Financial Data and Key Metrics Changes - Illumina reported Q4 2025 revenue of $1.16 billion, a 5% increase year-over-year on a reported basis and 4% on a constant currency basis [20][22] - Non-GAAP EPS for Q4 was $1.35, reflecting a 42% year-over-year growth [26] - Non-GAAP operating margin expanded to 23.7%, up 400 basis points year-over-year [25] Business Line Data and Key Metrics Changes - Clinical consumables revenue grew 20% in Q4 2025, excluding China, driven by increased adoption of sequencing-based diagnostic tests [5][8] - Sequencing consumables revenue reached $755 million, an 8% increase year-over-year [22] - Research and applied markets consumable sales were roughly flat year-over-year, indicating a stabilization compared to previous quarters [22] Market Data and Key Metrics Changes - Greater China revenue was $55 million, down $25 million from Q4 2024, reflecting ongoing export restrictions [22] - Clinical market growth outside of China was 20%, driven by broader adoption of NGS-based testing [22] - Total sequencing GB output grew over 30% year-over-year, primarily from clinical applications [24] Company Strategy and Development Direction - Illumina's strategy focuses on three pillars: core sequencing, scaling multi-omics, and expanding service data and software capabilities [10][12] - The acquisition of SomaLogic is expected to enhance Illumina's position in the proteomics market, integrating capabilities for deeper biological insights [11][12] - The company aims to introduce new technologies, including spatial transcriptomics and constellation map read technology, in the first half of 2026 [13] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the momentum built in 2025, expecting organic revenue growth of 2%-4% in 2026, excluding China [17][30] - Clinical consumables are projected to grow double-digit to mid-teens in 2026, while research consumables are expected to decline mid- to high-single digits [30][31] - Management highlighted the importance of adapting to the evolving funding environment in the research sector [44] Other Important Information - The company returned approximately $740 million to shareholders through share repurchases in 2025 [7] - Illumina ended Q4 with approximately $1.63 billion in cash and cash equivalents [28] - The company plans to continue share repurchases opportunistically, with $643 million remaining on its authorization [27] Q&A Session Summary Question: Operating margin guidance and capital deployment - Management confirmed that the guidance includes an assumption of ending the year at 26%-27% operating margin and remains committed to long-term margin targets despite the SomaLogic acquisition [36][38] Question: Clinical performance guidance for 2026 - Management explained that the guidance reflects a cautious approach, considering uncertainties in the research environment, but remains optimistic about clinical growth momentum [42][45] Question: Instrumentation split between research and clinical - Management indicated that over 60% of Q4 instrument placements were clinical, with expectations for this trend to continue into 2026 [50][52] Question: Growth drivers in oncology and genetic applications - Management noted that oncology remains the main growth driver, with increasing use of genetic profiling for various applications [66] Question: Competitive landscape and pricing strategies - Management expressed confidence in Illumina's competitive position and highlighted ongoing discussions with customers regarding pricing and workflow efficiencies [74][76]

Financial Data and Key Metrics Changes - Illumina reported Q4 revenue of $1.16 billion, up 5% year-over-year on a reported basis and 4% on a constant currency basis [20][22] - Non-GAAP EPS for Q4 was $1.35, growing approximately 42% year-over-year, exceeding guidance [26] - Non-GAAP operating margin was 23.7% in Q4, expanding 400 basis points year-over-year [25] Business Line Data and Key Metrics Changes - Clinical consumables revenue grew 20% year-over-year in Q4, driven by increased adoption of sequencing-based diagnostic tests [5][8] - Sequencing consumables revenue was $755 million, up 8% year-over-year, with 11% growth excluding China [22] - Research and applied markets consumable sales were roughly flat year-over-year, reflecting ongoing uncertainty in the funding environment [22] Market Data and Key Metrics Changes - Greater China revenue was $55 million, representing a $25 million decline from Q4 of 2024 [22] - Clinical market maintained momentum, growing 20% outside of China, driven by broader adoption of NGS-based testing [22] - Total sequencing GB output grew at a rate of more than 30% year-over-year, primarily from clinical customers [24] Company Strategy and Development Direction - Illumina's strategy focuses on three pillars: core sequencing, scaling multi-omics, and expanding service data and software capabilities [10][13] - The acquisition of SomaLogic is expected to enhance Illumina's position in the proteomics market, integrating capabilities for deeper biological insights [12] - The company aims to introduce new technologies, including spatial transcriptomics and constellation map read technology, in 2026 [13] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the momentum built in 2025, expecting organic revenue growth of 2%-4% in 2026, excluding China [17][30] - Clinical consumables are projected to grow double-digit to mid-teens in 2026, while research consumables are expected to decline mid-to-high single digits [30][31] - Management highlighted the importance of adapting to the evolving market dynamics and customer needs, particularly in the clinical space [16][70] Other Important Information - Illumina returned approximately $740 million to shareholders through share repurchases in 2025 [7] - The company ended Q4 with approximately $1.63 billion in cash and cash equivalents [28] - The acquisition of SomaLogic was completed for an upfront payment of $350 million, with potential royalties and milestone payments [27] Q&A Session Summary Question: Operating margin guidance and capital deployment - Management confirmed that the guidance includes an assumption of ending the year at 26%-27% operating margin and discussed capital deployment priorities [36][38] Question: Clinical performance guidance for 2026 - Management explained that the guidance reflects a cautious approach, considering uncertainties in the research environment, but remains optimistic about clinical growth [42][45] Question: Instrumentation split between research and clinical - Management indicated that over 60% of NovaSeq X placements were to clinical customers, with expectations for this trend to continue [50][52] Question: Growth drivers in oncology and genetic applications - Management noted that oncology remains the main growth driver, with increasing use of genetic profiling for various diseases [66] Question: Competitive landscape and pricing strategies - Management expressed confidence in Illumina's competitive position and the ability to address market segments with different pricing strategies [74][76] Question: China market assumptions and BioInsight monetization - Management discussed ongoing conversations with Chinese regulators and the potential for growth in the BioInsight business, emphasizing its early-stage momentum [80][81]

