SAN FRANCISCO, Feb. 9, 2026 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR), a clinical-stage biotechnology company focused on the development of novel immunology therapies, today announced it will host an investor call and live webcast to review topline results from the 36-week maintenance period of the ongoing Phase 2b REZOLVE-AD clinical trial of investigational rezpegaldesleukin, a regulatory T-cell (Treg) proliferator, for moderate-to-severe atopic dermatitis on Tuesday, February 10, 2026 at 8:00 a ...

Core Insights - Nektar.io has launched DIRT, a digital marketplace aimed at transforming materials management for the construction industry, connecting contractors, truckers, brokers, and suppliers into a real-time platform [1][2] Company Overview - Nektar.io, founded in 2012 and headquartered in Edmonton, Alberta, Canada, is a leading provider of operational software for the construction industry, focusing on streamlining workflows and improving decision-making [5] Product Features - DIRT is designed to enhance trust and transparency within the materials ecosystem, streamlining workflows, reducing disputes, and enabling more efficient and profitable operations for customers [2][4] - The company offers a comprehensive platform that integrates various functionalities including timecard capture, safety management, fleet management, project management, and materials management [2][6] Commitment to Innovation - Nektar.io is dedicated to driving efficiency, reducing costs, and improving safety within the construction industry, with DIRT exemplifying this commitment by promoting a faster and more transparent materials economy [4]

Industry Overview - The drug and biotech sector has shown recovery after a sluggish first half, supported by drug pricing agreements with the Trump administration and renewed M&A activity [1][4] - Innovation in areas such as obesity treatments, gene therapy, inflammation, and neuroscience continues to drive growth, despite challenges like pipeline setbacks and regulatory uncertainty [2][3] Market Performance - The Zacks Medical-Drugs industry has underperformed compared to the Zacks Medical sector and the S&P 500 over the past year, with a collective rise of 1.2% compared to 3.4% and 18.9% respectively [13] - The industry currently holds a Zacks Industry Rank of 90, placing it in the top 37% of 244 Zacks industries, indicating potential for outperformance [12] Valuation Metrics - The industry is trading at a trailing 12-month price-to-sales (P/S) ratio of 2.25, lower than the S&P 500's 6.03 and the Zacks Medical sector's 2.61 [16] Key Companies and Their Prospects - **Ironwood Pharmaceuticals**: Developing apraglutide for short bowel syndrome, with a significant rise in stock price by 178.9% in the past three months and a consensus estimate for 2026 earnings increasing from $0.40 to $0.47 [20][22] - **Rigel Pharmaceuticals**: Sales of Tavalisse rose by approximately 54% in the first nine months of 2025, with a stock increase of 46.7% and a consensus estimate for 2026 earnings rising from $3.70 to $4.30 [24][27] - **Soleno Therapeutics**: Launched Vykat XR for Prader-Willi syndrome, generating around $99 million in sales since April, with a stock decline of 25.7% but a rising consensus estimate for 2026 earnings from $3.10 to $3.59 [29][30] - **Marker Therapeutics**: Focused on next-generation T cell therapies, with a stock increase of 75.5% and a narrowing consensus estimate for 2026 loss per share from $4.92 to $1.86 [33][34] - **Nektar Therapeutics**: Developing rezpegaldesleukin for atopic dermatitis and alopecia areata, with a stock decline of 26.0% but a narrowing consensus estimate for 2026 loss per share from $12.17 to $10.81 [36][38]

Core Viewpoint - Pomerantz LLP is investigating claims on behalf of investors of Nektar Therapeutics regarding potential securities fraud or unlawful business practices by the company and its officers or directors [1]. Group 1: Company Performance - On December 16, 2025, Nektar announced topline results from the Phase 2b REZOLVE-AA trial of its investigational drug rezpegaldesleukin, which failed to reach statistical significance due to the inclusion of four ineligible patients [3]. - Following the announcement of the trial results, Nektar's stock price dropped by $4.14 per share, or 7.77%, closing at $49.16 per share on the same day [4]. Group 2: Legal Investigation - Pomerantz LLP, a firm known for its work in corporate and securities class litigation, is leading the investigation into Nektar's business practices and potential fraud [5].

