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CXO行业深度报告:触底回升、拐点已现,供需格局改善催化新一轮上升周期
兴业证券·2024-12-31 04:21

Investment Rating - The industry rating is "Recommended (Maintain)" for the CXO sector, indicating an upward trend in the supply-demand balance and a potential recovery phase [52]. Core Insights - The CXO industry is experiencing a recovery phase, with supply clearing and improving demand conditions expected to catalyze a new upward cycle [52][56]. - The demand for large molecule CDMO services is robust, driven by the increasing commercialization of ADCs, bispecific antibodies, and other new molecular entities [2][115]. - The global small molecule CDMO market is projected to grow significantly, with a CAGR of 15.5%, reaching 106.7billionby2028[77].ThecompetitivelandscapeforlargemoleculeCDMOisbecomingincreasinglyconcentrated,withmajorplayerslikeLonza,WuXiBiologics,andSamsungBiologicscapturingsignificantmarketshares[139][140].SummarybySectionsCXOIndustryOverviewTheCXOsectorsrevenueforthefirstthreequartersof2024was67.06billionyuan,ayearonyeardecreaseof8106.7 billion by 2028 [77]. - The competitive landscape for large molecule CDMO is becoming increasingly concentrated, with major players like Lonza, WuXi Biologics, and Samsung Biologics capturing significant market shares [139][140]. Summary by Sections CXO Industry Overview - The CXO sector's revenue for the first three quarters of 2024 was 67.06 billion yuan, a year-on-year decrease of 8%, primarily due to lower demand in the domestic innovative drug sector and increased competition [56]. - The gross and net profit margins for the CXO sector were 38.3% and 16.4%, respectively, reflecting a decline compared to the previous year [95]. Large Molecule CDMO - Major players in the large molecule CDMO sector are expanding their capacities significantly, with Lonza's acquisition of the Vacaville site adding 332,000 liters of capacity [1][140]. - The global market for large molecule CDMO is expected to see a concentration of capacity among top players, with the top four companies projected to hold 64% of the market share by 2025 [120]. Small Molecule CDMO - The small molecule CDMO market is expected to maintain steady growth, with China's CDMO sector continuing to expand its lead over India in terms of capacity and quality [77][132]. - The global small molecule CDMO market size reached 51.9 billion in 2023, with expectations of significant growth driven by stable R&D investments from large pharmaceutical companies [77]. Clinical and Preclinical CRO - The clinical CRO sector is facing challenges due to high project cancellation rates, but there are signs of recovery as demand from large pharmaceutical companies remains stable [15][30]. - The clinical and preclinical CRO markets are expected to see improvements as the demand environment stabilizes and funding for biotech companies begins to recover [30][47]. Supply Chain and Capacity Expansion - The industry is focusing on building a global production network to enhance supply chain security, with companies like WuXi Biologics and Fujifilm expanding their facilities in Europe and North America [42]. - The CXO industry is transitioning from a phase of rapid capacity expansion to a more stable development phase, with capital expenditures declining significantly [72][154].