Core Viewpoint - Shanghai Sanyou Medical Instrument Co., Ltd. has signed a strategic cooperation and distribution agreement with CGBio Co., Ltd. to obtain exclusive distribution rights for the Novosis product in mainland China, which is expected to enhance the company's product line and competitive strength in the orthopedic biomaterials sector [2][4][20]. Agreement Overview - The agreement grants Sanyou Medical exclusive and non-transferable rights to procure, import, market, distribute, sell, promote, and conduct other commercial activities related to the Novosis product in mainland China for a period of six years, starting from the date the product receives medical device registration from the National Medical Products Administration of China [2][9][10]. Product Details - Novosis is a biomaterial product containing recombinant human bone morphogenetic protein BMP-2 and hydroxyapatite ceramic, designed for synthetic bone grafting. It is produced using genetically engineered E. coli and is packaged with a disposable syringe and needle [3][11][19]. - The product is known for its strong osteoconductive and osteoinductive properties, promoting the formation of new bone and cartilage, and is widely used in various surgical repairs, including spinal fusion and trauma [12][20]. Impact on the Company - The exclusive distribution rights for Novosis will enrich Sanyou Medical's product offerings and enhance its position in the orthopedic biomaterials market, providing comprehensive surgical solutions for patients and doctors, which is expected to positively impact the company's operations [4][20]. - Sanyou Medical is recognized as a leading company in the development, production, and sales of orthopedic implant consumables, with strong market sales channels and a rich customer base [18]. Partner Company Overview - CGBio Co., Ltd. is a South Korean company specializing in the research, production, and sales of medical device biomaterials, with significant expertise in various core technologies related to tissue regeneration and implant design [18].

Core Viewpoint - The company has signed a strategic cooperation and distribution agreement with CGBio, granting exclusive rights to distribute Novosis products in mainland China, which is expected to enhance its competitive strength in the orthopedic biomaterials sector [1][3]. Group 1: Agreement Details - The agreement was signed on December 2, 2025, and grants the company exclusive, non-transferable rights for procurement, import, marketing, distribution, sales, promotion, and other commercialization activities for Novosis products in mainland China [1]. - The authorization is valid for six years from the date the products receive medical device registration from the National Medical Products Administration of China [1]. Group 2: Product Information - Novosis is a synthetic bone graft material composed of recombinant human bone morphogenetic protein BMP-2 and hydroxyapatite ceramic, packaged with a disposable syringe and needle [2]. - The product is produced through genetic engineering from human rhBMP-2 cDNA and is designed to promote new bone formation with strong osteoconductive and osteoinductive properties [2]. - It is widely used in various surgical repair and reconstruction applications, including spinal fusion, limb trauma, and oral surgery [2]. Group 3: Strategic Impact - Acquiring exclusive distribution rights for Novosis products will enrich the company's product line and enhance its positioning in the orthopedic biomaterials market, providing comprehensive surgical solutions for patients and doctors [3]. - This move is expected to positively impact the company's operations and overall competitiveness in the industry [3].

上海三友医疗器械股份有限公司 关于公司与韩国细基生物株式会社签署 战略合作和经销协议的自愿披露公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 协议概述：上海三友医疗器械股份有限公司（以下简称"公司"或"三 友医疗"）与韩国细基生物株式会社（CGBio Co., Ltd.）（以下简称"CGBIO"或 "韩国细基生物"）于 2025 年 12 月 2 日签署了《战略合作和经销协议》（以下简 称"合作协议"），根据协议约定：在中国大陆地区，CGBIO 对协议产品 Novosis 产品（以下简称"经销产品"）授予三友医疗进行采购、进口、营销、分销、销 售、推广、要约销售、促成销售及其他商业化活动的独家、不可转让权利。授权 有效期为经销产品获得中国国家药品监督管理局（以下简称"中国药监局"）颁 发医疗器械注册证之日起六年。 证券代码：688085 证券简称：三友医疗 公告编号：2025-088 协议对方名称：细基生物株式会社（CGBio Co., Ltd.） 性质：股份有限公司 （一）协议对方的基本情况 一、协 ...

Core Viewpoint - The company has signed a strategic cooperation and distribution agreement with CGBio, granting exclusive rights to distribute Novosis products in mainland China for six years after obtaining regulatory approval [1][3]. Group 1: Agreement Details - The agreement allows the company to engage in procurement, import, marketing, distribution, sales, promotion, and other commercialization activities for Novosis products in mainland China [1]. - The exclusivity of the rights is contingent upon the product receiving a medical device registration certificate from the Chinese National Medical Products Administration [1]. Group 2: Product Information - Novosis is a synthetic bone graft material composed of recombinant human bone morphogenetic protein BMP-2 and hydroxyapatite ceramic, packaged with a disposable syringe and needle [2]. - The product is produced using genetically engineered E. coli to efficiently produce rhBMP-2, which promotes new bone formation and has strong osteoconductive and osteoinductive properties [2]. - rhBMP-2 is widely used in various surgical repair and reconstruction applications, including spinal fusion, limb trauma, and oral surgery [2]. Group 3: Strategic Impact - Acquiring exclusive distribution rights for Novosis will enhance the company's product line and strengthen its position in the orthopedic biomaterials sector, providing comprehensive surgical solutions for patients and doctors [3]. - This development is expected to positively impact the company's overall competitiveness and operational performance [3].

