Core Viewpoint - Harmony Biosciences Holdings, Inc. (HRMY) is currently viewed as a more attractive investment compared to argenex SE (ARGX) due to its stronger earnings outlook and better valuation metrics [1][3][7] Valuation Metrics - HRMY has a forward P/E ratio of 9.48, significantly lower than ARGX's forward P/E of 29.52, indicating that HRMY may be undervalued [5] - The PEG ratio for HRMY is 0.35, while ARGX has a PEG ratio of 0.72, suggesting that HRMY offers better value relative to its expected earnings growth [5] - HRMY's P/B ratio stands at 2.61, compared to ARGX's P/B of 8.36, further highlighting HRMY's superior valuation [6] Investment Ratings - HRMY holds a Zacks Rank of 1 (Strong Buy), while ARGX has a Zacks Rank of 3 (Hold), indicating a more favorable investment outlook for HRMY [3][7] - Based on the valuation metrics and earnings outlook, HRMY is considered the superior value option at this time [7]

Core Viewpoint - Harmony Biosciences Holdings, Inc. will report its fourth quarter and full year 2025 financial results on February 24, 2026, before the U.S. financial markets open [1] Financial Reporting - The financial results will be discussed in a conference call and webcast scheduled for February 24, 2026, at 8:30 a.m. ET [1] - Participants can join the call by dialing 800-274-7083 for domestic calls or 203-518-9786 for international calls, using the passcode HRMYQ425 [1]

Core Viewpoint - Harmony Biosciences Holdings, Inc. (HRMY) is highlighted as a reasonably valued biopharma firm, with a focus on its stock performance since the last analysis in June of the previous year [1]. Group 1: Company Overview - Harmony Biosciences is positioned within the biotech sector, which is characterized by high beta and potential for significant investor returns [1]. - The company is part of a model portfolio that includes 12-20 high upside biotech stocks, indicating a strategic selection aimed at maximizing investment opportunities [1]. Group 2: Analyst Background - The analyst, Bret Jensen, has over 13 years of experience as a market analyst, specializing in identifying high-potential investments in the biotech sector [1]. - The Biotech Forum, led by the analyst, offers live discussions on trade ideas, market commentary, and weekly updates on portfolio performance [1].

Company Overview - Harmony Biosciences is a U.S.-based biopharmaceutical company focused on therapies for rare neurological diseases, with WAKIX being a notable product for narcolepsy [5] - The company reported a total revenue of $825.94 million and a net income of $185.68 million for the trailing twelve months (TTM) [4] - The company has 268 employees and experienced a 1-year price change of -5.92% as of January 31, 2026 [4] Recent Executive Transactions - Sandip Kapadia, the Chief Financial Officer, sold 3,746 shares on January 26, 2026, for approximately $139,171 [1][2] - Following this transaction, Kapadia's direct holdings decreased to 24,521 shares from over 127,000 shares in March 2023 [8] - The transaction value was based on a weighted average purchase price of $37.15, with a post-transaction value of $916,105 based on the market close of $37.36 [2] Financial Performance and Outlook - Harmony Biosciences expects to achieve over $1 billion in revenue from WAKIX by the end of 2026, supported by an exclusive license for the medication [9] - The company has other medications in advanced development stages, projected to sustain operations into 2040 [10] - A 10% revenue increase is anticipated for 2025, indicating strong financial results and a positive outlook for investors [10] Investor Implications - Despite the recent sale by Kapadia, Harmony Biosciences' financials remain strong, particularly highlighted by a robust Q3 2025 net income, the highest since Q3 2022 [7] - The recent sale size of 3,746 shares is significantly below Kapadia's median sale size of 13,494 shares, suggesting a potential for further material sales [8]

Core Insights - Harmony Biosciences has shown promising financial performance, but the CFO, Sandip Kapadia, sold all her direct equity ownership in January 2026, raising questions about insider sentiment [1][6]. Financial Overview - As of January 31, 2026, Harmony Biosciences' stock price was $35.52, with a market capitalization of $2.1 billion, revenue of $825.94 million, and net income of $185.68 million [4]. - The transaction involved the sale of 20,961 shares for approximately $752,800, executed at a weighted average price of $35.92 per share [2][9]. Company Profile - Harmony Biosciences is a U.S.-based biopharmaceutical company focused on therapies for rare neurological diseases, with WAKIX being a notable product for treating narcolepsy [5]. Future Outlook - The company anticipates over $1 billion in revenue from WAKIX by the end of 2026, supported by an exclusive license for the medication [7]. - Other medications in advanced development stages are projected to sustain revenue generation into 2040, with a 10% increase in 2025 [8]. Insider Trading Context - Kapadia's sale fully liquidated her direct holdings, which had previously been reduced from 72,948 shares to zero over the past year [9]. - The sale price was slightly below the market close of $36.41 on the transaction date and below the current share price of $36.62 as of January 31, 2026 [9].