Financial Data and Key Metrics Changes - In Q4 2025, Illumina's revenue reached $1.16 billion, reflecting a 5% year-over-year increase on a reported basis and a 4% increase on a constant currency basis [18][19] - Non-GAAP EPS for Q4 was $1.35, growing approximately 42% year-over-year, exceeding guidance [24] - Non-GAAP operating margin was 23.7% in Q4, expanding 400 basis points year-over-year [23] Business Line Data and Key Metrics Changes - Clinical consumables revenue grew 20% year-over-year in Q4, driven by increased adoption of sequencing-based diagnostic tests [4][19] - Sequencing consumables revenue was $755 million, up 8% year-over-year, with a notable 11% increase excluding China [19] - Sequencing instruments revenue was approximately flat year-over-year at $154 million, with strong placements of NovaSeq X [22] Market Data and Key Metrics Changes - Greater China revenue was $55 million, down $25 million from Q4 2024, reflecting export restrictions [19] - Clinical market outside China grew 20%, driven by broader adoption of NGS-based testing [19] - Research and applied markets saw consumable sales remain roughly flat year-over-year, indicating ongoing uncertainty in the funding environment [20] Company Strategy and Development Direction - Illumina's strategy focuses on three pillars: core sequencing, scaling multi-omics, and expanding service data and software capabilities [9][12] - The acquisition of SomaLogic is expected to enhance Illumina's position in the proteomics market, integrating capabilities to accelerate innovation [10][11] - The company aims to introduce new technologies, including spatial transcriptomics and constellation map read technology, in the first half of 2026 [12] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the momentum built in the second half of 2025, expecting organic revenue growth of 2%-4% in 2026, excluding China [15][27] - Clinical consumables are projected to grow double-digit to mid-teens in 2026, while research consumables are expected to decline mid- to high-single digits [15][29] - Management highlighted the importance of adapting to evolving market dynamics and customer needs, particularly in the context of multi-omics [14][78] Other Important Information - The company returned approximately $740 million to shareholders through share repurchases in 2025 [5] - Illumina ended Q4 with approximately $1.63 billion in cash and cash equivalents, maintaining a strong balance sheet [25] - The company plans to change geographical reporting segments starting in Q1 2026 to better align with its commercial structure [31] Q&A Session Summary Question: Operating margin guidance and capital deployment - Management confirmed that the guidance includes an assumption of ending the year at 26%-27% operating margin and remains committed to long-term margin targets despite the SomaLogic acquisition [33][36] Question: Clinical performance guidance for 2026 - Management explained that the guidance reflects continued momentum in clinical growth, with expectations for mid-teens growth, while acknowledging challenges in the research environment [40][42] Question: Instrumentation split between research and clinical - Over 60% of Q4 instrument placements were clinical, with expectations for this trend to continue into 2026 [46][48] Question: Growth drivers in oncology and genetic applications - Oncology is expected to remain the main growth driver, with significant uptake in genetic profiling for various diseases [62][64] Question: BioInsight monetization strategy - Management outlined plans for monetizing BioInsight through specialized data and subscription-based models, indicating a multi-year opportunity [78][79]

Q4 2025 Earnings Presentation February 5, 2026 © 2026 Illumina, Inc. All rights reserved. Cautionary Notes Year-over-year (YoY) denotes a comparison against the same quarter of the previous fiscal year, while quarter-over-quarter (QoQ) or "sequential" denotes a comparison against the previous fiscal quarter. In addition, all references to China refer to our Greater China Region, which also includes Taiwan and Hong Kong. © 2026 Illumina, Inc. All rights reserved. 2 RGB: 229, 96, 0 RGB: 228, 189, 255 RGB: 255 ...

