Core Viewpoint - The article presents a list of 12 stocks that are recommended for investment during the countdown to the new year, highlighting their long-term growth potential and current market conditions. Group 1: Recommended Stocks - **Apple**: Expected to achieve an 11% gain for the year, with a strong brand and growing AI integration across products, which may drive future revenue growth [5][6]. - **Costco**: Trading at 43x forward earnings estimates, down from over 58x, with a strong business model and high membership renewal rates above 90% in the U.S. and Canada [7][9]. - **Carnival**: The world's largest cruise operator has returned to profitability and is paying down debt, trading at only 11x forward earnings estimates [11][12]. - **Intuitive Surgical**: A leader in robotic surgery with a strong moat due to high costs of its systems and recurrent revenue from instruments and accessories [13][15]. - **Vertex Pharmaceuticals**: Leading in cystic fibrosis treatment with strong revenue and growth potential in new treatment areas [16][18]. - **Coca-Cola**: Strong brand and distribution network with a history of dividend increases for over 50 consecutive years, making it a solid choice for passive income [19][20]. - **Pool Corp.**: The largest supplier of pool equipment, trading at 22x forward earnings estimates, with consistent demand for maintenance services [21][22]. - **Amazon**: A leader in e-commerce and cloud computing, benefiting from AI growth, with AWS reporting a $132 billion annual revenue run rate [24][25]. - **Target**: Facing challenges but may recover in 2026, trading at 13x forward earnings estimates, presenting a potential buying opportunity [27][28]. - **CRISPR Therapeutics**: Recently approved a blood disorder treatment, with expected significant growth in the coming year [29][30]. - **Broadcom**: A networking giant emerging as a potential AI chip winner, with high demand for custom chips [31][32]. - **Taiwan Semiconductor Manufacturing**: A key player in chip production for AI, benefiting from multiple clients and significant investments in U.S. manufacturing [33][34].

Core Viewpoint - Healthcare stocks have underperformed compared to broader equities this year, but there are still attractive investment opportunities in the sector for long-term investors [1] Group 1: CRISPR Therapeutics - CRISPR Therapeutics is a gene-editing company with potential catalysts for stock price growth, particularly with its therapy Casgevy for sickle cell disease and beta-thalassemia [4] - The company has been enhancing third-party coverage and establishing treatment centers for Casgevy, which is expected to see significant growth next year [5] - CRISPR is also developing SRSD107, a potential anticoagulant with promising phase 1 results, and CTX112, which targets various cancers and autoimmune disorders, both of which could contribute to stock price increases [6][8] Group 2: Vertex Pharmaceuticals - Vertex Pharmaceuticals has faced challenges this year, primarily due to its reliance on its cystic fibrosis (CF) treatments, but these continue to generate steady revenue [10] - In Q3, Vertex reported an 11% year-over-year revenue increase to $3.08 billion and a 4.7% increase in net earnings per share to $4.20, indicating strong performance in its core area [11] - The company is advancing new therapies, including zimislecel for Type 1 diabetes and candidates targeting kidney diseases, with regulatory submissions planned for next year [13][14]

Core Insights - CRISPR Therapeutics AG reported a narrower-than-expected loss in Q3 2025, with a loss of $1.17 per share compared to the Zacks Consensus Estimate of a loss of $1.32 [2] - Total revenues for the quarter were $0.9 million, significantly missing the consensus estimate of $6.7 million, although this was an increase from $0.6 million in the same quarter last year [3] Financial Performance - Research and development (R&D) expenses decreased by 28% year-over-year to $58.9 million, attributed to reduced manufacturing and employee-related costs [4] - General and administrative expenses fell by 3% year-over-year to $16.9 million [4] - Net collaboration expenses rose to $57.1 million from $11.2 million in the year-ago period, primarily due to reaching a deferral limit on costs related to the Casgevy program [5] Market Sentiment - There has been an upward trend in estimates for CRISPR Therapeutics, with the consensus estimate shifting by 6.45% in the past month [6] - The stock currently holds a Zacks Rank of 3 (Hold), indicating expectations for an in-line return in the coming months [8] Industry Comparison - CRISPR Therapeutics operates within the Zacks Medical - Biomedical and Genetics industry, where Acadia Pharmaceuticals has seen a 13.4% gain over the past month [9] - Acadia reported revenues of $278.63 million for the last quarter, reflecting a year-over-year increase of 11.3% [10]

