Core Insights - Eli Lilly and Company reported a strong financial performance in Q1 2025, with a 45% year-over-year revenue growth driven by robust sales of Mounjaro and Zepbound [2][3][7] - The company is investing in manufacturing to meet global demand for its new medicines, including plans to build four new facilities [2][19] - The pipeline continues to show promise with recent product approvals in oncology and immunology, and positive Phase 3 trial results for orforglipron in diabetes and obesity [2][19] Financial Results - Total revenue for Q1 2025 was $12.73 billion, a 45% increase from $8.77 billion in Q1 2024, primarily due to a 53% increase in volume [3][7] - Net income for Q1 2025 was $2.76 billion, up 23% from $2.24 billion in Q1 2024, with reported earnings per share (EPS) increasing to $3.06 from $2.48 [11][36] - Non-GAAP net income was $3.00 billion, a 29% increase from $2.34 billion in Q1 2024, with non-GAAP EPS rising to $3.34 from $2.58 [13][36] Revenue Breakdown - U.S. revenue increased by 49% to $8.49 billion, driven by a 57% increase in volume, mainly from Zepbound and Mounjaro [4][7] - Revenue outside the U.S. rose 38% to $4.24 billion, with a 46% increase in volume, primarily from Mounjaro and Jardiance [5][7] - Mounjaro revenue surged 113% to $3.84 billion, while Zepbound revenue reached $2.31 billion, up from $517.4 million in Q1 2024 [16][17] Cost and Margin Analysis - Gross margin increased 48% to $10.50 billion, with a gross margin percentage of 82.5%, up 1.6 percentage points from the previous year [6][11] - Research and development expenses rose 8% to $2.73 billion, representing 21.5% of revenue, while marketing, selling, and administrative expenses increased 26% to $2.47 billion [8][11] Guidance and Future Outlook - The company reaffirmed its 2025 revenue guidance of $58.0 billion to $61.0 billion, with an expected performance margin of 40.5% to 42.5% on a reported basis [20][22] - The effective tax rate for 2025 is projected to be around 17%, up from approximately 16% [21][22] - EPS guidance for 2025 has been adjusted to a range of $20.17 to $21.67 on a reported basis, reflecting the impact of acquired IPR&D charges [22][23]

Earnings Report - Eli Lilly is set to release its Q1 earnings results on May 1, with expected earnings of $3.46 per share, an increase from $2.58 per share year-over-year [1] - The company projects quarterly revenue of $12.72 billion, up from $8.77 billion in the same period last year [1] Clinical Trial Results - On April 17, Eli Lilly reported positive Phase 3 results from the ACHIEVE-1 trial of orforglipron for adults with type 2 diabetes [2] - Following the announcement, Eli Lilly shares rose by 1.6%, closing at $898.95 [2] Analyst Ratings - HSBC downgraded Eli Lilly from Buy to Reduce, lowering the price target from $1,150 to $700 [8] - Guggenheim maintained a Buy rating but reduced the price target from $973 to $928 [8] - Morgan Stanley kept an Overweight rating, cutting the price target from $1,146 to $1,124 [8] - Goldman Sachs upgraded the stock from Neutral to Buy, lowering the price target from $892 to $888 [8] - Wells Fargo maintained an Overweight rating and increased the price target from $970 to $1,100 [8]

Eli Lilly And Co LLY will be reporting its first-quarter earnings on Thursday. Wall Street expects $3.05 in EPS and $12.67 billion in revenues as the company reports before market hours.The stock is up 14.35% over the past year, 14.79% YTD.Let’s examine the charts for Eli Lilly stock and how it currently compares to Wall Street estimates.Read Also: $1000 Invested In This Stock 20 Years Ago Would Be Worth This Much TodayLLY Stock Chart Strongly Bullish Ahead Of Q1 EarningsChart created using Benzinga ProEli ...

