PHILADELPHIA, Feb. 25, 2026 (GLOBE NEWSWIRE) -- Century Therapeutics, Inc. (‘Century’, NASDAQ: IPSC), a biotechnology company developing induced pluripotent stem cell (iPSC)-derived cell therapies for autoimmune diseases, including type 1 diabetes, and cancer, today announced that the company will participate in the following upcoming investor conferences in March: TD Cowen 46th Annual Health Care Conference: Fireside chat at 9:50 a.m. ET on Wednesday, March 4, 2026, in Boston, MA. Leerink Partners Global H ...

Core Insights - The report highlights the growing momentum in the clinical trial pipeline for iPSC-derived NK cells, with over 12 companies actively developing more than 15 pipeline drugs [1][5] - It provides a comprehensive analysis of the competitive landscape, emerging therapies, and clinical strategies, enabling stakeholders to make informed decisions [1][5] Company and Drug Pipeline Overview - Key companies involved in the development of iPSC-derived NK cells include Centuary Therapeutics, Fate Therapeutics, and Cartherics Pty Ltd, among others [5][6] - Prominent drugs in the pipeline include CNTY-101, FT522, NCR300, and CTH-401, which are at various stages of clinical trials [5][6] Clinical Development and Regulatory Insights - The report includes insights into clinical trial benchmarking, partnering and licensing activities, and regulatory pathways involving the FDA and EMA [1] - Recent developments include Century Therapeutics continuing the CNTY-101 trial and ViGenCell's agreement with Therabest for TB-420, an iPSC-derived NK cell therapy [9] Advantages of iPSC-derived NK Cells - iPSC-derived NK cells offer significant advantages over traditional donor-derived NK cells, including a renewable source, consistent phenotype, and the ability to be genetically engineered for enhanced efficacy [4][5] - Their potential to overcome limitations of primary NK cells positions them as a cornerstone of next-generation immunotherapy [5][6] Market Dynamics and Future Perspectives - The report indicates strong market momentum driven by the unique properties of iPSC-derived NK cells, including clonal uniformity and off-the-shelf manufacturability [5][6] - With advancing clinical validation and regulatory frameworks, iPSC-derived NK cells are expected to become a foundational modality in cancer immunotherapy [5][6]

Core Insights - The article discusses the investment strategy focused on clinical-stage biotech stocks, emphasizing a long-only approach that includes both long-term ideas and event-driven trading [1] Group 1: Investment Strategy - The investment style is centered on clinical-stage biotech stocks, leveraging an academic and medical background to assess scientific fundamentals [1] - The analyst expresses a beneficial long position in IPSC shares, indicating confidence in the stock's potential [1] Group 2: Limitations and Disclosures - Due to time constraints and Seeking Alpha rules, not all stocks being followed or traded can be covered in the article [1] - The article is written independently, with no compensation received from companies mentioned, ensuring unbiased opinions [1]

Group 1 - Century Therapeutics Inc. (NASDAQ:IPSC) is recognized as a fast-growing penny stock, with analysts highlighting its potential for investment [1] - Piper Sandler raised its price target for Century Therapeutics to $4 from $2, citing the company's plan to submit an IND for CNTY-813 this year and deliver initial data by 2027 [1] - The company has a strong financial position, with an estimated pro forma cash balance of approximately $267 million, expected to fund operations through Q1 2029 [1] Group 2 - Clear Street analyst Bill Maughan reduced the price target for Century Therapeutics to $6.60 from $8 while maintaining a Buy rating, noting that a recent private placement extends the company's cash runway into Q1 2029 [2] - The reduction in price target by Clear Street accounts for dilution from the capital raise but is offset by an increased likelihood of pipeline success and higher projected peak sales [3] - Century Therapeutics is a clinical-stage biotechnology company focused on developing allogeneic cell therapies for solid tumors, hematological malignancies, and autoimmune diseases [4]