Consolidated Balance Sheets(In millions)December 28,2025December 29,2024ASSETS(unaudited)Current assets:Cash and cash equivalents$ 1,418$ 1,127Short-term investments21593Accounts receivable, net854735Inventory, net564547Prepaid expenses and other current assets238244Total current assets3,2892,746Property and equipment, net759815Operating lease right-of-use assets370419Goodwill1,1131,113Intangible assets, net210295Deferred tax assets, net454567Other assets449348Total assets$ 6,644$ 6,303LIABILITIES AND STOCK ...

此次整合标志着多组学研究新时代的开启，生物医学研究有望迎来新的发展机遇。 摘要 ： 基因测序巨头斥资3.5亿美元将蛋白质组学技术领导者纳入麾下，旨在为客户提供更全面的多 组学解决方案。 特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我 们的推送。 美国加利福尼亚州圣迭戈——2026年1月30日，因美纳公司宣布已完成对蛋白质组学技术领 域领先企业SomaLogic的收购。此次交易总价值达3.5亿美元，另加高达7500万美元的绩效 里程碑款项。 这 一 收 购 标 志 着 因 美 纳 在 实 施 2024 年 提 出 的 多 组 学 战 略 过 程 中 取 得 重 要 进 展 。 通 过 整 合 SomaLogic高度差异化的蛋白质组学技术，因美纳将增强在基因组学与蛋白质组学领域提供 可扩展洞察的能力。 因美纳首席执行官Jacob Thay sen表示："欢迎SomaLogic团队加入因美纳，这是我们落实 2024年制定的多组学战略 的重要里程碑。" 此前，在2025年6月宣布收购协议时，因美纳曾表示预计该业务将在2027年实现非GAAP的 经营收入盈利。 ...

Group 1 - The Central Political Bureau of the Communist Party of China emphasized the need for strategic planning in future industries, highlighting the acceleration of technological revolution and industrial transformation [1] - Xi Jinping's article in "Qiushi" magazine outlines the characteristics of a financial power, including a strong currency, effective central bank, robust financial institutions, and a well-regulated financial environment [2] - China's official manufacturing PMI for January is reported at 49.3%, indicating a contraction, while the non-manufacturing PMI is at 49.4%, reflecting a decline in business activity [3] Group 2 - A significant number of A-share listed companies are disclosing their 2025 performance, revealing a polarized performance across industries, with some companies achieving substantial profit growth while others, like real estate and photovoltaic sectors, face challenges [6] - The financial market remains active, with major brokerage firms like CITIC Securities and Guotai Junan expected to maintain strong performance, with CITIC Securities projecting a net profit exceeding 30 billion yuan for 2025 [6] - Public funds are increasing their allocation to non-bank financial sectors, with insurance companies like Ping An and China Pacific receiving significant attention from investors [7] Group 3 - The Ministry of Finance and the State Taxation Administration clarified the calculation of sales revenue for VAT taxable transactions involving financial products, impacting how financial institutions report earnings [4] - New regulations aimed at encouraging foreign investment and regulating competition are set to take effect in February, which may influence market dynamics [5] - The Chongqing Liangjiang New Area is set to deepen cooperation with the Tianfu New Area, focusing on economic development and industrial collaboration [6] Group 4 - The total sales of the top 100 real estate companies in January amounted to 190.52 billion yuan, showing a year-on-year decline of 18.9%, indicating ongoing challenges in the real estate market [8] - The AI computing power infrastructure is experiencing rapid growth, with the domestic transformer market expected to grow over 20% in 2025, driven by AI-related projects [9] - The price of photovoltaic components has increased due to rising silver prices, affecting downstream manufacturers and leading to price adjustments in the market [9]

