Core Viewpoint - Veracyte is focused on enhancing the understanding and treatment of cancer through advanced molecular diagnostics, aiming to empower physicians and improve patient outcomes globally [2]. Group 1: Company Mission and Approach - The company aims to change cancer treatment by delivering actionable clinical insights and enabling deep research [2]. - Veracyte employs a platform approach that emphasizes generating more data than necessary for clinical questions, utilizing whole transcriptome and whole genome-based assays [3]. - This data-driven strategy creates a flywheel effect, enhancing clinical utility and adoption, thereby expanding the company's reach to more patients [3].

Veracyte FY Conference Summary Company Overview - **Company**: Veracyte (NasdaqGM:VCYT) - **Industry**: Healthcare, specifically molecular diagnostics for cancer Core Points and Arguments Mission and Approach - Veracyte aims to enhance understanding and treatment of cancer through advanced molecular diagnostics, focusing on global patient access [2][3] - The company employs a platform approach to generate extensive data for each test, leading to greater clinical utility and adoption [3] Product Portfolio - Veracyte's tests cover multiple cancer types, including breast, prostate, bladder, and thyroid cancers, addressing the entire care continuum from risk assessment to monitoring [3][4] - The urology tests have shown significant growth, particularly after the introduction of the urology portfolio in 2021 [4] Financial Performance - Expected revenue for 2025 is projected between $515-$517 million, with a 17% growth in testing revenue driven by the Afirma and Decipher franchises [5][23] - The company anticipates achieving over 25% Adjusted EBITDA in 2025, indicating strong profitability [6][23] Decipher Test Insights - Decipher is a leading diagnostic for prostate cancer, with over 300,000 patients tested, and a 15% increase in ordering physicians in 2025 [8][9] - The test has a penetration rate of approximately 33%, indicating significant growth potential [9][27] - Decipher has delivered a three-year revenue CAGR of over 37% and is recognized in NCCN guidelines, supporting its adoption [10] Afirma Test Insights - Afirma helps patients with indeterminate thyroid nodules avoid unnecessary surgeries, with over 60% of tested patients spared from surgery [13] - The test has a penetration rate of 38% in the Bethesda 3 to 6 category, with growth driven by expanded reimbursement [13][14] Future Growth Drivers - Veracyte plans to launch new products, including True MRD for muscle-invasive bladder cancer and ProSigna for breast cancer, expanding its market reach [15][16][19] - The company aims to serve one million patients by 2026, demonstrating its impact on cancer care [24] Geographic Expansion - Veracyte is focused on expanding its tests internationally, with plans to develop ProSigna and Decipher as IVDs for European markets [21][22] Innovation and Research - The company emphasizes the importance of ongoing clinical evidence generation to support its tests, with a commitment to launching new tests annually [37][41] Additional Important Content - Veracyte's strong financial position, with nearly $400 million in cash and no debt, allows for organic growth and potential acquisitions [38] - The company is committed to addressing unmet clinical needs and driving research to enhance the understanding of cancer [40][41] This summary encapsulates the key points from Veracyte's FY Conference, highlighting the company's strategic focus on growth, innovation, and patient impact in the field of molecular diagnostics.

Financial Performance & Growth - Veracyte achieved approximately $516 million in total revenue for 2025, with a 17% testing revenue growth[12] - The company expects to achieve greater than 25% adjusted EBITDA in 2025[14] - Veracyte anticipates revenue between $570 million and $582 million in 2026, representing a 10-13% year-over-year growth[61] - The company projects a 14-16% year-over-year testing growth in 2026[61] - The company anticipates approximately 25% adjusted EBITDA margin in 2026[61] Product & Market Expansion - Over 800,000 patients have been served with Veracyte's tests to date[12] - Decipher Prostate has achieved approximately 33% market penetration in the U S[19] - Afirma has achieved approximately 38% market penetration in the U S thyroid cancer market[31] - The company plans to launch TrueMRD for muscle-invasive bladder cancer (MIBC) and Prosigna LDT in 2026[64] - Veracyte is developing IVD versions of its tests, including Decipher qPCR and Prosigna NGS, for geographic expansion[54]

Core Viewpoint - Veracyte, Inc. has announced preliminary, unaudited financial results for Q4 and the full year of 2025, indicating significant revenue growth compared to 2024 [1] Financial Results - For Q4 2025, Veracyte expects total revenue to be between $138 million and $140 million, reflecting an increase of 16% to 18% compared to the same period in 2024 [1]

Core Viewpoint - Veracyte, Inc. will present at the 44th Annual J.P. Morgan Healthcare Conference on January 15, 2026, at 9:45 a.m. Pacific Time [1] Group 1: Company Overview - Veracyte is a leading global diagnostics company focused on transforming cancer care for patients worldwide [3] - The company empowers clinicians with high-value insights to guide patients during critical moments in cancer diagnosis and treatment [3] - Veracyte's Diagnostics Platform offers high-performing cancer tests supported by extensive genomic and clinical data, advanced bioinformatics, AI capabilities, and a robust evidence-generation engine [3] Group 2: Presentation Details - Live audio webcasts of the company's presentations will be accessible on Veracyte's website [2] - A replay of the webcast will be available for 30 days after the live broadcast concludes [2]

