Cidara Therapeutics (CDTX) 2025 Conference May 07, 2025 11:00 AM ET Speaker0 Alright. Thank you everybody again for joining us, Citizens Life Science Conference here. We, next company we have is Sadara Therapeutics, and we have Jeff Stein is president and CEO and a co founder. Frank Carbe, CFO, was going to be here, had some travel related issues, but we're happy to have Jeff here to walk us through the Sadara story. Pretty exciting few weeks coming up definitely with a phase two b breed out at the June. So ...

Resideo (REZI) FY Conference May 07, 2025 10:30 AM ET Speaker0 Okay. Thank you, everybody. Welcome to the Oppenheimer Industrial Conference. I am Ian Zaffino. I am the equity research analyst that covers Resideo. I've been covering them since they spun out of Honeywell. With me today is Tom Saran, the company's president of products and solutions, and also Mike Cartlett, is the company's CFO. Guys, thank you very much for being here today. We really appreciate it. Speaker1 Thanks, Ian. Thanks for having us. ...

Astria Therapeutics (ATXS) 2025 Conference May 07, 2025 10:30 AM ET Speaker0 Morning, everybody, and welcome to day one of the Citizens Life Science Conference. My name is John Wallabin, senior analyst here. We're pleased to have Astria Therapeutics and CEO, Jill Millney, joining us today. Astria is a company we launched coverage on, I think, earlier this year in January. We've been covering the hereditary angioedema space for quite some time, and I think this is one of the more compelling pipeline candidat ...

Snap-on (SNA) FY Conference May 07, 2025 10:30 AM ET Speaker0 Thank you, Annie, and welcome everyone to our Generac fireside session. Special thanks to Nick Aldo and Sarah for joining from Generac and glad to have you guys back at the conference. Thanks for participating. So I think wanted to kick off with sort of a high level kind of frame up type question then get into some of the comings and goings of the business model and the market backdrops. But Nick, maybe if you could discuss Snap on's market posit ...

McGrath RentCorp (MGRC) FY Conference May 07, 2025 10:30 AM ET Speaker0 Hey. Good morning, everyone. I'm Scott Schneeberger, senior business and industrial services analyst at Oppenheimer. Thank you all for joining us today. It's my pleasure to have from McGrath, with us today, the CFO, of excuse me. The CEO, Johanna, the CFO, Keith Pratt, and the COO, Phil Hawkins. We look forward to hearing the story. McGrath rents and sells modular office and classrooms and portable storage containers and electronic test ...

Cytokinetics (CYTK) 2025 Conference May 07, 2025 10:00 AM ET Speaker0 So I'm excited to be joined next at the Citizens Life Science Conference by Cytokinetics. Cytokinetics is a special specialty cardiology company with a focus on muscle biology. Really exciting time for the company with, Aficampton, PDUFA date. It's just several months away now. Obviously, lots of discussion over the last week about the the PDUFA extension, so we'll jump into that. But Robert and team just welcome and maybe I'll just ask y ...

Bioatla (BCAB) 2025 Conference May 07, 2025 10:00 AM ET Speaker0 Alright. Well, good morning, and, welcome to the annual Citizens Life Science Conference. It's my pleasure to introduce the next presenting company, BioAtla. Joining us on the stage is the team from BioAtla, Jay Short, CEO, joined by Eric Sievers, CMO, Sherry Leidich, chief commercial officer, and Rick Waldron, CFO. So welcome everyone. Appreciate you guys being here. Speaker1 Thank you, Rudy. Speaker0 I I never know who exactly is in the audi ...

scPharmaceuticals (SCPH) 2025 Conference May 07, 2025 09:30 AM ET Speaker0 Everybody, thank you for joining us at the Citizens Life Science Conference. I'm Jason Butler. I'm one of the biopharma analysts here at Citizens. Excited to kick off this conference this week. Specifically excited to be joined by our first company SC Pharmaceuticals. SC Pharma is a company focused on the cardio renal space, is launching a product called Furosex. Had an exciting announcement just a few weeks ago with a label expansio ...

