Core Insights - Regeneron Pharmaceuticals reported strong financial performance in 2025, driven by four blockbuster medicines and a promising late-stage clinical portfolio [2][3] - The company achieved significant label expansions and new approvals for its key products, including EYLEA HD and Dupixent, enhancing their commercial potential [2][4] Financial Highlights - Total revenues for Q4 2025 were $3,884 million, a 3% increase from Q4 2024, while full year revenues reached $14,343 million, up 1% from 2024 [3][14] - GAAP net income for Q4 2025 was $845 million, down 8% from Q4 2024, with a full year GAAP net income of $4,505 million, an increase of 2% [3][14] - Non-GAAP net income for Q4 2025 was $1,249 million, a decrease of 10% from Q4 2024, while full year non-GAAP net income was $4,888 million, down 8% [3][14] Business Highlights - Dupixent global net sales increased by 34% in Q4 2025 to $4.9 billion, with full year sales rising 26% to $17.8 billion [4][14] - EYLEA HD U.S. net sales surged 66% in Q4 2025 to $506 million, with full year sales increasing 36% to $1.6 billion [4][14] - Libtayo received additional approvals and is now the leading immunotherapy for non-melanoma skin cancers [2][4] Pipeline Progress - Regeneron has approximately 45 product candidates in clinical development, with several key updates expected in 2026 [4][10] - Upcoming milestones include FDA decisions for EYLEA HD pre-filled syringe and Dupixent's regulatory submissions for new indications [13][28] Capital Allocation - The company repurchased $671 million of its common stock in Q4 2025 and $3.5 billion for the full year, with $1.5 billion remaining for future repurchases [26] - A cash dividend of $0.94 per share was declared, payable on March 5, 2026 [27] 2026 Financial Guidance - Regeneron projects GAAP R&D expenses between $6.450 billion and $6.680 billion for 2026, with non-GAAP R&D expenses expected to be between $5.900 billion and $6.100 billion [28][29] - The company anticipates a GAAP effective tax rate of 12% to 14% for 2026 [28]

Regeneron Pharmaceuticals, Inc. (NASDAQ:REGN) will release earnings results for its fourth quarter, before the opening bell on Friday, Jan. 30.Analysts expect the Tarrytown, New York-based company to report quarterly earnings at $10.74 per share, down from $12.07 per share in the year-ago period. The consensus estimate for Regeneron Pharmaceuticals' quarterly revenue is $3.79 billion, versus $3.79 billion a year earlier, according to data from Benzinga Pro.On Dec. 1, Regeneron Pharmaceuticals and Tessera Th ...

Earnings Results - Regeneron Pharmaceuticals is set to release its fourth-quarter earnings results on January 30, with analysts expecting earnings of $10.74 per share, a decrease from $12.07 per share in the same period last year [1] - The consensus estimate for quarterly revenue is $3.79 billion, unchanged from the previous year [1] Collaboration Announcement - On December 1, Regeneron Pharmaceuticals announced a global collaboration with Tessera Therapeutics to develop and commercialize TSRA-196 [2] - Following the announcement, Regeneron Pharmaceuticals shares experienced a slight decline of 0.2%, closing at $749.44 [2] Analyst Ratings - Benzinga provides access to the latest analyst ratings for Regeneron Pharmaceuticals, allowing readers to sort by various criteria such as stock ticker and rating change [2]

We recently compiled a list of the 20 Most Profitable Stocks of the Last 20 Years. Regeneron Pharmaceuticals, Inc. is among the most profitable stocks. TheFly reported on January 22 that Evercore ISI increased its price target for REGN to $875 from $750 and maintained an Outperform rating on the stock. The firm expressed confidence in REGN’s updated outlook and recent pricing actions. Evercore ISI identified Dupixent and Eylea HD as key players in the company’s growth and noted that both products are well ...