Core Insights - Premarket trading is showing notable activity with significant price movements indicating potential trading opportunities before the market opens [1] Premarket Gainers - TechCreate Group Ltd. (TCGL) is up 99% at $205.71 - VivoSim Labs, Inc. (VIVS) is up 74% at $2.96 - La Rosa Holdings Corp. (LRHC) is up 55% at $4.66 - Sandisk Corporation (SNDK) is up 23% at $668.13 - Springview Holdings Ltd (SPHL) is up 19% at $4.76 - BUUU Group Limited (BUUU) is up 16% at $10.86 - Deckers Outdoor Corporation (DECK) is up 11% at $111.64 - Lumentum Holdings Inc. (LITE) is up 10% at $419.58 - Chanson International Holding (CHSN) is up 10% at $2.15 - Century Therapeutics, Inc. (IPSC) is up 9% at $2.20 [3] Premarket Losers - Kaixin Holdings (KXIN) is down 43% at $5.70 - Brand Engagement Network, Inc. (BNAI) is down 32% at $35.56 - PennyMac Financial Services, Inc. (PFSI) is down 21% at $117.50 - Schneider National, Inc. (SNDR) is down 19% at $24.05 - Moolec Science SA (MLEC) is down 19% at $5.23 - Nuwellis, Inc. (NUWE) is down 18% at $3.43 - Digital Currency X Technology Inc. (DCX) is down 16% at $3.44 - Serina Therapeutics, Inc. (SER) is down 15% at $3.03 - Namib Minerals (NAMM) is down 11% at $5.00 - ZeroStack Corp. (ZSTK) is down 6% at $11.00 [4]

Core Viewpoint - Century Therapeutics, Inc. has been upgraded to a Zacks Rank 1 (Strong Buy) due to an upward trend in earnings estimates, which is a significant factor influencing stock prices [1][4]. Earnings Estimates - The Zacks Consensus Estimate for Century Therapeutics indicates an expected earnings of -$0.14 per share for the fiscal year ending December 2025, showing no year-over-year change [9]. - Over the past three months, the Zacks Consensus Estimate for the company has increased by 31.9%, reflecting a positive outlook on earnings [9]. Zacks Rating System - The Zacks rating system is based solely on a company's changing earnings picture, which is tracked through the consensus of EPS estimates from sell-side analysts [2]. - The system classifies stocks into five groups, with Zacks Rank 1 stocks historically generating an average annual return of +25% since 1988 [8]. - Only the top 5% of Zacks-covered stocks receive a "Strong Buy" rating, indicating superior earnings estimate revisions [10][11]. Market Implications - Rising earnings estimates and the subsequent rating upgrade for Century Therapeutics suggest an improvement in the company's underlying business, likely leading to increased stock prices [6]. - The correlation between earnings estimate revisions and near-term stock movements highlights the importance of tracking these revisions for investment decisions [7].

Core Viewpoint - Century Therapeutics has announced a private placement to raise approximately $135 million to support the development of its lead product candidate, CNTY-813, aimed at treating Type 1 diabetes [1][2][3]. Financing Details - The financing is led by new investor TCGX, with participation from various investors including RA Capital Management and Venrock Healthcare Capital Partners [2]. - The private placement is expected to close on January 9, 2026, pending customary closing conditions [2]. - Century will issue approximately 117,391,299 shares of common stock at a price of $1.15 per share, along with warrants to purchase an additional 58,695,648 shares [3][4]. Use of Proceeds - The net proceeds from the private placement will be utilized to fund the development of CNTY-813, as well as for working capital and other general corporate purposes [5]. Product Development Timeline - The financing is projected to extend the company's cash runway to Q1 2029, with an anticipated IND submission for CNTY-813 in 2026 and initial clinical data expected in 2027 [3]. Securities Offering - The securities are offered in a private placement under Section 4(a)(2) of the Securities Act of 1933 and have not been registered under the Securities Act [6]. - Century has agreed to file a registration statement with the SEC to register the resale of the shares issued in the private placement [6]. Company Overview - Century Therapeutics is focused on developing induced pluripotent stem cell (iPSC)-derived cell therapies for autoimmune diseases and cancer [9][10]. - The company leverages its novel immune evasion engineering technology, Allo-Evasion™, to create off-the-shelf cell therapies [10].

Core Viewpoint - Momentum investing focuses on "buying high and selling higher," contrasting with traditional strategies of "buying low and selling high" [1] Group 1: Momentum Investing Strategy - Investors following momentum investing tend to avoid undervalued stocks, believing that quicker profits can be made from trending stocks [1] - Identifying the right entry point for fast-moving stocks can be challenging, as these stocks may lose momentum if their growth potential does not justify their high valuations [1] Group 2: Investment Opportunities - The Zacks Momentum Style Score is useful for identifying strong momentum stocks, while the 'Fast-Paced Momentum at a Bargain' screen helps find attractively priced stocks with momentum [2] - Century Therapeutics, Inc. (IPSC) is highlighted as a strong candidate, having experienced a 3.9% price increase over the past four weeks [3] Group 3: Performance Metrics - IPSC has shown a 14.6% price gain over the past 12 weeks, indicating strong momentum, with a beta of 1.8, suggesting it moves 80% more than the market [4] - IPSC has a Momentum Score of B, indicating a favorable time to invest based on its momentum [5] Group 4: Earnings and Valuation - An upward trend in earnings estimate revisions has contributed to IPSC's Zacks Rank 2 (Buy), which is associated with strong momentum effects [6] - IPSC is trading at a Price-to-Sales ratio of 0.43, suggesting it is undervalued, as investors pay only 43 cents for each dollar of sales [6] Group 5: Additional Investment Options - Besides IPSC, there are other stocks that meet the criteria of the 'Fast-Paced Momentum at a Bargain' screen, presenting further investment opportunities [7] - Zacks offers over 45 Premium Screens tailored to different investing styles, aiding in stock selection [8]

