Group 1 - The company, SiHuan Pharmaceutical (00460.HK), expects to achieve revenue of no less than RMB 2.5 billion for the fiscal year ending December 31, 2025, representing a growth rate of over 30% compared to the same period last year [1] - The anticipated net profit for the same fiscal year is projected to be no less than RMB 150 million [1] - As of February 10, 2026, SiHuan Pharmaceutical's stock closed at HKD 1.67, down 1.76%, with a trading volume of 46.33 million shares and a turnover of HKD 78.42 million [1] Group 2 - The stock is primarily rated as a "buy" by investment banks, with two firms issuing buy ratings in the last 90 days [1] - The average target price for the stock over the past 90 days is HKD 1.6 [1] - Guohai Securities has recently issued a buy rating for SiHuan Pharmaceutical [1] Group 3 - SiHuan Pharmaceutical has a market capitalization of HKD 15.548 billion and ranks 10th in the chemical pharmaceutical industry [1]

Group 1 - The company expects to achieve revenue of no less than RMB 2.5 billion in the fiscal year 2025, representing a growth rate of over 30% compared to the same period last year [1] - The company anticipates a net profit of no less than RMB 150 million for the fiscal year 2025 [1] - The medical beauty business is projected to generate over RMB 1.4 billion in revenue and over RMB 700 million in segment profit for the fiscal year 2025, with both revenue and segment profit growth rates exceeding 90% compared to the previous year [1]

Core Viewpoint - The company anticipates achieving revenue of no less than RMB 2.5 billion and net profit of no less than RMB 150 million for the fiscal year ending December 31, 2025, representing a growth rate of over 30% compared to the previous year [1] Group 1: Financial Performance - The aesthetic medicine business is expected to generate over RMB 1.4 billion in revenue and over RMB 700 million in segment profit, with both metrics showing an annual growth rate exceeding 90%, becoming the primary revenue and profit driver for the company [1] - The innovative drug business is entering a harvest phase, with significant revenue growth from Xuan Zhu Bio and Hui Sheng Bio, and a transition from investment to revenue generation, improving the company's profit structure [1] - The company maintains a robust financial position with ample cash reserves, implementing multiple rounds of share buybacks and successfully spinning off Xuan Zhu Bio, which enhances equity value and alleviates R&D funding pressure [1] Group 2: Aesthetic Medicine Sector - The company has successfully obtained approvals for several self-developed core products, including various injectables and devices, establishing itself as a comprehensive aesthetic medicine enterprise [2] - The market share of the core product, Le Ti Bao botulinum toxin, has increased to nearly 20%, with partnerships exceeding 8,000 medical aesthetic institutions, driving rapid sales growth of newly launched products [2] - The company is advancing its global strategy by signing an investment agreement with Swiss aesthetic company Suisselle, aiming to penetrate the EU market and solidify its long-term growth foundation [2] Group 3: Pharmaceutical R&D Progress - Rapid advancements in pharmaceutical R&D are evident, with Xuan Zhu Bio's ALK inhibitor and CDK4/6 inhibitor receiving market approvals, and Xuan Yue Ning being included in the national medical insurance directory [3] - The company achieved a successful spin-off listing of Xuan Zhu Bio on the Hong Kong Stock Exchange, providing significant equity value gains and easing R&D investment pressures [3] - This strategic move supports the company's focus on high-growth sectors like aesthetic medicine, facilitating a transition to a new phase of high-quality development [3]

Core Viewpoint - The company expects to achieve revenue of no less than RMB 2.5 billion and net profit of no less than RMB 150 million for the fiscal year ending December 31, 2025, representing a year-on-year revenue growth of over 30% [1] Financial Performance Factors - The aesthetic medicine business is projected to achieve revenue exceeding RMB 1.4 billion and segment profit over RMB 700 million, with both revenue and profit growth rates exceeding 90% year-on-year, becoming the largest revenue and profit contributor to the group [2] - The innovative drug business is entering a harvest phase, with significant revenue growth from Xuan Zhu Bio and Hui Sheng Bio, and a transition from investment to revenue generation, improving the group's profit structure [2] - The company maintains a robust financial position with ample cash reserves, implementing multiple rounds of share buybacks and successfully spinning off Xuan Zhu Bio, which enhances equity value and alleviates R&D funding pressure [2] Aesthetic Medicine Segment - The company has successfully obtained approvals for several self-developed core products, including the "Youthful Needle" and "L-Arginine Facial Energy Essence," establishing itself as a comprehensive aesthetic medicine enterprise [3] - The market share of the core product, "Le Ti Bao Botulinum Toxin," has increased to nearly 20%, with partnerships exceeding 8,000 medical aesthetic institutions, driving rapid sales growth of newly launched products [3] - The company is accelerating its global expansion, having signed an investment subscription agreement with Swiss aesthetic company Suisselle, aiming to penetrate the EU market and establish a sustainable growth foundation [3] Pharmaceutical R&D Progress - Rapid advancements in R&D are noted, with Xuan Zhu Bio and Hui Sheng Bio achieving significant milestones, including the approval of ALK inhibitor Xuan Fei Ning and CDK4/6 inhibitor Xuan Yue Ning, with the latter included in the national medical insurance directory [4] - The successful spin-off of Xuan Zhu Bio on the Hong Kong Stock Exchange has provided substantial equity value gains and eased R&D investment pressures, allowing the company to focus resources on high-growth sectors like aesthetic medicine [4]