Core Viewpoint - Regeneron Pharmaceuticals is a leading biotechnology company focused on developing innovative medicines for serious diseases, competing with major players like Amgen and Biogen [1] Financial Performance - Regeneron is set to release its quarterly earnings on January 30, 2026, with an estimated EPS of $10.56 and revenue of approximately $3.78 billion, while the Zacks Consensus Estimate projects revenues at $3.82 billion [2] - Historically, Regeneron has exceeded earnings estimates in three of the last four quarters, with an average surprise of 21.81% [2] Product Focus - The upcoming earnings report will emphasize profits from the asthma drug Dupixent and sales of Eylea HD, with Eylea's legacy sales declining due to competition, but Eylea HD expected to boost overall franchise revenues [3] - Strong demand for Dupixent across multiple indications is anticipated to drive solid profit growth, offsetting the decline in Eylea sales [3] Stock Performance - Regeneron's stock has increased over 16% since the last analysis, reinforcing a Buy rating, although it is still trading below its all-time high of approximately $1,200 reached in August 2024 [4] - The earnings report could potentially drive the stock price higher if results exceed expectations, while a miss might lead to a decline in stock value [4] Valuation Metrics - Regeneron has a price-to-earnings (P/E) ratio of approximately 17, indicating investors are willing to pay $17 for every $1 of earnings [5] - The company's price-to-sales ratio stands at about 5.44, and the enterprise value to sales ratio is roughly 5.46, indicating consistent valuation metrics [5] - Regeneron demonstrates a solid financial position with a low debt-to-equity ratio of 0.087 and a strong current ratio of 4.06 [5][6]

Core Insights - Investors are focusing on profits from the asthma drug Dupixent and sales of Eylea HD as Regeneron Pharmaceuticals prepares to report its fourth-quarter 2025 results on January 30, 2026, with revenue estimates at $3.82 billion and earnings at $10.56 per share [1] Earnings Performance - Regeneron has a history of earnings surprises, beating estimates in three of the last four quarters with an average surprise of 21.81%, including a 25.32% beat in the last reported quarter [2] Earnings Prediction - The earnings model predicts a likely earnings beat for Regeneron, supported by a positive Earnings ESP of +0.82% and a Zacks Rank of 1 (Strong Buy) [3][4] Product Sales Overview - Eylea, a key revenue driver, has faced sales pressure due to competition from Vabysmo, with preliminary sales of $577 million in the U.S. for Q4 [5][6] - Eylea HD, a higher dose version, has seen strong initial uptake with sales of $506 million in the U.S. for the quarter, following FDA approval for new dosing options [7][8] Dupixent Performance - Dupixent is expected to show solid growth in Q4, driven by strong demand across multiple indications, likely offsetting the decline in Eylea sales [10] Diversification Strategy - Regeneron is working to diversify its revenue base beyond Eylea, focusing on building its oncology franchise, which includes Libtayo and the newly approved Lynozyfic [11] - Libtayo's sales growth has been bolstered by recent label expansions, with current sales estimates at $482 million [12] Share Repurchase Program - A decrease in outstanding shares due to a $3.0 billion share repurchase program is expected to positively impact the bottom line, with $2.156 billion remaining for repurchases as of September 30, 2025 [15] Stock Performance - Regeneron's shares have increased by 12.2% over the past year, compared to the industry's growth of 17.1% [16]

Core Insights - Chautauqua Capital Management's fourth-quarter 2025 investor letter highlights a strong performance in global equities, with international markets outperforming U.S. equities significantly, aided by a weaker dollar and improving trade conditions [1] - The Baird Chautauqua International Growth Fund returned +0.11% in Q4 2025, lagging behind the MSCI ACWI ex-U.S. Index's +5.05%, while the Global Growth Fund gained +4.18%, outperforming its MSCI ACWI Index® ND's +3.29% [1] - The fund remains focused on high-quality businesses with strong cash flows and balance sheets, despite near-term headwinds from sector rotations and profit-taking in Greater China [1] Company-Specific Insights - Regeneron Pharmaceuticals, Inc. (NASDAQ:REGN) is highlighted as a biotechnology leader with a focus on innovative medicines for serious diseases, reporting a one-month return of approximately -0.30% and shares remaining about 12.42% above their 52-week high [2] - As of January 26, 2026, Regeneron's stock closed at approximately $762.65 per share, with a market capitalization of about $81.779 billion [2] - Regeneron reported strong Q3 2025 results, with top- and bottom-line beats driven by Dupixent and Eylea HD, and expects resolution of manufacturing issues in 2026 along with important pipeline data readouts [3] - Regeneron is not among the 30 Most Popular Stocks Among Hedge Funds, with 78 hedge fund portfolios holding the stock at the end of Q3, an increase from 73 in the previous quarter [3]