Core Insights - Veracyte (VCYT) is experiencing significant growth in its Afirma business line and the Decipher franchise, although macroeconomic challenges pose risks to its operations [1][11]. Financial Performance - The company has a market capitalization of $3.41 billion and an earnings yield of 3.8%, outperforming the industry's -2.6% yield [2]. - Veracyte has consistently exceeded earnings estimates over the past four quarters, with an average surprise of 45.1% [2]. Business Highlights - The Afirma solution, including the Afirma GSC and Afirma Xpression Atlas, is effectively addressing thyroid nodule diagnosis, with a 13% volume growth in Q3 2025 driven by new account wins and increased utilization [3][4][9]. - The Decipher franchise has expanded into bladder cancer, with the Decipher Bladder test being the first genomic test covered by Medicare, contributing to a total of approximately 26,700 tests performed in Q3 2025, marking 14 consecutive quarters of over 25% year-over-year volume growth [5][6][9]. - Veracyte ended Q3 2025 with cash and cash equivalents of $366 million and no debt, indicating a strong liquidity position [7][10]. Cost and Economic Challenges - The company faces macroeconomic challenges, including rising interest rates and inflation, which have led to an 11.6% year-over-year increase in total cost of revenues, with selling and marketing expenses rising by 8.1% to $24.5 million [11].

Market Overview - U.S. stock futures showed mixed results, with Dow futures decreasing approximately 0.1% on Monday [1] Company-Specific Movements - Meihua International Medical Technologies Co., Ltd. (NASDAQ:MHUA) announced its delisting from Nasdaq, leading to a significant pre-market decline of 32.9%, bringing shares down to $9.41 [1] - SMX (Security Matters) Public Limited Company (NASDAQ:SMX) shares fell 17.2% to $275.00 after a substantial increase of 135% on the previous Friday [3] - Gulf Resources, Inc. (NASDAQ:GURE) saw a decline of 16.1% to $6.87 following a 4% drop on Friday [3] - Wheeler Real Estate Investment Trust, Inc. (NASDAQ:WHLR) shares decreased by 16.1% to $5.35 after a notable surge of 98% on Friday [3] - Fly-E Group, Inc. (NASDAQ:FLYE) experienced a 14.4% drop to $7.08 after receiving a delinquency notice from Nasdaq regarding a delayed Form 10-Q [3] - Ecarx Holdings Inc. (NASDAQ:ECX) shares fell 9.1% to $1.91 after an 8% gain on Friday [3] - Arteris Inc (NASDAQ:AIP) saw a decline of 7.1% to $16.30 in pre-market trading [3] - Veracyte Inc (NASDAQ:VCYT) shares decreased by 5.7% to $42.06 after a 6% decline on Friday [3] - Chagee Holdings Ltd (NASDAQ:CHA) shares fell 4.6% to $13.91 in pre-market trading [3] - PureTech Health PLC (NASDAQ:PRTC) experienced a 4.2% decline to $17.30, despite announcing a successful end-of-Phase 2 meeting with the FDA for Deupirfenidone (LYT-100) in Idiopathic Pulmonary Fibrosis [3] - PepGen Inc (NASDAQ:PEPG) shares declined by 3.9% to $5.23 in pre-market trading [3]

Market Overview - U.S. stock futures showed mixed results, with Dow futures decreasing approximately 0.1% on Monday [1] Company-Specific Movements - Meihua International Medical Technologies Co., Ltd. (NASDAQ:MHUA) announced its delisting from Nasdaq, leading to a significant pre-market decline of 32.9%, bringing shares down to $9.41 [1] - SMX (Security Matters) Public Limited Company (NASDAQ:SMX) shares fell 17.2% to $275.00 after a substantial increase of 135% on the previous Friday [3] - Gulf Resources, Inc. (NASDAQ:GURE) saw a decline of 16.1% to $6.87 following a 4% drop on Friday [3] - Wheeler Real Estate Investment Trust, Inc. (NASDAQ:WHLR) shares decreased by 16.1% to $5.35 after surging 98% on Friday [3] - Fly-E Group, Inc. (NASDAQ:FLYE) experienced a 14.4% drop to $7.08 after receiving a delinquency notice from Nasdaq regarding a delayed Form 10-Q [3] - Ecarx Holdings Inc. (NASDAQ:ECX) shares fell 9.1% to $1.91 after an 8% gain on Friday [3] - Arteris Inc (NASDAQ:AIP) saw a decline of 7.1% to $16.30 in pre-market trading [3] - Veracyte Inc (NASDAQ:VCYT) shares decreased by 5.7% to $42.06 after a 6% decline on Friday [3] - Chagee Holdings Ltd (NASDAQ:CHA) shares fell 4.6% to $13.91 in pre-market trading [3] - PureTech Health PLC (NASDAQ:PRTC) declined 4.2% to $17.30 despite announcing a successful end-of-Phase 2 meeting with the FDA for Deupirfenidone (LYT-100) in Idiopathic Pulmonary Fibrosis [3] - PepGen Inc (NASDAQ:PEPG) shares decreased by 3.9% to $5.23 in pre-market trading [3]