Core Viewpoint - The company expects to achieve a revenue of no less than RMB 2.5 billion and a net profit of no less than RMB 150 million for the fiscal year ending December 31, 2025, reflecting a growth rate of over 30% compared to the previous year [1] Group 1: Financial Performance - The company's aesthetic medicine business is projected to generate over RMB 1.4 billion in revenue and over RMB 700 million in segment profit, with both metrics showing an annual growth rate exceeding 90% [1] - The innovative drug business is entering a harvest phase, with significant revenue growth from Xuan Bamboo Biotechnology and Hui Sheng Biotechnology, improving the company's profit structure [1] - The company maintains a strong financial position with ample cash reserves, enabling multiple rounds of share buybacks and the successful spin-off of Xuan Bamboo Biotechnology, which alleviates R&D funding pressure [1][4] Group 2: Product Development and Market Position - The company has successfully obtained approvals for several self-developed core products in the aesthetic medicine sector, including various injectables and devices, establishing itself as a comprehensive player in the industry [2] - The market share of the core product, Le Ti Bao botulinum toxin, has increased to nearly 20%, with partnerships extending to over 8,000 aesthetic institutions [2] - The company is accelerating its global expansion, having signed an investment agreement with Swiss aesthetic company Suisselle to introduce its products to the EU market, thereby establishing a closed-loop market presence in Europe and the US [3] Group 3: Future Outlook - The company plans to deepen its strategic focus on aesthetic medicine, with seven products currently in the registration application stage and several others in late clinical phases, ensuring a robust pipeline for future growth [3] - The successful spin-off of Xuan Bamboo Biotechnology in October 2025 is expected to provide significant equity appreciation and support the company's focus on high-growth sectors like aesthetic medicine [4]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 Sihuan Pharmaceutical Holdings Group Ltd. 四環醫藥控股集團有限公司 – 1 – 2025年 是 四 環 醫 藥 業 績 實 現 關 鍵 拐 點 的 一 年。該 年 度 內，本 集 團 多 款 醫 美 及 醫 藥 新 產 品 相 繼 獲 批 上 市，業 務 結 構 與 市 場 競 爭 力 實 現 顯 著 提 升。 醫 美 板 塊 方 面，本 集 團 多 款 自 研 核 心 產 品 成 功 獲 批，包 括 自 研 童 顏 針（回 顏 臻®、 斯弗妍®）、自 研 少 女 針（傾 研®）、自 研 含L－肌 肽 面 部 動 能 素（凍 妍®）等。隨 著 多 款 自 研 再 生 類、水 光 類 產 品 陸 續 上 市，四 環 醫 藥 已 成 為 行 業 內 首 家 集 齊 肉 毒 毒 素、少 女 針、童 顏 針、水 光 ...

Investment Rating - The report maintains an "Outperform" rating for the pharmaceutical industry [3] Core Insights - The commercialization of ADC (Antibody-Drug Conjugates) is accelerating, with 20 ADC drugs approved globally, and 6 of them have been in the "billion-dollar club" for two consecutive years [30][31] - The report highlights the increasing competition in the ADC sector, with approximately 60 ADC drugs currently in clinical phase 3 and application stages [30] - Domestic innovative pharmaceutical companies are adopting various strategies for ADC capacity layout, with companies like Rongchang Biopharma transitioning from outsourcing to in-house production, while others like Kelong Biotechnology are building their own production bases [31][32] Summary by Sections Market Review - The pharmaceutical index rose by 0.14% this week, outperforming the CSI 300 index by 1.47 percentage points, ranking 15th in industry performance [10] - Year-to-date, the pharmaceutical index has increased by 3.28%, also outperforming the CSI 300 index by 2.99 percentage points, ranking 23rd [10] Individual Stock Performance - In the A-share market, 255 out of 479 pharmaceutical stocks rose, with the top five performers being Guangshengtang (+29.83%), Haixiang Pharmaceutical (+18.64%), and Meidixi (+18.04%) [20] - In the Hong Kong market, 38 out of 116 pharmaceutical stocks rose, with the top performers including Yiteng Jiahe (+14%) and Kedi-B (+9.96%) [24] Industry News and Policies - The newly revised "Regulations on the Implementation of the Drug Administration Law" supports segmented contract manufacturing and commercial-scale drug sales, providing a foundation for ADC commercialization cooperation [32] - Notable industry developments include Novartis's application for Ianalumab in China and Johnson & Johnson's approval of Daratumumab injection for multiple myeloma treatment [27][28] Weekly Insights - The ADC commercialization battle has begun, with a significant increase in demand for ADC production capacity, leading to a supply-demand imbalance [30] - Major CXO companies are expanding ADC production capacity, with companies like WuXi AppTec acquiring East Yao Pharmaceutical to meet rising orders [31]