Group 1: Company Overview - Eli Lilly is the most valuable healthcare company globally, with a market cap of approximately $800 billion, and is considered a promising long-term investment due to its dominance in the GLP-1 drug market [1] - The company experienced a 32% increase in sales last year, driven by the popularity of its GLP-1 drugs, Zepbound and Mounjaro, which generated a combined $16.5 billion in sales [2][6] Group 2: Legal and Market Challenges - Eli Lilly is suing compounding pharmacies that have been offering knock-off versions of its GLP-1 drugs, which could divert sales and negatively impact the brand's perception if patients experience side effects from these unapproved products [3][4] Group 3: Future Growth Catalysts - Eli Lilly is developing a daily weight loss pill, orforglipron, which could significantly change the industry landscape, as current GLP-1 treatments are injectables [5] - Positive results from a late-stage trial of orforglipron indicate potential for weight loss and blood sugar reduction, boosting investor confidence [6] - The company plans to release data from nine studies related to orforglipron's performance throughout the year, with the final results expected in October [7] - Approval for orforglipron could occur next year, and strong trial results may lead to significant stock price increases [8] Group 4: Investment Considerations - Despite trading at over 70 times its trailing earnings, Eli Lilly is viewed as a potentially strong buy due to anticipated growth, especially if the weight loss and diabetes pill receives approval [9]

Group 1 - Eli Lilly and Company has experienced favorable conditions in the obesity and adjacent markets over the last couple of quarters [2] - The main competitor in this space is Novo Nordisk A/S, indicating a competitive landscape [2] Group 2 - The article emphasizes the importance of tracking portfolio and watchlist stocks closely to identify attractive risk/reward situations [2]

Core Viewpoint - Eli Lilly and Company is set to report its first-quarter earnings on May 1, with sales and earnings estimates at $12.62 billion and $3.52 per share, respectively. However, earnings estimates for 2025 have seen a decline from $23.53 to $22.43 per share over the past month [1][4]. Earnings Performance - The company has had a mixed earnings performance, exceeding expectations in three of the last four quarters, with an average earnings surprise of 8.47% [2][3]. Earnings Estimates and Trends - Current earnings estimates for Q1, Q2, 2025, and 2026 are $3.52, $5.58, $22.43, and $31.15 per share, respectively. Notably, the earnings estimate for Q1 has decreased by 22.30% over the past month [1][4]. Factors Influencing Upcoming Results - Top-line growth in Q1 is expected to be driven by demand for FDA-approved tirzepatide medicines, specifically the diabetes drug Mounjaro and weight loss medicine Zepbound. However, sales of these drugs were below expectations in the latter half of 2024 due to slower growth and unfavorable channel dynamics [5][6]. Sales Estimates for Key Products - The Zacks Consensus Estimate for Mounjaro and Zepbound is $3.75 billion and $2.27 billion, respectively, while the company's estimates are $3.82 billion and $2.19 billion. Increased demand for other key growth drugs is also anticipated to support top-line growth [8][10]. Competitive Landscape - Sales of Trulicity are expected to decline due to competitive dynamics and lower realized prices in the U.S., with patient switches to Mounjaro impacting its performance [9][22]. The obesity market is becoming increasingly competitive, with several companies developing GLP-1-based candidates [23][24]. Stock Performance and Valuation - Lilly's stock has risen 14.8% year-to-date, outperforming the industry and the S&P 500 index. The stock is currently trading at a premium compared to the industry [13][16]. Investment Outlook - Despite challenges, including declining sales of key products and increasing competition, the company is viewed as having robust growth prospects, particularly with new product launches and expansions planned for 2025 [20][25].

Core Viewpoint - Eli Lilly And Co (NYSE: LLY) has experienced a double downgrade from HSBC, with a price target cut, raising concerns about competition and valuation [1] Group 1: Stock Performance - Eli Lilly's stock is currently trading at $870.31, down 1.6% following the downgrade [1] - Despite the recent decline, the stock has a year-to-date gain of 12.8% and is trading above the 200-day moving average [2] Group 2: Analyst Ratings - Prior to the downgrade, 22 out of 25 analysts had a "buy" or better rating on the stock, with a 12-month consensus target price of $998.05, indicating a 14.3% premium to current levels [1] Group 3: Options Market Sentiment - Short-term options traders are showing bearish sentiment, as indicated by a Schaeffer's put/call open interest ratio (SOIR) of 1.13, which is in the 95th percentile of the past 12 months [3]

