Financial Data and Key Metrics Changes - The company finished the first quarter with just under $30 million in cash, with a projected cash runway extending into the first quarter of 2027, indicating a strong financial position for a small company in the current market [51]. Business Line Data and Key Metrics Changes - NXP-800 is currently in a Phase Ib program targeting aggressive subsets of ovarian cancer, with early data showing a partial response and stable disease in initial patients, although there were concerns regarding thrombocytopenia [15][17]. - NXP-900 is in a Phase 1a dose escalation, with early indications of safety and significant SRC inhibition, suggesting it may be a best-in-class SRC inhibitor [35][39]. Market Data and Key Metrics Changes - The addressable patient populations for NXP-800 and NXP-900 vary significantly, with potential expansions into larger indications like endometrial cancer if positive signals are observed in ongoing studies [22]. Company Strategy and Development Direction - The company is focused on precision medicine in oncology, aiming to address severe unmet medical needs with targeted therapies [4]. - There is a strategic emphasis on developing NXP-900 as a transformational drug with potential applications across multiple tumor types, leveraging its selective inhibition of SRC kinases [24][28]. Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the upcoming data updates for both NXP-800 and NXP-900, indicating that the next few months could be eventful and potentially transformational for the company [51][53]. - The management team highlighted their extensive experience in successfully bringing drugs to market, which they believe positions the company well for future success [6]. Other Important Information - The insider ownership is significant, with co-founders and major shareholders collectively owning about 50-55% of the company, reflecting strong alignment with shareholder interests [51]. - The company has seen consistent insider buying since going public, indicating confidence in the company's future prospects [51]. Q&A Session Summary Question: What is the current status of NXP-800 and NXP-900? - NXP-800 is in a Phase Ib program with encouraging early results, while NXP-900 is completing Phase 1a and preparing to enter Phase 1b soon [51][53].

Fort Lee, NJ, May 16, 2025 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced that Ron Bentsur, Chairman and Chief Executive Officer, will present at the 3rd Annual H.C. Wainwright Global BioConnect Investor Conference. Event3rd Annual H.C. Wainwright BioConnect Investor Conferen ...

Nuvectis Pharma, Inc. (NVCT) closed the last trading session at $9.22, gaining 8.2% over the past four weeks, but there could be plenty of upside left in the stock if short-term price targets set by Wall Street analysts are any guide. The mean price target of $19.25 indicates a 108.8% upside potential.The mean estimate comprises four short-term price targets with a standard deviation of $4.35. While the lowest estimate of $15 indicates a 62.7% increase from the current price level, the most optimistic analy ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to . Commission File Number 001-41264 NUVECTIS PHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 86-2405608 (State or Other ...

Financial Performance - The net loss for the first quarter of 2025 was $5.3 million, compared to a net loss of $4.2 million for the same period in 2024, representing an increase of $1.1 million [4]. - The basic and diluted net loss per common share outstanding was $0.27 for the first quarter of 2025, compared to $0.25 for the same period in 2024 [15]. Cash and Assets - Cash and cash equivalents increased to $29.9 million as of March 31, 2025, from $18.5 million as of December 31, 2024, reflecting a $11.4 million increase due to a public offering [3]. - The total assets as of March 31, 2025, were $30.1 million, compared to $18.6 million as of December 31, 2024 [13]. - The total liabilities as of March 31, 2025, were $9.2 million, unchanged from December 31, 2024 [13]. - The company completed a financing round of $15.5 million, extending its cash runway into the first quarter of 2027 [5]. Expenses - Research and development expenses rose to $3.7 million for the first quarter of 2025, up from $2.7 million in the same quarter of 2024, an increase of approximately 37% [6]. - General and administrative expenses were $1.9 million for the first quarter of 2025, compared to $1.7 million for the same period in 2024, an increase of about 11.8% [6]. Clinical Development - NXP900 demonstrated a robust pharmacodynamic response and acceptable safety profile in the Phase 1a dose escalation study, with plans to enter Phase 1b for specific genetic alterations [2]. - The company is advancing two clinical-stage drug candidates, NXP800 and NXP900, targeting serious conditions in oncology [8].

Phase 1a dose-escalation study data update: treatment with NXP900 resulted in exposure levels leading to robust pharmacodynamic responses across a range of tolerated doses; NXP900 has an acceptable safety profile, dose limiting toxicity dose level has not been identified in doses up to 250 mg/day Preclinical posters strengthen the NXP900 clinical development strategy as single agent in biomarker-targeted cancers and in combination with market leading therapies to overcome resistance in NSCLC Fort Lee, NJ ...

Core Viewpoint - Nuvectis Pharma, Inc. is advancing its clinical-stage drug candidate NXP900, a novel YES1/SRC kinase inhibitor, with upcoming presentations at the 2025 American Association for Cancer Research Meeting, highlighting its potential in treating advanced solid tumors and overcoming drug resistance in non-small cell lung cancer (NSCLC) [1][2]. Group 1: NXP900 Development - NXP900 is currently in a Phase 1a dose escalation study, demonstrating potent single-agent activity and synergy with ALK inhibitors in ALK-resistant NSCLC models [2][4]. - The drug targets YAP1 signaling in NSCLC cell lines and shows sensitivity in endocrine therapy-resistant luminal A breast cancer cell lines [2][4]. Group 2: Presentation Details - Nuvectis will present findings related to NXP900 in various sessions at the 2025 AACR Meeting, including "First-in-Human Phase I Clinical Trials" and "Drug Resistance in Molecular Targeted Therapies," scheduled for April 29th [3]. - Specific presentation times include sessions from 9:00 AM to 12:00 PM and 2:00 PM to 5:00 PM on the same day [3]. Group 3: Company Overview - Nuvectis Pharma, Inc. focuses on developing innovative precision medicines for serious unmet medical needs in oncology, with two clinical-stage candidates: NXP800 and NXP900 [4]. - NXP800 is an oral small molecule GCN2 activator in trials for platinum-resistant ovarian carcinoma and cholangiocarcinoma, while NXP900 is an oral small molecule inhibitor of the SRC Family of Kinases [4].

FORT LEE, NJ, March 14, 2025 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (“Nuvectis”, “Company”), a biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced that Ron Bentsur, Chairman and Chief Executive Officer, will participate in a fireside chat at the 37th Annual Roth Conference taking place March 17th-19th in Dana Point, California. Event37th Annual Roth ConferenceDateMarch 17, 2025Tim ...

Research conducted at the Lerner Research Institute, Cleveland Clinic (at Case Western Reserve University)Fort Lee, NJ, March 04, 2025 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced a new publication from the laboratory of Prof. Ruth Keri, (Cleveland Clinic, Cleveland, OH, US ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to . Commission File Number 001-41264 NUVECTIS PHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 86-2405608 (State or Other Juris ...