Market Overview - The U.S. stock market showed subdued performance, with the Dow Jones Industrial Average increasing by 0.11% to 49,071.56, while the S&P 500 decreased by 0.13% to 6,969.01, and the Nasdaq Composite fell by 0.72% to 23,685.12 [1] - The technology sector experienced a significant sell-off, particularly in Microsoft Corporation (MSFT) shares, due to concerns over slower cloud growth, although Meta provided some offsetting strength [2] Value Stocks Analysis - Value stocks are highlighted as appealing investment opportunities amid cautious market sentiment, driven by rising oil prices and geopolitical tensions [2] - The Price to Cash Flow (P/CF) ratio is emphasized as an effective valuation metric, indicating that a lower P/CF ratio suggests better value and strong cash generation potential [3][4] - Analysts note that cash flow is a more reliable indicator of a company's financial health compared to earnings, which can be influenced by accounting estimates and management manipulation [5] Investment Strategy - A comprehensive investment strategy should include multiple valuation metrics such as price-to-book ratio, price-to-earnings ratio, and price-to-sales ratio, alongside a favorable Zacks Rank and Value Score [7] - Parameters for selecting true-value stocks include a P/CF ratio less than or equal to the industry median, a minimum stock price of $5, and an average 20-day trading volume greater than 100,000 [8] Selected Value Stocks - Four companies—Harmony Biosciences Holdings, Inc. (HRMY), Universal Health Services, Inc. (UHS), Concentrix Corporation (CNXC), and Global Payments Inc. (GPN)—meet strict value criteria, showing low P/CF ratios and solid financial health [9] - Each of these companies is projected to grow both sales and earnings per share (EPS) in the current financial year, with all carrying a Value Score of A and demonstrating consistent positive earnings surprises [9] Company-Specific Insights - Harmony Biosciences is projected to see sales growth of 21.4% and EPS growth of 25.9% for the current financial year, despite a 4.9% decline in share price over the past year [13] - Universal Health Services anticipates sales growth of 9.7% and EPS growth of 31.3%, with shares rising by 6.1% in the past year [14] - Concentrix Corporation expects sales growth of 2.9% and EPS growth of 4.8%, although its shares have dropped by 26.1% in the past year [15] - Global Payments forecasts sales growth of 1.8% and EPS growth of 5.8%, with shares declining by 36.8% over the past year [16]

Core Viewpoint - Investors are increasingly seeking growth stocks that demonstrate above-average growth potential, with Harmony Biosciences Holdings, Inc. (HRMY) identified as a strong candidate due to its favorable growth metrics and Zacks Rank [2][10]. Group 1: Earnings Growth - Harmony Biosciences has a historical EPS growth rate of 13.1%, but projected EPS growth for this year is significantly higher at 26.7%, surpassing the industry average of 13% [4]. - Double-digit earnings growth is a key indicator for growth investors, suggesting strong future prospects and potential stock price increases [3]. Group 2: Cash Flow Growth - The company currently exhibits a year-over-year cash flow growth of 10%, which is notably higher than the industry average of -4.5% [5]. - Over the past 3-5 years, Harmony Biosciences has achieved an annualized cash flow growth rate of 25.7%, compared to the industry average of 4.1% [6]. Group 3: Earnings Estimate Revisions - Recent upward revisions in current-year earnings estimates for Harmony Biosciences indicate a positive trend, with the Zacks Consensus Estimate increasing by 7.5% over the past month [8]. - The correlation between earnings estimate revisions and stock price movements supports the potential for near-term price appreciation [7]. Group 4: Overall Assessment - Harmony Biosciences has achieved a Zacks Rank of 1 (Strong Buy) and a Growth Score of B, indicating its potential as an outperformer and a solid choice for growth investors [10].

Group 1 - The current market environment makes it challenging to find value stocks, particularly in the biotech sector, where Harmony Biosciences specializes in treatments for rare diseases [1] - Harmony's pitolisant treatment, marketed as Wakix, has been financially lucrative, with significant revenue growth since its FDA approval in 2019 [2][4] - Harmony's revenue reached $160 million in the year following FDA approval, with a compound annual growth rate of around 40%, projecting nearly $870 million in sales for 2025 and over $1 billion in 2026 [4] Group 2 - Unlike many biotech firms that increase spending on pipeline research post-approval, Harmony became profitable in 2021, with net income rising over five times to $186 million in the past 12 months [5] - Despite strong financial performance, Harmony's stock price has remained flat since its IPO, partly due to concerns over the expiration of Wakix's patent in early 2030 and potential generic competition [6] - Controversies and litigation surrounding Wakix, along with long-term worries about patent cliffs and Harmony's pipeline, have negatively impacted investor sentiment [7]

Core Insights - Investors in the Medical - Biomedical and Genetics sector should consider Harmony Biosciences Holdings, Inc. (HRMY) and argenex SE (ARGX) for potential value opportunities [1] Valuation Metrics - HRMY has a forward P/E ratio of 9.20, significantly lower than ARGX's forward P/E of 29.47 [5] - HRMY's PEG ratio is 0.34, while ARGX's PEG ratio is 0.54, indicating HRMY may offer better value relative to its expected earnings growth [5] - HRMY has a P/B ratio of 2.54 compared to ARGX's P/B of 8.18, further suggesting HRMY is undervalued [6] Zacks Rank and Earnings Outlook - HRMY holds a Zacks Rank of 1 (Strong Buy), indicating positive earnings estimate revisions, while ARGX has a Zacks Rank of 5 (Strong Sell) [3] - The stronger estimate revision activity for HRMY suggests a more favorable earnings outlook compared to ARGX [7] Value Grades - HRMY has a Value grade of A, while ARGX has a Value grade of D, reflecting HRMY's more attractive valuation metrics [6]

Group 1 - The market environment has favored growth stocks over the past 15 years, leading to high valuations that traditional value investors find challenging [1] - Despite skepticism from analysts regarding the overvaluation of growth stocks, their prices have continued to rise due to strong business performance [1] - Aggressive value investors who shorted these growth stocks have faced significant losses [1] Group 2 - Harmony Biosciences (NASDAQ: HRMY) is a lesser-known biotech company that presents an attractive opportunity for traditional value investors [2] - The company has experienced business success that is not fully reflected in its stock price, warranting further investigation [2] - Harmony focuses on rare neurological disorders, an area with unmet treatment needs and less competition compared to more common diseases [6][5] Group 3 - The biotechnology sector often features stocks with high valuations based on future prospects, making attractively priced options like Harmony worth examining [7]