经济观察网普蕊斯（301257）近期财务业绩改善，业务规模持续扩大，数字化平台应用深化，行业集中 化趋势明显，并受到机构关注。 业务与技术发展 公司通过自研平台如"蕊星"智能管理系统，集成AI功能提升临床试验效率。2025年投资者关系活动显 示，该平台已实现数据可视化与智能化管理，助力服务质量提升。 行业政策与环境 根据2026年2月的投资者活动，SMO行业资源正逐步向头部企业集中，普蕊斯作为领先企业，受益于监 管政策支持和客户资源积累，行业竞争格局优化。 机构调研 2026年1月，公司接待了汇添富基金等多家机构调研，讨论内容包括业务战略和质量管理体系。近一年 累计接待机构210家，反映市场关注度较高。 业绩经营情况 公司2025年三季报显示，前三季度营收6.09亿元，同比增长2.59%；归母净利润8738.15万元，同比增长 20.92%。单季度来看，第三季度营收2.19亿元，同比增长9.84%，净利润3322.54万元，同比大幅增长 91.6%，毛利率提升至25.58%。这些数据反映公司盈利能力的回升。 业务进展情况 截至2025年9月末，公司累计承接国际和国内SMO项目超4200个，在执行项目2538个 ...

证券日报网讯2月12日，普蕊斯（301257）在互动平台回答投资者提问时表示，截至2026年1月30日收 盘，公司股东总数为9520户。 ...

Investment Rating - The report maintains a "Buy" rating for key companies in the pharmaceutical sector, including Innovent Biologics, Efang Biologics, Tianshili, WuXi AppTec, and Mindray Medical [4][28]. Core Insights - The policy-driven upgrade of traditional Chinese medicine (TCM) industry is expected to enhance industry concentration in the medium to long term, benefiting companies with strong quality control and innovative capabilities [2][24]. - The implementation plan for high-quality development of the TCM industry aims to establish a collaborative development system by 2030, focusing on raw material supply, innovation, production quality control, and internationalization [2][23]. - The investment strategy emphasizes the importance of clinical value in the pharmaceutical sector, recommending a focus on innovative drugs and high-end medical devices [3][26]. Summary by Sections Market Review - The A-share pharmaceutical index rose by 0.14%, outperforming the CSI 300 index by 1.47 percentage points [1][16]. - The Hong Kong Hang Seng Medical Health Index fell by 1.41%, but still outperformed the Hang Seng Index by 1.65 percentage points [1][16]. Policy Insights - The Ministry of Industry and Information Technology and other departments issued a plan to enhance the TCM industry, which includes fostering leading enterprises and establishing high-standard raw material production bases [2][24]. - The plan emphasizes digitalization and sustainability, aiming to raise compliance standards and accelerate the exit of smaller companies from the market [2][25]. Company Updates - Recent clinical progress includes the NDA submission for HRS-9531 by Heng Rui Medicine and the initiation of clinical trials for various drugs by other companies [1][31][32]. - Key companies such as Yunnan Baiyao, Baiyunshan, and Taiji Group are highlighted for their strong positions in raw material supply [2][25]. Financial Forecasts - The report provides earnings per share (EPS) forecasts for key companies, with Innovent Biologics projected to have an EPS of 0.49 in 2025 and WuXi AppTec expected to reach an EPS of 5.07 in the same year [4][28]. - The pharmaceutical manufacturing industry reported a revenue decline of 1.2% year-on-year for 2025, with total revenue reaching 2,487 billion yuan [51].

Group 1 - The company, 普蕊斯, announced that it will conduct investor research from January 26, 2026, to January 29, 2026, and again from February 2, 2026, to February 4, 2026, with participation from its board secretary, 赖小龙 [1] - The company is engaging with investors, including 招商基金, to address their inquiries during these research sessions [1] Group 2 - A separate investigation revealed unexpected findings regarding the legality of personal stock trading by fund managers, as reported by multiple leading public funds [1]

Company Overview - Proris is a data-driven clinical research service provider focused on patient-centered clinical trials, aiming to enhance the efficiency and compliance of clinical trial management for innovative drug development [1][2] - Since its establishment, Proris has undertaken over 4,200 SMO projects, with 2,538 currently active, and has a workforce of 4,271 employees [2] - The company has served over 960 clinical trial institutions across more than 200 cities in China, benefiting over 420,000 participants and assisting in the approval of over 210 new drugs [2] Financial Performance - Proris has distributed a total of CNY 46.1455 million in cash dividends since its listing, reflecting a commitment to shareholder returns [2] Industry Demand - In 2025, the number of drug clinical trials in China reached 5,173, a year-on-year increase of 6.44%, with 76 innovative drugs approved, marking a 58% increase [3] - China holds approximately 30% of the global new drug pipeline, ranking second worldwide, indicating a vibrant landscape for innovative drug development [3] Market Trends - The total value of innovative drug licensing transactions in China exceeded USD 130 billion in 2025, with over 150 transactions, setting a historical record [3] - The SMO industry is experiencing a trend towards consolidation, with leading firms expanding their client resources and operational capabilities, while smaller firms are gradually exiting the market [4] Client Base - Proris primarily serves multinational pharmaceutical companies, domestic innovative drug firms, and CROs, collaborating with all of the top 10 global pharmaceutical companies as of 2024 [5] Digital Transformation - The company emphasizes the development and application of digital and intelligent technologies as a key strategic focus, aiming to enhance project execution efficiency through a collaborative clinical trial management platform [6] Quality Management - Proris has established a comprehensive quality management system, having undergone 281 inspections by national and provincial authorities, as well as 14 FDA and 5 EMA inspections, with no major findings reported [7][9] - The company maintains over 280 standard operating procedures (SOPs) to ensure compliance and quality in its operations [9]