Investment Rating - The report recommends a focus on the company, indicating that it is undervalued with a reasonable valuation range of over HKD 25 billion [21]. Core Insights - The company has transitioned from traditional generic drugs to a dual-driven strategy focusing on "aesthetic medicine and innovative drugs," leading to a significant revenue increase in the aesthetic segment [21]. - The aesthetic medicine segment saw a revenue increase of 81% year-on-year in the first half of 2025, contributing significantly to the company's overall revenue growth [4][11]. - The innovative drug segment is expected to enter a revenue realization phase with the commercialization of new drugs, enhancing the company's financial outlook [12][16]. Summary by Sections Aesthetic Medicine - In H1 2025, aesthetic medicine revenue increased by 81% to HKD 5.9 billion, with a gross margin improvement of 8 percentage points to 73% [4][11]. - The core product, Letybo (botulinum toxin), has a market penetration of less than 2% in China, indicating substantial growth potential compared to higher penetration rates in the US and South Korea [5]. - The company has three major products approved in 2025, including facial fillers and water light needles, which are expected to drive significant sales growth [9][10]. Innovative Drugs - The innovative drug segment reported a 30% revenue increase to HKD 0.17 billion in H1 2025, with a focus on gastrointestinal and oncology treatments [12]. - The company has successfully commercialized its first innovative PPI drug, which is expected to maintain its price in the national basic medical insurance directory [12][14]. - The company holds a 49.13% stake in Xuan Zhu Bio, which has a market capitalization of HKD 34.5 billion, further enhancing its financial position [12]. Biopharmaceuticals - The biopharmaceutical segment, focusing on diabetes, has a comprehensive pipeline with over 20 products, and revenue is expected to see explosive growth in the next 2-3 years [17][18]. - The company reported a 40-fold increase in revenue to HKD 0.39 billion in H1 2025, with a focus on insulin and innovative diabetes treatments [17][18]. Generic Drugs - Generic drug revenue decreased by 16% to HKD 5.0 billion in H1 2025, accounting for 44% of total revenue, but the impact is expected to lessen as aesthetic and innovative drug segments grow [19]. - Key products include Clinao (a unique injection) and a mucosal solution for children, which are positioned to capture niche markets [19]. Profit Forecast - The company is expected to turn profitable in 2025, with significant revenue growth driven by aesthetic and innovative drugs, alongside reduced R&D expenses [20]. - The company has maintained a high dividend payout ratio of 89% in H1 2025, reflecting strong cash flow management [20].

近日，四环医药旗下渼颜空间自主研发的聚乳酸面部填充剂（俗称"童颜针"）的6个新增规格获国家药监局正式获批，覆盖60mg/瓶至130mg/瓶多梯度剂量， 进一步丰富医美管线矩阵。 回顾2025年，四环医药作为中国医美龙头，通过全品类产品矩阵形成稀缺竞争壁垒、全域渠道网络筑牢市场根基、营收规模逆势领跑行业、丰富研发管线保 障长期迭代、药企基因赋能品牌合规优势，形成穿越行业周期、实现逆势高增的核心底气。 而从估值角度来看，当前公司的价值与价格存在明显倒挂，被市场显著低估，长期成长潜力有望得到进一步重估。 五大核心维度，彰显四环医药医美龙头优势 契合医美行业向合规化、技术化、全品类化转型的核心趋势，四环医药凭借产品、渠道、规模、研发、品牌五大维度的全方位硬实力支撑，在奠定其医美头 部地位的同时，更形成了同行较难复制的竞争护城河。 其四，研发端加快迭代升级，保障长期成长动能。 研发能力决定医美企业的长期生命力，四环医药持续加大医美领域研发投入，构建丰富且高质量的研发管线。数据显示，2025年行业新获批产品中80%来自 具备三类械资质的头部企业，中小玩家加速出清。四环医药2025年全年新增3款重磅三类械产品，包括童颜针、 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2026年1月31日 狀態: 新提交 FF301 致：香港交易及結算所有限公司 呈交日期: 2026年2月2日 I. 法定/註冊股本變動 公司名稱: 四環醫藥控股集團有限公司 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 00460 | 說明 | 普通股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 100,000,000,000 | HKD | | 0.01 | HKD | | 1,000,000,000 | | 增加 / 減少 (-) | | | | | | | HKD | | | | 本月底結存 | | | 100,000,000,000 | HKD | | 0.01 | HKD | | 1,00 ...