Core Viewpoint - Eli Lilly and Company is set to report its first-quarter earnings on May 1, with sales and earnings estimates at $12.62 billion and $3.52 per share respectively, while earnings estimates for 2025 have seen a decline from $23.53 to $22.43 per share over the past month [1][4]. Earnings Performance - The company has exceeded earnings expectations in three of the last four quarters, with an average earnings surprise of 8.47% [2][3]. - The last reported quarter showed an earnings surprise of 5.77% [2]. Earnings Estimates and Trends - Current earnings estimates for Q1, Q2, 2025, and 2026 are $3.52, $5.58, $22.43, and $31.15 respectively, with a notable decline in Q1 estimates from $4.64 to $3.52 over the past 30 days, reflecting a -22.30% revision [1][4]. Factors Influencing Upcoming Results - Top-line growth in Q1 is expected to be driven by demand for FDA-approved tirzepatide medicines, specifically diabetes drug Mounjaro and weight loss medicine Zepbound [5]. - Sales of Mounjaro and Zepbound were below expectations in the latter half of 2024, attributed to slower growth and unfavorable channel dynamics [5][6]. - The FDA's approval of Zepbound for moderate-to-severe obstructive sleep apnea is anticipated to contribute positively to sales [7]. Sales Estimates for Key Products - The Zacks Consensus Estimate for Mounjaro and Zepbound is $3.75 billion and $2.27 billion respectively, while internal estimates are $3.82 billion and $2.19 billion [8]. - Sales estimates for other drugs include Trulicity at $1.11 billion, Taltz at $663 million, Verzenio at $1.25 billion, Jardiance at $675 million, Olumiant at $228 million, and Emgality at $220 million [10]. Competitive Landscape - Lilly faces competition in the diabetes and obesity market, particularly from Novo Nordisk's Wegovy, with several companies developing GLP-1-based candidates that could threaten market dominance [22][23]. - Despite competition, Lilly is investing in obesity treatments and has new molecules in clinical development, including a promising oral GLP-1 agonist [24]. Stock Performance and Valuation - Lilly's stock has increased by 14.8% this year, outperforming the industry average of 1.5% [13]. - The stock is currently trading at a premium compared to the industry [16]. Investment Outlook - Despite challenges, Lilly is viewed as a strong investment due to its robust growth prospects and position as a leading drugmaker [25].

Core Insights - The article discusses the author's extensive background in biomedicine and bioengineering, emphasizing over 20 years of experience in the research and development of novel Cell & Gene Therapies (CGT) aimed at addressing various clinical needs [1] - The author aims to leverage their expertise in life sciences to evaluate the potential of innovative treatments, particularly those utilizing CGT, and their ability to generate shareholder returns [1] Group 1 - The author has a Master of Science in Biomedicine and a PhD in Bioengineering, highlighting a strong academic foundation in relevant fields [1] - The focus will be on analyzing biotechnology, pharmaceutical, Medtech, and healthcare stocks, providing insights into company performance and market potential [1] Group 2 - The author is associated with another contributor but emphasizes independent work and adherence to guidelines [1] - There is a clear statement of no current stock or derivative positions in the companies mentioned, indicating an unbiased perspective [2]

Core Viewpoint - An analyst from BMO Capital has reduced the price target for Eli Lilly's stock despite positive news regarding its pipeline drug, indicating a complex market sentiment towards the company [1][2]. Company Summary - The new price target for Eli Lilly is set at $900 per share, reflecting a decrease of $110 from the previous assessment, while the analyst maintains an outperform recommendation [2]. - The analyst expressed optimism about Eli Lilly's obesity drug, Zepbound, which is reportedly outperforming Novo Nordisk's Wegovy, the only other FDA-approved GLP-1 treatment for weight loss [3][4]. - Concerns were raised regarding the broader macroeconomic environment, suggesting that economic pressures are impacting the healthcare sector, making Eli Lilly vulnerable [3]. Industry Summary - The pharmaceutical sector is viewed as more resilient compared to other industries amid a volatile global macroeconomy, as many drugs, including obesity treatments, are considered essential for patients [5]. - The ongoing trade war is expected to contribute to economic instability, but pharmaceutical companies like Eli Lilly are better insulated from these pressures [5].