Core Viewpoint - The global GLP-1 market is shifting, with multinational pharmaceutical companies increasingly focusing on Chinese biopharmaceutical assets, a trend expected to peak in 2025 and be confirmed in early 2026 [5] Group 1: Market Dynamics - The competition in the weight loss and metabolic disease market is evolving from single product competition to a comprehensive contest involving multiple mechanisms, indications, and long-term medication [5] - Multinational pharmaceutical companies are experiencing anxiety regarding pipeline breadth and technological reserves, with China emerging as a key source for supplementing GLP-1 pipelines [5] - Over the past decade, the role of Chinese innovative drug companies has shifted from introducing overseas technology to exporting self-developed assets [5] Group 2: Asset Development - Chinese companies have accumulated a number of candidates in the GLP-1 field, particularly in dual-target, triple-target, and oral formulations, with several in Phase II and III [5] - These assets are characterized by preliminary validation of scientific pathways and identifiable clinical risks, making them valuable for multinational companies to quickly fill their pipelines through licensing or acquisition [5] Group 3: Transaction Highlights - Novo Nordisk made a significant move by securing rights to a triple-target agonist, UBT251, with a payment structure of $200 million upfront and up to $1.8 billion in milestone payments, reflecting a strategic choice to rebuild its next-generation weight loss product lineup [7] - Regeneron entered a licensing agreement with Hansoh Pharma worth over $2 billion for a GLP-1/GIP dual-target agonist in Phase III, aiming to strengthen its position in the metabolic disease field [7] - Pfizer, after terminating two late-stage oral GLP-1 candidates due to safety issues, acquired Metsera for nearly $10 billion and entered a licensing agreement with YaoPharma for an early-stage oral GLP-1 candidate, demonstrating a cautious approach to re-entering the oral weight loss drug market [7] Group 4: Strategic Implications - These transactions signal that multinational pharmaceutical companies are preparing for the second phase of competition in the GLP-1 market, focusing on efficacy limits, medication convenience, long-term safety, and combination therapy potential [8] - The shift indicates a structural adjustment in the global pharmaceutical industry, with China transitioning from merely a clinical trial and production base to a significant technology supplier in key therapeutic areas [8]

Group 1 - The pharmaceutical industry is currently at a crucial juncture, with significant earnings reporting scheduled for January 30th following the J.P. Morgan Healthcare Conference in mid-January [1] - The Haggerston BioHealth investing group, led by a biotech consultant with over 5 years of experience, provides detailed reports on over 1,000 companies in the biotech, healthcare, and pharma sectors [2] - The group offers insights into catalysts for investment decisions, including buy and sell ratings, product sales forecasts, and integrated financial statements [2]

Core Viewpoint - The comparison between Regeneron (REGN) and Illumina (ILMN) indicates that REGN presents a better value opportunity for investors at this time due to its stronger earnings outlook and more attractive valuation metrics [1][3][7]. Valuation Metrics - REGN has a Zacks Rank of 1 (Strong Buy), while ILMN has a Zacks Rank of 3 (Hold), suggesting a stronger improvement in REGN's earnings outlook [3]. - REGN's forward P/E ratio is 17.17, significantly lower than ILMN's forward P/E of 30.42, indicating that REGN may be undervalued relative to ILMN [5]. - The PEG ratio for REGN is 1.56, compared to ILMN's PEG ratio of 2.56, further supporting REGN's valuation attractiveness [5]. - REGN's P/B ratio stands at 2.56, while ILMN's P/B ratio is much higher at 9.88, reinforcing the notion that REGN is a better value stock [6]. - REGN has been assigned a Value grade of B, whereas ILMN has a Value grade of C, highlighting the relative valuation strength of REGN [6]. Investment Conclusion - Given the stronger estimate revision activity and more favorable valuation metrics, value investors are likely to favor REGN over ILMN as the superior investment option at this time [7].