北京佰仁医疗科技股份有限公司 累积投票制实施细则 2025 年 8 月 北京佰仁医疗科技股份有限公司 累积投票制实施细则 第一条 为维护中小股东的利益，完善北京佰仁医疗科技股份有限公司（以 下简称"公司"）法人治理结构，规范公司选举董事行为，根据中国证监会《上市 公司治理规则》、《北京佰仁医疗科技股份有限公司章程》（以下简称"《公司 章程》"）及其他有关规定，特制定本实施细则。 第二条 本实施细则所指的累积投票制是指公司股东会在选举两名以上的 董事时采用的一种投票方式。即公司股东会选举董事时，股东所持的每一有效表 决权股份拥有与该次股东会应选董事总人数相等的投票权，股东拥有的投票权等 于该股东持有股份数与应选董事总人数的乘积。股东既可以用所有的投票权集中 投票选举一位候选董事，也可以将投票权分散行使、投票给数位候选董事。得票 数超过出席股东会股东所持有效表决权股份（以未累积的股份数为准）的二分之 一为候选人当选的前提条件，公司按得票多少依次确定最终应选人数范围内的当 选董事。 第三条 股东会选举产生的董事人数及结构应符合《公司章程》的规定。 第四条 本实施细则所称"董事"包括独立董事和非独立董事。由职工代表担 ...

Core Points - The Sci-Tech Innovation 50 Index experienced a slight increase, closing at 1149.15 points with a gain of 0.09% and a trading volume of approximately 657.2 billion [1] - Most stocks on the Sci-Tech board declined, with 165 stocks rising; high-priced stocks showed mixed performance while low-priced stocks mostly fell [1] - In specific sectors, stocks related to environmental protection, healthcare, and biopharmaceuticals were active, whereas semiconductor, communication equipment, and electrical equipment stocks declined [1] Trading Performance - On August 21, the average decline for 589 stocks on the Sci-Tech board was 0.93%, with an average turnover rate of 3.82% and a total trading volume of 217.6 billion [1] - The average volatility for the stocks was 4.64% [1] Individual Stock Performance - Sanwei Xinan led the gainers with a 20% increase, while Dongxin Co. had the largest decline at 12.37% [2] - Cambrian's trading volume was the highest at 11.93 billion, while ST Pava had the lowest at 1.439 million [3] Turnover Rate - Yingshi Innovation had the highest turnover rate at 23.30%, while Bairen Medical had the lowest at 0.28% [4]

Core Viewpoint - The company Baijun Medical has a high rolling price-to-earnings (PE) ratio of 98.10, significantly above the industry average of 59.49, indicating potential overvaluation in the medical device sector [1][2] Company Summary - Baijun Medical's closing stock price on August 19 was 121.43 yuan, down 1.54%, with a total market capitalization of 16.727 billion yuan [1] - The company specializes in the research, production, sales, and service of medical devices, with key products including various types of biological patches and heart valve systems [1] - As of March 31, 2025, the number of shareholders increased to 3,099, with an average holding value of 352,800 yuan and an average shareholding of 27,600 shares [1] - The latest quarterly report for Q1 2025 shows revenue of 100 million yuan, a year-on-year increase of 31.30%, and a net profit of 32.5043 million yuan, up 290.69%, with a gross profit margin of 85.72% [1] Industry Summary - The average PE ratio for the medical device industry is 59.49, with a median of 40.19, positioning Baijun Medical at 104th in the industry ranking [2] - Other companies in the industry have significantly lower PE ratios, with the lowest being 11.65 for Jiuan Medical and the highest being 20.67 for Antu Biology [2]

Core Viewpoint - Beijing Bairen Medical Technology Co., Ltd. has had its application for the registration of a patent foramen ovale (PFO) occluder accepted by the National Medical Products Administration, indicating a significant step in the development of this medical device [1][3]. Group 1: Product Information - The PFO occluder is a self-expanding, mushroom-shaped implant made from nickel-titanium alloy wire, designed to close the abnormal shunt caused by a patent foramen ovale [3]. - The device is intended to prevent complications associated with PFO, such as unexplained strokes and migraines, by effectively blocking the passage between the heart's atria [2][3]. - Clinical studies have shown that the PFO occluder can significantly reduce or eliminate migraine attacks, highlighting its therapeutic potential [2]. Group 2: Market Potential - The incidence of PFO in the general population ranges from 22% to 38%, with rates as high as 32% to 50% in patients with unexplained ischemic strokes, indicating a substantial patient base for the PFO occluder [2]. - The market for PFO occluders is expected to continue growing, with the number of implants increasing from 21,000 in 2021 to an estimated 54,000 by 2024, reflecting a strong demand for this treatment option [2]. Group 3: Regulatory Status - The acceptance of the registration application for the PFO occluder does not guarantee approval, and the company acknowledges the uncertainty regarding the impact of this product on its future performance [3].