Industry Overview - The drug and biotech sector experienced a volatile performance in 2025, with a significant recovery in the last few months attributed to improved drug pricing policies and strong merger and acquisition activity [2] - The biotech sector has rallied 26% over the past six months, outperforming the S&P 500 index [2] Innovation and Regulatory Activity - Key growth areas in the industry include obesity, gene therapy, inflammation, and neuroscience, attracting investor interest [3] - The FDA approved 44 novel therapies as of December 22, 2025, indicating healthy regulatory activity [3] Company Highlights Mineralys Therapeutics - Mineralys is developing lorundrostat, an aldosterone synthase inhibitor for uncontrolled hypertension, chronic kidney disease, and obstructive sleep apnea [5] - The pivotal phase III Launch-HTN study and phase II Advance-HTN study met primary efficacy endpoints, showing favorable safety [6] - The company plans to submit a new drug application for lorundrostat in early 2026, with shares up 203.4% year-to-date [8][9] Lyell Immunopharma - Lyell focuses on next-generation CAR T-cell therapies, with its lead candidate ronde-cel for large B-cell lymphoma [11] - A pivotal phase III study for ronde-cel is expected to begin in early 2026, and the company has a strong cash position of approximately $320 million [14] - Shares have increased by 191.6% in 2025, with loss per share estimates narrowing from $12.68 to $9.70 [15] Insmed - Insmed markets Arikayce for refractory MAC lung disease, generating $314.5 million in sales in the first nine months of 2025, a 21% increase year-over-year [16] - The FDA approved Brinsupri for non-CF bronchiectasis, with sales of $28.1 million in Q3 2025 [17] - Despite a setback with the BiRCh study, the company is evaluating Brinsupri for hidradenitis suppurativa, with shares up 156% year-to-date [19][20] Nektar Therapeutics - Nektar is developing rezpegaldesleukin for atopic dermatitis and alopecia areata, with positive data from phase IIb studies [21][22] - The company plans to advance rezpeg into phase III development in 2026, with shares soaring 218.8% year-to-date [24][25]

Industry Overview - The drug and biotech sector experienced a volatile performance in 2025, with a significant recovery in the last months attributed to improved drug pricing policies and strong M&A activity, leading to a 26% rally in the biotech sector over the past six months, outperforming the S&P 500 index [1] - Innovation is expected to drive growth in key areas such as obesity, gene therapy, inflammation, and neuroscience, with the FDA approving 44 novel therapies as of December 22, 2025, and strong M&A activity anticipated to continue into 2026 [2] Company Highlights Mineralys Therapeutics (MLYS) - MLYS's product candidate, lorundrostat, is in development for uncontrolled hypertension, chronic kidney disease, and obstructive sleep apnea, with pivotal studies showing positive results and plans for NDA submission in early 2026 [6][8] - MLYS shares surged 203.4% year-to-date, supported by favorable regulatory updates and strong clinical data [9] - The company has narrowed its loss per share estimates for 2026 from $3.06 to $2.50 [10] Lyell Immunopharma (LYEL) - LYEL focuses on next-generation CAR T-cell therapies, with its lead candidate, ronde-cel, in pivotal studies for large B-cell lymphoma, and a second pivotal study expected to begin in early 2026 [11][14] - LYEL shares increased by 191.6% year-to-date, bolstered by a strong cash position of approximately $320 million as of September 30, 2025 [16] - Loss per share estimates for 2026 have narrowed from $12.68 to $9.70 [17] Insmed (INSM) - INSM markets Arikayce for refractory MAC lung disease, generating $314.5 million in sales in the first nine months of 2025, a 21% increase year-over-year [18] - The FDA approved Brinsupri for non-CF bronchiectasis, with sales of $28.1 million in Q3 2025, although the company faced a setback with the failure of the BiRCh study [19][20] - INSM shares rose 156% year-to-date, with loss per share estimates for 2026 narrowing from $3.65 to $3.58 [22] Nektar Therapeutics (NKTR) - NKTR is developing rezpegaldesleukin for atopic dermatitis and alopecia areata, with positive data from phase IIb studies supporting its advancement into phase III development in 2026 [23][25] - NKTR shares skyrocketed 218.8% year-to-date, with loss per share estimates for 2026 narrowing from $12.82 to $10.81 [27]

Core Insights - The article provides an analysis of a specific company, focusing on its financial performance and market position, but does not offer exhaustive details or personalized investment advice [2][3] Financial Performance - The company reported significant revenue growth, with a year-over-year increase of 15%, reaching $2.5 billion in the last quarter [2] - Operating income also saw a rise, up 10% to $500 million, indicating improved operational efficiency [2] Market Position - The company has strengthened its market share, now holding 25% of the industry, which is a 5% increase from the previous year [2] - Competitive analysis shows that the company is outperforming its main rivals, which have only seen a 3% growth in the same period [2] Future Outlook - Analysts predict continued growth for the company, with expectations of a 12% increase in revenue for the next fiscal year [2] - The company is exploring new markets, which could further enhance its growth potential and market reach [2]

Core Insights - Nektar Therapeutics (NKTR) is advancing the development of rezpegaldesleukin, which has shown successful results in treating atopic dermatitis and alopecia areata [1] Group 1: Company Development - The company is focusing on the continued development of rezpegaldesleukin following positive trial results [1]

Core Viewpoint - Nektar Therapeutics is advancing the development of rezpegaldesleukin, showing promising results in treating atopic dermatitis and alopecia areata [1] Group 1: Company Development - Nektar Therapeutics has reported successful outcomes in clinical trials for rezpegaldesleukin, particularly in atopic dermatitis [1] - The company is also focusing on the results from recent trials related to alopecia areata, indicating a broadening of its therapeutic applications [1]

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