Core Insights - Zacks Premium offers tools for investors to enhance their stock market strategies, including daily updates on Zacks Rank and Industry Rank, research reports, and stock screens [1][2] Zacks Style Scores - Zacks Style Scores are indicators that rate stocks based on value, growth, and momentum characteristics, helping investors identify stocks likely to outperform the market in the next 30 days [2][3] - Each stock is rated from A to F, with A indicating the highest potential for outperformance [3] Value Score - The Value Style Score focuses on identifying undervalued stocks using financial ratios such as P/E, PEG, and Price/Sales [3] Growth Score - The Growth Style Score assesses a company's financial health and future outlook, analyzing projected and historical earnings, sales, and cash flow [4] Momentum Score - The Momentum Style Score evaluates stocks based on price trends and earnings estimate changes, aiding investors in timing their purchases [5] VGM Score - The VGM Score combines all three Style Scores, providing a comprehensive indicator for investors seeking attractive value, growth, and momentum [6] Zacks Rank - The Zacks Rank is a proprietary model that uses earnings estimate revisions to help investors build successful portfolios, with 1 (Strong Buy) stocks achieving an average annual return of +23.93% since 1988 [7][10] - Stocks with a Zacks Rank of 1 or 2 and Style Scores of A or B are recommended for the highest probability of success [9] Company Spotlight: Veracyte (VCYT) - Veracyte is a diagnostics company specializing in cancer detection, offering advanced genomic tests for various cancers [11] - VCYT holds a 1 (Strong Buy) Zacks Rank and a VGM Score of B, with a Growth Style Score of B indicating a projected year-over-year earnings growth of 38.7% for the current fiscal year [12] - The Zacks Consensus Estimate for VCYT's earnings has increased by $0.23 to $1.65 per share, with an average earnings surprise of +45.1% [12][13]

Veracyte FY Conference Summary Company Overview - **Company**: Veracyte (NasdaqGM:VCYT) - **Industry**: Medtech and Diagnostics Key Financial Highlights - **Q3 Revenue**: Over $131 million, a growth of 14% year-over-year [4] - **Testing Business Growth**: Grew by 17%, with Decipher achieving over 25% growth for 14 consecutive quarters [4] - **Afirma Growth**: Volume increased by 13%, driven by new accounts and deeper penetration into existing accounts [4] - **Adjusted EBITDA**: Reached 30% for the quarter, exceeding expectations, with a forecast to finish the year over 25% [5] Decipher Product Insights - **Market Penetration**: Estimated at 40%, indicating room for growth [7] - **Durability of Growth**: Anticipated demand increase due to the recent launch of the metastatic indication and ongoing clinical trials [8][10] - **Physician Ordering Dynamics**: Changes in how tests are ordered, with a focus on building trust and integrating test ordering into clinical workflows [11][12] NCCN Guidelines Impact - **Guideline Inclusion**: The inclusion of Decipher in NCCN guidelines has provided a tailwind for growth, although isolating the impact from other factors is challenging [14] Digital Pathology and Competitive Landscape - **Digital Pathology Positioning**: Emphasized as complementary to existing tests, with a focus on avoiding confusion among clinicians [16] - **Discordance with Competitors**: Noted a 30% discordance rate between Decipher and a competing test, highlighting Decipher's validation and reliability [18][19] Future Product Developments - **V2 Transcriptome Transition**: Aiming for full transition by the end of the year, expected to enhance efficiency and reduce test failures [29][30] - **Prosigna LDT Launch**: Planned for mid-2026, with a focus on building a commercial team and engaging key opinion leaders [42][43] Market Strategy and Growth Drivers - **Growth Drivers**: Focus on Afirma, Decipher, Prosigna, MRD, and IBD, with a balanced approach to investment and growth [62] - **Market Penetration Goals**: Targeting 80% penetration in the market, currently at 65% [28] Capital Allocation and M&A Strategy - **Cash Position**: Expected to be close to $400 million with no debt, allowing for strategic investments and potential M&A opportunities [70] - **M&A Focus**: Prioritizing investments in core business areas before considering acquisitions [71] Conclusion - Veracyte is positioned for continued growth with strong financial performance, innovative product offerings, and a strategic focus on market penetration and operational efficiency. The company is actively engaging in expanding its product portfolio while maintaining a disciplined approach to capital allocation and investment in growth drivers.