Core Viewpoint - The ChiNext Medical Index (970082) closed at 3876.07 points on February 3, with a gain of 2.37% and a trading volume of 13.236 billion yuan, indicating positive market sentiment in the medical sector [1]. Group 1: Index Performance - The ChiNext Medical Index saw 49 constituent stocks rise, with NuoSiGe leading the gains at 8.76% [1]. - The index's turnover rate was 1.71%, reflecting moderate trading activity [1]. Group 2: Top Constituents - The top ten constituents of the ChiNext Medical Index include: - YuanEr Eye Hospital (sz300015) with a weight of 9.18% and a latest price of 11.04 yuan, up 1.28% [1]. - MaiRui Medical (sz300760) with a weight of 8.95% and a latest price of 188.15 yuan, up 0.56% [1]. - TaiGe Medical (sz300347) with a weight of 8.52% and a latest price of 63.20 yuan, up 4.97% [1]. - KangLong HuaCheng (sz300759) with a weight of 7.18% and a latest price of 29.61 yuan, up 2.10% [1]. - LePu Medical (sz300003) with a weight of 4.96% and a latest price of 17.83 yuan, up 1.89% [1]. - New Industry (sz300832) with a weight of 4.73% and a latest price of 54.50 yuan, up 2.60% [1]. - AiMeiKe (sz300896) with a weight of 4.49% and a latest price of 147.57 yuan, up 4.56% [1]. - YingKe Medical (sz300677) with a weight of 4.14% and a latest price of 40.55 yuan, up 1.38% [1]. - FuRui Medical (sz300049) with a weight of 3.55% and a latest price of 67.33 yuan, up 1.45% [1]. - HuaDa Gene (sz300676) with a weight of 3.15% and a latest price of 50.30 yuan, up 2.57% [1]. Group 3: Capital Flow - The net inflow of main funds into the ChiNext Medical Index constituents totaled 145 million yuan, while retail investors experienced a net outflow of 106 million yuan [1]. - The detailed capital flow indicates that TaiGe Medical had a main fund net inflow of 10.514 million yuan, while retail investors had a net outflow of 18.28% [2].

Investment Rating - The investment rating for the healthcare industry is "Positive" and maintained [14] Core Insights - The funding levels for Chinese innovative pharmaceutical companies are increasing, leading to a gradual improvement in the research and development (R&D) investment sentiment within the industry. This is expected to usher in a new cycle of prosperity for the innovative drug industry chain [5][12] - The trend of external business development (BD) is likely to benefit the domestic early-stage research industry significantly, as new business models allow early-stage projects to become tradable and monetizable assets, enhancing R&D investment returns [13] Summary by Sections Innovative Chain Development Review - Before 2020, multiple factors converged to initiate a significant rise in China's innovative drug sector, leading to the rapid development of the innovative chain, including CXO and life sciences services [10][30] - From 2020 to the first half of 2022, the global public health crisis accelerated capital inflow into the biopharmaceutical sector, resulting in high demand and a leap in the innovative chain segment, which also triggered a wave of IPOs and substantial supply-side expansion [10][39] - The second half of 2022 to 2024 saw a transition from a heated to a cooling phase, with a significant shift in supply-demand dynamics leading to industry internal competition and pressure on revenues and profit margins [10][54][57] Improvement in R&D Investment Sentiment - Starting from 2025, the R&D investment sentiment in China's innovative drug sector is expected to improve, with companies experiencing increased funding levels. The total amount raised through IPOs and additional offerings in 2025 is projected to reach 201.5 billion yuan, a 145% year-on-year increase [11][62] - The potential milestone payments from external BD are expected to reach 880.5 billion yuan in 2025, marking a 185.9% year-on-year increase, indicating a robust funding environment for innovative drug companies [11] Benefits to Early-stage Research Industry - The new external BD business model enhances the R&D investment return rates for Chinese innovative drug companies, thereby increasing their willingness to invest in R&D [11][13] - The early-stage research industry, including drug discovery CROs and clinical trial services, is expected to benefit significantly from the external BD trend, with leading companies in these segments poised for rapid growth [13]

Group 1 - The company, Puris (301257), reported that as of January 30, 2026, the total number of shareholders is 9,520 [1]

证券日报网讯1月23日，普蕊斯（301257）在互动平台回答投资者提问时表示，截至2025年12月31日收 盘，公司股东总数为6759户。 ...

Group 1 - The core viewpoint of the news is that 普蕊斯 (Puris) has shown fluctuations in its stock performance and financing activities, indicating a high level of trading activity and potential investor interest [1][2]. - On January 22, 2023, 普蕊斯 experienced a stock price decline of 2.63%, with a trading volume of 170 million yuan. The financing buy-in amount was 11.01 million yuan, while the financing repayment was 21.17 million yuan, resulting in a net financing outflow of 10.16 million yuan [1]. - As of January 22, 2023, the total balance of margin trading for 普蕊斯 was 80.46 million yuan, with the financing balance accounting for 1.51% of the circulating market value, indicating a high level compared to the past year [1]. Group 2 - As of December 31, 2022, 普蕊斯 had 6,759 shareholders, a decrease of 18.42% from the previous period, while the average circulating shares per person increased by 22.58% to 11,143 shares [2]. - For the period from January to September 2025, 普蕊斯 reported a revenue of 609 million yuan, representing a year-on-year growth of 2.59%, and a net profit attributable to shareholders of 87.38 million yuan, which is a 20.92% increase year-on-year [2]. - Since its A-share listing, 普蕊斯 has distributed a total of 46.15 million yuan in dividends [3].