company operates across multiple disease areas, including oncology, autoimmune diseases, cardiovascular indications, and metabolism [7][8] - **Focus on Undruggable Targets**: Emphasis on high unmet need indications where traditional therapies may not be effective [8] Clinical Development Highlights - **MRT2359**: - Selected for mCRPC due to its efficacy in preclinical models and high expression of cMYC in this cancer type [11][12] - Safety profile shows mostly grade 1 and 2 adverse events, with plans to evaluate in combination with enzalutamide [13][14] - **VAP1 Program**: - Phase I data shows 90-95% degradation levels with no safety concerns, supported by a $150 million upfront payment from Novartis [24][25] - Potential indications include inflammatory bowel disease (IBD) and rheumatoid arthritis [29][30] - **NEXT-seven**: - IND clearance expected soon, with a focus on peripheral inflammatory diseases [36][38] Future Outlook and Catalysts - **Cash Runway**: Guidance indicates a cash runway into 2028, allowing for multiple inflection points [44] - **Upcoming Updates**: - Clinical development plan for VAP1 and updates on MRT2359 in prostate cancer expected in the near term [45] - Further data on NEXT-seven anticipated following IND clearance [36][45] Key Takeaways - Monte Rosa Therapeutics is positioned to leverage its innovative molecular glue degrader platform across various therapeutic areas, with a strong focus on oncology and autoimmune diseases. - The collaboration with Novartis enhances the company's ability to explore its VAP1 program more aggressively. - The company is on track for significant clinical updates in the coming months, which could provide valuable insights into the efficacy and safety of its leading candidates.

BOSTON, May 28, 2025 (GLOBE NEWSWIRE) -- Monte Rosa Therapeutics, Inc. (Nasdaq: GLUE), a clinical- stage biotechnology company developing novel molecular glue degrader (MGD)-based medicines, today announced that Markus Warmuth, M.D., Chief Executive Officer, will participate in a fireside chat at the Jefferies Global Healthcare Conference on Wednesday, June 4, 2025, at 12:50 p.m. EDT. A webcast of the fireside chat will be accessible via the "Events & Presentations" section of Monte Rosa's website at ir.mon ...

Monte Rosa Therapeutics (GLUE) came out with quarterly earnings of $0.57 per share, beating the Zacks Consensus Estimate of a loss of $0.24 per share. This compares to loss of $0.53 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 337.50%. A quarter ago, it was expected that this biopharmaceutical company would post a loss of $0.37 per share when it actually produced earnings of $0.23, delivering a surprise of 162.16%.Over the ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from ____________ to ____________ Commission File Number: 001-40522 Monte Rosa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 84- ...

Monte Rosa Therapeutics Announces First Quarter 2025 Financial Results and Business Updates VAV1-directed MRT-6160 program advancing toward multiple Phase 2 studies, enabled by Phase 1 SAD/MAD study data supporting broad potential application in immune-mediated diseases MRT-2359 Phase 1/2 study data demonstrate encouraging signals of clinical response in heavily pretreated castration-resistant prostate cancer patients resistant to AR therapy; additional results expected in H2 2025 MRT-8102, a NEK7-directed ...

VAV1-directed MRT-6160 program advancing toward multiple Phase 2 studies, enabled by Phase 1 SAD/MAD study data supporting broad potential application in immune-mediated diseases MRT-2359 Phase 1/2 study data demonstrate encouraging signals of clinical response in heavily pretreated castration-resistant prostate cancer patients resistant to AR therapy; additional results expected in H2 2025 MRT-8102, a NEK7-directed molecular glue degrader targeting diseases driven by IL-1β and the NLRP3 inflammasome, on tr ...

Summary of findings: About CDK2 MGDs and MRT-51443 CDK2 molecular glue degrader (MGD) in combination with CDK4/6 inhibition and anti-estrogen therapy achieved superior tumor regression in vivo compared to standard of care CDK4/6 inhibition and anti-estrogen therapy Cyclin-dependent kinase 2 (CDK2) is a key driver of cell cycle progression in cancer, acting in coordination with CDK4 and CDK6 to drive cell proliferation. CDK4/6 inhibitors, in combination with endocrine therapy, are FDA-approved agents for the ...

Monte Rosa Therapeutic (GLUE) Q4 2024 Earnings Call March 20, 2025 01:22 PM ET Company Participants Andrew Funderburk - SVP, Head of Investor Relations & Strategic FinanceMarkus Warmuth - CEOFilip Janku - Chief Medical OfficerSharon Townson - Chief Scientific OfficerRobert Driscoll - SVP - Equity ResearchEllie Merle - ED - Biotech Equity ResearchEva Fortea-Verdejo - Vice President - Biotechnology Conference Call Participants Kelly Shi - SVP & Senior Research Analyst - BiotechnologyEdward Tenthoff - Sr. Rese ...

Monte Rosa Therapeutics, Inc. (NASDAQ:GLUE) Q4 2024 Results Conference Call March 20, 2025 8:00 AM ET Company Participants Andrew Funderburk - Senior Vice President, Investor Relations and Strategic Finance Markus Warmuth - Chief Executive Officer Filip Janku - Chief Medical Officer Sharon Townson - Chief Scientific Officer Phil Nickson - Chief Business and Legal Officer Conference Call Participants Kelly Shi - Jefferies Edward Tenthoff - Piper Sandler Mark Fromm - TD Cowen Robert Driscoll - Wedbush Michael ...

Monte Rosa Therapeutics (GLUE) came out with quarterly earnings of $0.23 per share, beating the Zacks Consensus Estimate of a loss of $0.37 per share. This compares to loss of $0.58 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 162.16%. A quarter ago, it was expected that this biopharmaceutical company would post a loss of $0.45 per share when it actually produced a loss of $0.29, delivering a surprise of 35.56%.Over the las ...