Summary of Altimmune (ALT) Conference Call Company Overview - **Company**: Altimmune - **Focus**: Development of GLP-1 glucagon dual agonist, pembidutide, for multiple indications including NASH (Non-Alcoholic Steatohepatitis) and obesity [7][8] Core Points and Arguments - **Drug Mechanism**: Pembidutide leverages a dual mechanism of action targeting both the liver and weight loss, crucial for treating NASH, where 80% of patients are also obese [8][9] - **Clinical Data**: - Phase 2b data for NASH is expected soon, with a focus on liver health and weight loss [8] - Previous Phase II studies showed a 15.6% weight loss at 48 weeks and a 20% reduction in LDL cholesterol, indicating potential synergy with statins [24][25] - Class-leading liver fat reduction of 76% at 24 weeks, the highest among drugs in development for NASH [26][41] - **Safety Profile**: Over 500 subjects have been exposed to pembidutide, confirming its safety for glycemic control and cardiovascular health, with no major adverse cardiovascular events reported [22][23] - **Regulatory Engagement**: The FDA has acknowledged the safety profile and glycemic control of pembidutide, which is designed to be glucose neutral [18][22] Industry Context - **Resurgence of Glucagon**: The importance of glucagon in obesity and metabolic diseases is being recognized, with multiple companies exploring its benefits [12][14] - **Market Positioning**: Pembidutide is positioned as a comprehensive solution for NASH, combining weight loss and direct liver effects, unlike other agents that only address one aspect [62] Additional Insights - **Patient Selection and Study Design**: The IMPACT trial is designed with 190 subjects, focusing on a 1.8 mg dose compared to placebo, with a robust methodology to minimize bias in biopsy readings [27][28] - **Long-term Effects**: The combination of glucagon and weight loss is expected to yield compounding benefits over time, enhancing treatment outcomes for NASH patients [39][43] - **Future Indications**: Altimmune plans to explore pembidutide for alcohol use disorder (AUD) and alcoholic liver disease (ALD), leveraging its ability to reduce cravings and heal liver inflammation [63][64] Financial Position - **Cash Position**: At the end of 2024, Altimmune expects to have approximately $132 million, sufficient to support ongoing and upcoming milestones, including new indications [68] Upcoming Events - **Earnings Call**: A full update on data and financials is expected in the upcoming earnings call, with significant data anticipated in the second quarter [66][68]

Summary of AN2 Therapeutics (ANTX) Conference Call Company Overview - **Company**: AN2 Therapeutics (ANTX) - **Focus**: Development of novel therapeutics for infectious diseases and oncology Key Points Novel Drug Development - AN2 Therapeutics is developing two novel compounds targeting previously unaddressed areas in human medicine: one antibacterial and one antiparasitic [1] - The company is leveraging boron chemistry to expedite drug development, which has favorable pharmacokinetic properties and operates in a less crowded intellectual property space [1][2] Chagas Disease Treatment - The oral candidate AN2502998 is in phase one trials, targeting Chagas disease, which affects approximately seven million people globally, with significant cardiac complications in about 30% of patients [6][8] - The drug is expected to provide a cure for chronic Chagas disease, with a potential market opportunity estimated at over one billion dollars [15] - The company plans to implement a "test and treat" strategy to increase awareness and diagnosis of Chagas disease in the U.S. [17] Regulatory Path and Clinical Trials - AN2 Therapeutics anticipates a streamlined regulatory path due to the high unmet need for Chagas disease treatment, planning a Phase II and pivotal Phase III trial [19][21] - The company has a contract with the NIH for $18 million to support a phase two proof of concept study for melioidosis, a serious infectious disease with high mortality rates [25][26] Oncology Programs - AN2 is entering the oncology space with two targets utilizing boron chemistry, focusing on ENPP1, which is involved in cancer metastasis, and PI3 kinase alpha, which has significant competition [40][41] - The company believes it can develop best-in-class compounds with unique binding properties and a strong intellectual property position [46][48] Market Potential and Competitive Landscape - The market for abscessus, a type of NTM infection, is estimated to be a multibillion-dollar opportunity, with a significant patient population in the U.S. and Japan [34] - AN2 aims to differentiate its oncology drugs through unique chemistry and a strong IP position, avoiding crowded spaces with overlapping structures [47][48] Financial Position - The company has sufficient cash reserves to fund operations and development through 2028, allowing for multiple avenues of growth despite recent setbacks in NTM drug development [48] Additional Insights - The company emphasizes the importance of addressing neglected tropical diseases and the potential for significant patient impact alongside commercial opportunities [9][29] - AN2 is committed to advancing its drug candidates quickly, with plans for rapid clinical trials and a focus on patient outcomes [14][20][37]