Core Viewpoint - The announcement indicates that the registration application for the patent foramen ovale (PFO) occluder developed by the company has been officially accepted by the National Medical Products Administration [2] Company Summary - The company, Baijun Medical, has recently made progress in its product development by having its PFO occluder registration application accepted [2]

Core Viewpoint - Beijing Bairen Medical Technology Co., Ltd. has announced that its application for the registration of a patent foramen ovale (PFO) occluder has been officially accepted by the National Medical Products Administration, indicating progress in the development of this medical device [1]. Group 1: Product Information - The application pertains to a Class III medical device, specifically a PFO occluder, with acceptance number CQZ2501513 [1]. - PFO is a physiological channel left over from embryonic heart septum development, which can lead to various health issues, including unexplained strokes and migraines [1][2]. - The PFO occluder is designed as a self-expanding mushroom-shaped implant made from nickel-titanium alloy wire, lined with a PET polyester membrane, which effectively closes the abnormal shunt [3]. Group 2: Market Potential - The incidence of PFO in the general population ranges from 22% to 38%, and it is found in 32% to 50% of patients with unexplained ischemic strokes [2]. - The market for PFO occluders is expected to continue growing, with increasing recognition of their effectiveness in preventing strokes and reducing migraine symptoms [2][3]. - The product's safety and efficacy have been confirmed through preclinical studies and clinical trials, meeting clinical usage requirements [3].

受理号：CQZ2501513 证券代码：688198 证券简称：佰仁医疗 公告编号：2025-026 北京佰仁医疗科技股份有限公司 关于自愿披露卵圆孔未闭封堵器注册申请获得受理的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 近日，北京佰仁医疗科技股份有限公司（以下简称"公司"）研发的卵圆孔未 闭封堵器注册申请获国家药品监督管理局正式受理，受理信息如下： 申请事项：境内III类医疗器械注册申请 项目名称：卵圆孔未闭封堵器 卵圆孔是心脏房间隔胚胎时期遗留下来的一个生理性通道，大多数人出生后 5~7个月左右融合形成永久性房间隔，若未融合则卵圆窝中间遗留一个永久性的裂缝 样异常通道，即卵圆孔未闭（patent foramentovale，PFO）。PFO可能作为血栓、空 气、脂肪、血管活性物质从静脉系统进入动脉系统的通道，可导致不明原因脑卒中、 短暂性缺血发作、偏头痛、减压病、体位相关性低氧血症等症状，属于结构性心脏 病。 一般人群中PFO的发生率为 22%~38%，而在原因不明的缺血性脑梗死中患PFO 者高达32%~50 ...

格隆汇8月18日丨佰仁医疗(688198.SH)公布，公司研发的卵圆孔未闭封堵器注册申请获国家药品监督管 理局正式受理，作为结构性心脏病介入治疗器械，经导管封堵未闭卵圆孔可使这类患者获得根治。基于 既往十余年先天性心脏病封堵器产品研制与临床应用的积累，公司研发申报产品——卵圆孔未闭封堵 器。该产品是一种自膨胀性蘑菇伞状体内植入性封堵装置，由记忆金属——镍钛合金丝编织而成，内衬 以 PET 聚酯膜作内芯。镍钛合金丝在37℃能够保持定型形状，封堵器植入体内后靠其形态恢复弹力支 撑嵌顿于卵圆孔位置，从而关闭异常分流，实现对卵圆孔的封堵。经临床前研究与临床试验确认，该产 品安全有效性满足临床使用要求。 ...

Group 1 - The core viewpoint of the articles highlights the performance and valuation of Baijun Medical, which has a current stock price of 122.3 yuan, a PE ratio of 98.80, and a total market capitalization of 16.847 billion yuan [1][2] - Baijun Medical's revenue for Q1 2025 reached 100 million yuan, representing a year-on-year increase of 31.30%, while net profit surged to 32.5043 million yuan, up 290.69% year-on-year, with a gross profit margin of 85.72% [1] - The company ranks 104th in the medical device industry based on PE ratio, which has an average of 56.58 and a median of 39.97 [1][2] Group 2 - As of March 31, 2025, Baijun Medical had 3,099 shareholders, an increase of 288 from the previous count, with an average holding value of 352,800 yuan and an average shareholding of 27,600 shares [1] - The main business of Baijun Medical includes the research, production, sales, and service of medical devices, with key products such as biological patches for cardiac and thoracic surgery, artificial heart valves, and other surgical implant devices [1]

Group 1 - The core viewpoint of the articles highlights a positive trend in the medical device sector, with major stocks experiencing significant gains, indicating a recovery in the market [1] - The medical device index ETF (159898) showed a morning rebound with a rise of 1.03%, attracting over 15 million yuan in net subscriptions, reflecting investor confidence [2] - Future growth in the medical device industry is expected to be driven by technological advancements, AI diagnostics, and the expansion of consumer healthcare, transitioning to a higher development stage [2] Group 2 - Financial institutions like Caixin Securities maintain a "leading the market" rating for the medical device sector, anticipating high-quality development and long-term investment opportunities [2] - The impact of centralized procurement in high-cost areas is gradually diminishing, with some products benefiting from renewed contracts, suggesting a potential for volume and price increases in the coming years [2] - The medical device index ETF (159898) has seen a cumulative net value increase of 22.82% over the past year, outperforming its benchmark by 5.99%, ranking first among similar index ETFs [2][3]