Core Insights - The biotech industry presents significant growth potential for investors, particularly through companies like CRISPR Therapeutics and Iovance Biotherapeutics, which have substantial upside based on Wall Street price targets [2][16]. CRISPR Therapeutics - CRISPR Therapeutics specializes in gene-editing medicines using the CRISPR technique and has received regulatory approval for its product Casgevy, which targets blood-related disorders [4][16]. - The company is developing CTX310, a therapy aimed at lowering LDL cholesterol and triglycerides, with a potential market of 40 million patients in the U.S. alone [7][8]. - CTX310 is an in vivo therapy, which simplifies administration compared to Casgevy, potentially leading to significant share price increases if clinical progress continues [8][17]. - The company has a meaningful addressable market for Casgevy, estimated at 60,000 patients, with a high price point of $2.2 million in the U.S. [16][17]. Iovance Biotherapeutics - Iovance Biotherapeutics has an approved therapy, Amtagvi, for advanced melanoma, generating $67.5 million in revenue, reflecting a 13% year-over-year increase [9][13]. - The company estimates that around 8,000 patients die from melanoma annually in the U.S., indicating a significant need for effective treatments [10]. - Iovance is pursuing international approvals for Amtagvi, having already succeeded in Canada, and is targeting markets in Australia, the UK, and the EU [11]. - Despite the potential for label expansions, the complex administration process of Amtagvi limits its market potential, and the company lacks a strong commercial partner [14][15].

Core Insights - Crispr Therapeutics AG (CRSP) is a market leader in transformative therapies utilizing CRISPR/Cas9 technology, having received FDA approval in December 2023 and EMA approval in February 2024 for its product Casgevy [1] Company Overview - Crispr Therapeutics AG was founded in 2013 and is headquartered in Zug, Switzerland [1] Investment Perspective - The investment philosophy emphasizes the importance of compounding, dividend reinvesting, and patient investing through various market conditions to achieve significant rewards [1] - The strategy includes a mix of steady accumulation of high-quality assets along with high-risk/high-reward opportunities and transformative technologies [1]

Core Viewpoint - The article discusses the rising trend of high-priced gene therapies, particularly focusing on Novartis's newly approved gene therapy Itvisma for spinal muscular atrophy, priced at $2.59 million, which highlights the challenges of commercialization and reimbursement in the gene therapy market [3][6]. Pricing and Market Dynamics - Novartis's Itvisma is priced at $2.59 million, surpassing its earlier product Zolgensma, which was priced at $2.125 million [3][4]. - The global list of the most expensive drugs includes several gene therapies, with the top position held by Kyowa Kirin's Lenmeldy at $4.25 million, followed by CSL's Hemgenix at $3.5 million [4][5]. - The article notes that despite the high prices, many gene therapies face commercialization challenges, as seen with Bluebird Bio's products, which have not achieved significant sales despite their high price tags [5][6]. Sales Performance and Market Challenges - Zolgensma generated $1.2 billion in sales in 2024, maintaining its performance from the previous year, while Bluebird Bio's Lyfgenia only achieved $10 million in sales in Q3 2024 [6][7]. - The article emphasizes the disparity between the high prices of gene therapies and their actual market performance, indicating a potential "value without market" scenario [5][6]. Future Outlook and Market Growth - The global gene therapy market is projected to grow from $9 billion in 2024 to $11.5 billion in 2025, with an expected compound annual growth rate of 27.6% [7]. - The article suggests that a balance between innovation and accessibility is crucial for the future of gene therapies, with a collaborative approach needed from payers, regulators, and pharmaceutical companies [7][8].

Core Insights - CRISPR Therapeutics AG (NASDAQ:CRSP) is highlighted as one of the top 10 stocks to buy from Cathie Wood's ARK Investment portfolio, representing approximately 3.8% of the portfolio with a value of around $634 million [1] - The stock has a moderately positive outlook, with 60% of analysts rating it as Buy or equivalent, and a consensus 1-year median price target of $80, indicating nearly a 50% upside potential [2] - Citi analyst Yigal Nochomovitz maintains a Buy rating on CRISPR but has adjusted the price target from $87 to $77 [3] Financial Performance - In Q3 2025, CRISPR reported a net loss of $106.4 million, an increase from $85.9 million in Q3 2024, attributed to higher collaboration expenses [5] - The company maintains a strong balance sheet with cash and cash equivalents totaling $1.94 billion as of the end of September [5] Clinical Developments - CRISPR announced positive phase 1 clinical data for CTX310, a gene-editing therapy targeting the ANGPTL3 gene, which aims to lower triglycerides and LDL cholesterol in patients with severe dyslipidemia [4] - The Chief Medical Officer emphasized the significance of the trial results, marking a milestone for in vivo gene editing and supporting the advancement of CTX310 and the broader cardiovascular gene-editing portfolio [5]