Core Insights - Century Therapeutics has appointed Dr. Han Lee and Dr. Martin Murphy to its Board of Directors, enhancing its leadership team at a critical time for the company [1][2] Company Overview - Century Therapeutics is a biotechnology company focused on developing induced pluripotent stem cell (iPSC)-derived cell therapies aimed at treating autoimmune diseases and cancer [4] - The company utilizes its iPSC cell foundry and a novel immune evasion engineering technology called Allo-Evasion™ to create off-the-shelf cell therapies, which are expected to improve patient access and offer advantages over existing therapies [4] Leadership Appointments - Dr. Han Lee will serve on the Audit and Compensation Committees, bringing extensive experience in capital formation and corporate development from his previous roles at ImmPACT Bio, Neogene Therapeutics, and AstraZeneca [1][2] - Dr. Martin Murphy will be part of the Compensation and Nominating and Corporate Governance Committees, with a strong background in life science investment and company creation from his roles at Syncona and MVM Life Science Partners [1][3] Strategic Focus - The company is prioritizing the advancement of its iPSC-derived cell therapy programs, particularly CNTY-813, which is being developed as a potentially curative treatment for type 1 diabetes [2]

Summary of Century Therapeutics FY Conference Call Company Overview - **Company**: Century Therapeutics (NasdaqGS: IPSC) - **Focus**: Development of induced pluripotent stem cells (iPSCs) for CAR T cells and natural killer (NK) cells targeting autoimmune diseases and cancer [1][2] Key Developments - **CNTY813**: New program for iPSC-derived beta islet cells aimed at treating type 1 diabetes [1] - **CNTY308**: A CD19 CAR-iT cell therapy that is being developed for autoimmune diseases [1][19] Core Advantages of iPSC-Derived Therapies 1. **Engineerability**: Ability to harness synthetic biology for cell therapy [4] 2. **Characterization and Reproducibility**: High control over the differentiation process of iPSCs [4] 3. **Profitable Scalability**: Pathway to achieve antibody-like scale and cost efficiency [5] Alloevasion Technology - **Definition**: A set of genetic edits that allow iPSC-derived cells to coexist with the patient's immune system [6] - **Key Features**: - Removal of HLAs to prevent T cell engagement [7] - Introduction of a universal NK cell inhibitory ligand for protection against NK cells [8] - IgG degrading protease to mitigate antibody-mediated immunity [9][10] Clinical Development Plans - **CNTY813**: On track for IND-enabling stages by the end of 2025, with tumorigenicity studies underway [18] - **CNTY308**: Clinical trials planned to initiate next year, focusing primarily on autoimmune diseases [23][24] Market Opportunity - **Type 1 Diabetes**: Approximately 2 million patients in the U.S. and 9 million worldwide, presenting a significant unmet medical need [32] - **Autoimmune Diseases**: Over 50 million patients in the U.S., indicating a large potential market for CNTY308 [22] Partnerships and Future Plans - Continuous dialogue with pharmaceutical companies for potential partnerships, especially in Type 1 diabetes and autoimmune disease markets [31][32] - Exploration of regenerative medicine opportunities, including potential applications in Parkinson's disease and cardiac disease [36][38] Financial Position - **Cash Reserves**: Approximately $133 million, expected to fund operations into Q4 2027 [39] - **Upcoming Catalysts**: Clinical data generation for CNTY101 and CNTY308, and IND submission for type 1 diabetes expected in 2026 [39] Conclusion Century Therapeutics is positioned at the forefront of iPSC-derived cell therapies, with innovative approaches to address significant medical needs in autoimmune diseases and type 1 diabetes. The company's focus on Alloevasion technology and scalable manufacturing processes enhances its potential for success in the competitive biotech landscape.