AKESO(09926) 华泰证券·2025-04-24 02:19Investment Rating - The investment rating for the company is "Buy" with a target price of HKD 115.25 [8][5]. Core Views - The mid-term analysis of AK112-306 shows strong positive results, marking the second head-to-head positive outcome for the drug in the NSCLC field, indicating a promising future for the drug in lung cancer treatment [1][2]. - The drug has demonstrated significant benefits in first-line sqNSCLC patients, regardless of PD-L1 expression, with a notable safety profile [2][3]. - The company is expected to accelerate its global clinical trials, with positive results from AK112-306 likely to expedite the HARMONi-3 study [3][4]. - The company anticipates that the application for the drug's approval for 1L PD-L1 positive NSCLC in China will be submitted soon, with multiple ongoing Phase III trials for other indications [4][5]. Financial Projections and Valuation - The company has adjusted its net profit forecasts for 2025-2027 to RMB 0.76 billion, RMB 6.62 billion, and RMB 14.16 billion, respectively, reflecting an increase in the success rate of developing the 1L PD-L1 negative NSCLC indication [5][13]. - The projected revenue for 2025 is RMB 3.35 billion, with a significant increase expected in subsequent years [20][21]. - The DCF valuation method estimates the company's fair value at approximately RMB 970 billion, with a target price adjustment to HKD 115.25 [5][13].