Core Insights - CRISPR Therapeutics has begun generating revenue from its first product, a blood disorder treatment called Casgevy, which has been approved by regulators [7][10] - Cathie Wood, CEO of Ark Invest, has been consistently increasing her holdings in CRISPR Therapeutics, indicating strong confidence in the company's future growth potential [5][6] - The stock has experienced significant declines, dropping 17% since the approval of Casgevy and over 55% in the past five years, presenting a potential buying opportunity for growth investors [12][13] Company Overview - CRISPR Therapeutics specializes in gene editing technology, which has shown promise in correcting faulty genes responsible for diseases [8] - The company has a market capitalization of $5 billion and its stock is currently priced at $53.47 [11] - CRISPR Therapeutics has a gross margin of -36522.94%, indicating challenges in profitability [11] Product and Revenue Generation - The approval of Casgevy is a significant milestone, demonstrating the effectiveness of CRISPR's technology and paving the way for future product approvals [7][8] - Vertex Pharmaceuticals, a partner of CRISPR, expects Casgevy to generate over $100 million in revenue this year, with CRISPR receiving 40% of the profits [10] - The rollout of gene editing treatments is complex and time-consuming, which means revenue generation will take time [10] Clinical Trials and Future Prospects - CRISPR Therapeutics is advancing other candidates through clinical trials, including CTX310, which has shown positive results in lowering triglycerides and LDL levels [11] - The company is exploring applications of its technology in various fields, including oncology and cardiovascular health [11] - Despite recent stock price declines, the approval of Casgevy and positive trial results suggest that CRISPR Therapeutics has significant growth potential ahead [12][13]

Core Insights - CRISPR Therapeutics AG (NASDAQ:CRSP) is identified as a top short squeeze stock, with Citizens maintaining a Market Outperform rating and an $86 price target as of November 11 [1] - Positive findings from CRISPR's presentation at the American Heart Association regarding CTX310, which targets ANGPTL3 for cholesterol-related issues, have contributed to optimism [1][2] - The company has several upcoming catalysts, including updates on in-vivo cardiovascular projects and a pediatric review for Casgevy scheduled for 2025 [2] Financial Performance - In the third quarter, Casgevy sales were reported at $17 million, significantly below the consensus estimate of $41 million, with infusions decreasing from 16 in the second quarter to 10 [3] - Despite the sales shortfall, CRISPR remains optimistic about the Casgevy launch, noting an increase in cell collection numbers from 25 in the second quarter to 45 [3] Company Overview - CRISPR Therapeutics AG is recognized as a leader in gene-editing technology, utilizing its proprietary gene sequencing platform to develop precise treatments for diseases requiring DNA modification [4]

Core Insights - CRISPR Therapeutics AG (NASDAQ:CRSP) is identified as one of the most oversold biotech stocks, with Oppenheimer reaffirming an Outperform rating and a $95 price target following the company's Q3 financial results [1] - The company reported a lower-than-expected loss of $1.17 per share, compared to the anticipated loss of $1.26 per share, attributed to reduced R&D spending of $59 million versus the expected $88 million [1] Financial Performance - The collaboration expenses for the gene treatment Casgevy amounted to $57 million for the quarter, indicating a slow launch, while partner Vertex noted an increase in momentum for its debut [2] - The advancements in CRISPR's in vivo initiatives were highlighted, particularly the findings from the Phase 1 study of CTX310 presented at the AHA meeting and published in the New England Journal of Medicine [2] Technological Advancements - CRISPR's SyNTase editing technology, showcased in the CTX460 data, is noted to have significant potential, enhancing the company's existing strategies and in vivo initiatives [3] - The company is recognized as a leader in gene-editing technology, utilizing its proprietary gene sequencing platform to develop precise treatments for diseases requiring DNA modification [3]