Group 1 - The Central Political Bureau of the Communist Party of China emphasized the need for strategic planning in future industries, highlighting the acceleration of technological and industrial transformation [3] - Xi Jinping's article in "Qiushi" magazine outlines the characteristics of a financial power, including a strong currency, effective central bank, robust financial institutions, and a well-regulated financial environment [3] - China's official manufacturing PMI for January is reported at 49.3%, indicating a contraction, while the non-manufacturing PMI is at 49.4%, reflecting a decline in business activity [4] Group 2 - The Ministry of Finance and the State Taxation Administration clarified the calculation of sales revenue for VAT taxable transactions involving financial products [5] - The GDP data for 2025 shows that Tibet leads the country with a growth rate of 7.0%, driven by major infrastructure projects [7] - A new set of regulations will take effect in February, including measures to encourage foreign investment and regulate competition [7] Group 3 - A-share companies are entering a busy earnings disclosure period for 2025, with over 70 companies already reporting, indicating a polarized performance across industries [8] - The performance of listed brokerages is under scrutiny, with major firms like CITIC Securities and Guotai Junan expected to maintain strong market positions [8] - Public funds have increased their allocation to non-bank financial sectors, particularly insurance stocks, indicating a shift in investment strategy [9] Group 4 - The National Financial Regulatory Administration has intensified scrutiny of banks' credit business violations, with penalties focusing on credit-related infractions [10] - The China Automobile Dealers Association reported a January inventory warning index of 59.4%, indicating a slight increase in inventory levels [10] - The real estate sector continues to face challenges, with the top 100 real estate companies reporting a sales total of 190.5 billion yuan in January, a year-on-year decline of 18.9% [10] Group 5 - The Beijing Economic-Technological Development Area is advancing its plan to build an AI city, focusing on integrating AI across various sectors [11] - The domestic transformer market is expected to grow over 20% in 2025, driven by AI computing and high-voltage products [11] - The price of photovoltaic components has increased due to rising silver prices, impacting downstream manufacturers [11] Group 6 - The U.S. Senate passed a $1.2 trillion funding bill, but the House of Representatives is expected to delay voting, leading to a partial government shutdown [16] - The SEC is operating with limited staff due to the funding lapse, affecting its regulatory functions [16] - NASA's Perseverance rover successfully completed a route planning task using AI, marking a significant milestone in autonomous operations [16]

Core Insights - Illumina has completed the acquisition of SomaLogic, enhancing its capabilities in proteomics and multiomics, which will facilitate faster drug discovery and improve healthcare outcomes [1][2][5] Group 1: Acquisition Details - The acquisition was finalized for $350 million in cash, with potential additional payments of up to $75 million based on performance milestones [6] - This acquisition builds on a prior partnership that began in late 2021, aimed at integrating SomaLogic's technology with Illumina's high-throughput NGS platforms [5] Group 2: Strategic Implications - The combination of SomaLogic's proteomics technology with Illumina's existing innovations is expected to provide scalable insights across genomics and proteomics, enhancing customer outcomes [2][3] - Illumina aims to leverage this acquisition to strengthen its position in the growing proteomics market, thereby complementing its high-throughput sequencing business [3] Group 3: Product Integration and Support - Illumina will ensure continuity of products and services as SomaLogic's portfolio is integrated into its offerings, maintaining support for existing customers [4][5] - The integration will allow customers to generate rich multiomic datasets, utilizing a combination of SomaLogic's and Illumina's technologies [2][5]

Core Viewpoint - Standard BioTools Inc. reported its second quarter 2025 financial results, highlighting a strategic sale of SomaLogic to Illumina, which is expected to unlock up to $425 million in cash and enhance the company's financial position towards profitability by 2026 [3][6][10]. Financial Performance - Revenue for the second quarter of 2025 was $21.8 million, a decrease of 3% year-over-year, while total revenue for the first half of 2025 was $42 million, down 5% year-over-year [4][7]. - Consumables revenue increased by 18% year-over-year to $10.5 million in the second quarter, although total consumables revenue for the first half decreased by 3% to $18.6 million [7][21]. - Instruments revenue fell by 26% year-over-year to $5.2 million in the second quarter, with a slight decrease of 1% to $11.9 million for the first half [13][21]. - Services revenue was $6.1 million in the second quarter, down 8% year-over-year, and $11.5 million for the first half, down 11% year-over-year [13][21]. Gross Margin and Operating Expenses - Gross margin for the second quarter of 2025 was approximately 48.8%, compared to 46.1% in the same quarter of 2024, while non-GAAP gross margin was 54.1%, up from 48.6% [13][22]. - Operating expenses decreased by 11% year-over-year to $36.3 million in the second quarter, with non-GAAP operating expenses down by 1% to $27.9 million [13][23]. - The company achieved a net loss of $17.7 million in the second quarter, an improvement of 31% compared to a net loss of $25.4 million in the same quarter of 2024 [13][25]. Cash Position and Future Outlook - As of June 30, 2025, the company had $239.7 million in cash and cash equivalents, with expectations to reach at least $550 million upon closing the transaction with Illumina [6][19]. - The company is targeting adjusted EBITDA break-even in 2026, supported by a strong balance sheet and a lean operating model [3][6]. Strategic Developments - The sale of SomaLogic is seen as a pivotal milestone for the company, allowing for strategic capital deployment into high-quality assets to drive growth and long-term shareholder value [3][6]. - The company anticipates a high single-digit million decline in Americas academic revenue due to NIH funding pressures, impacting continuing operations more significantly [9]. Revenue Outlook - For fiscal year 2025, the company expects combined revenue in the range of $165 million to $175 million, with revenue from continuing operations projected between $78 million and $83 million [8].