Core Viewpoint - Company signed a strategic cooperation and distribution agreement with CGBIO for exclusive rights to market and distribute Novosis products in mainland China, enhancing its competitive position in the orthopedic biomaterials sector [1][2] Group 1: Agreement Details - The agreement grants the company exclusive, non-transferable rights for procurement, import, marketing, distribution, sales, promotion, and other commercialization activities for Novosis products in mainland China [1] - The authorization is valid for six years from the date the products receive medical device registration from the Chinese regulatory authority [1] Group 2: Product Information - Novosis is a synthetic bone graft material composed of recombinant human bone morphogenetic protein BMP-2 and hydroxyapatite ceramic, packaged with a disposable syringe and needle [1] - The product is produced using genetically engineered E. coli to efficiently manufacture rhBMP-2, which promotes new bone formation and has strong osteoconductive and osteoinductive properties [1] Group 3: Market Impact - The acquisition of exclusive distribution rights for Novosis will enrich the company's product line and enhance its offerings in the orthopedic biomaterials field [2] - This development is expected to provide comprehensive surgical solutions for patients and doctors, positively impacting the company's operations and overall competitiveness [2]

Core Viewpoint - The company has signed a strategic cooperation and distribution agreement with a South Korean firm, obtaining exclusive and non-transferable distribution rights for Novosis products in mainland China, which will enhance its product line in the orthopedic biomaterials sector [1] Group 1: Agreement Details - The agreement was signed on December 2, 2025, with a validity period of six years from the date the product receives medical device registration from the Chinese regulatory authority [1] - Novosis is a recombinant human bone morphogenetic protein BMP-2 biomaterial product that promotes new bone formation [1] Group 2: Impact on Company - This collaboration will enrich the company's product offerings and improve its positioning in the orthopedic biomaterials market [1] - However, there is uncertainty regarding the product's registration approval and market launch, making it difficult to predict the specific impact on the company's performance [1]

Core Viewpoint - The announcement details the reduction of shareholding by the actual controller and their concerted actors in Shanghai Sanyou Medical Instrument Co., Ltd, indicating a significant change in ownership structure and potential implications for the company's governance and market perception [1][10]. Summary by Sections Basic Information - The actual controller, Xu Nong, and his concerted actor, Chaos Tiancheng Asset Management - Xu Nong - Chaos Tiancheng Selected Strategy No. 18, held 8,881,404 shares, representing 2.66% of the total share capital before the reduction [2]. - Xu Nong directly holds 39,297,975 shares, while other concerted actors, Michael Mingyan Liu and David Fan, hold 30,341,922 shares and 16,335,114 shares respectively, totaling 94,856,415 shares or 28.45% of the company [2]. Results of the Reduction Plan - The reduction plan was disclosed on August 14, 2025, with a maximum of 6,669,249 shares to be sold through block trading, not exceeding 2.00% of the total share capital [3]. - The reduction period was set from September 8, 2025, to December 7, 2025, with a limit of 2% of total shares sold within any 90-day period [3]. Actual Reduction Situation - From September 8 to September 12, 2025, 2,140,000 shares were sold through block trading, followed by an additional 4,529,249 shares sold from September 13 to December 1, 2025, completing the reduction plan [4][5]. - The total reduction amounted to 4,529,249 shares, representing 1.36% of the total share capital, reducing the combined holdings of Xu Nong and his concerted actors from 92,716,415 shares to 88,187,166 shares, a decrease in ownership percentage from 27.80% to 26.45% [5][9]. Additional Notes - The reduction does not trigger a mandatory tender offer and does not involve any change in the actual controller or significant impact on the company's governance structure [10][12]. - The company will continue to monitor compliance with reduction regulations and ensure timely disclosure of relevant information to investors [12].

Core Insights - A total of 15 stocks on the Sci-Tech Innovation Board experienced block trading on December 1, with a cumulative transaction amount of 360 million yuan [1][2]. Group 1: Trading Overview - There were 41 block trades executed, with a total trading volume of 10.18 million shares [1]. - The stock with the highest transaction amount was Guobo Electronics, which had 6 block trades totaling 7.306 million yuan [1]. - Other notable stocks in terms of transaction amounts included Haitai New Light and Lianyun Technology, with 4.872 million yuan and 3.81983 million yuan respectively [1]. Group 2: Price and Discount Analysis - All stocks involved in block trading were sold at a discount, with the highest discount rates observed in Sanyou Medical, Delong Laser, and Puyuan Information, at 16.46%, 12.68%, and 11.99% respectively [1][2]. - The average decline for stocks that underwent block trading was 0.46%, while the Sci-Tech 50 Index rose by 0.72% [1]. Group 3: Institutional Participation - Institutional transactions accounted for 18 trades involving 5 stocks, with Guobo Electronics leading in institutional buy amounts at 68.9976 million yuan [2]. - The stocks with the highest net inflow of funds included Hush Silicon Industry, Aerospace Software, and Haitai New Light, with net inflows of 20.4385 million yuan, 18.4593 million yuan, and 2.7452 million yuan respectively [2]. Group 4: Detailed Trading Data - A detailed table of block trading data includes various stocks, their transaction counts, volumes, average transaction prices, discount rates relative to closing prices, and total transaction amounts [3].

Group 1 - The core transaction on December 1 involved a block trade of 2.0792 million shares of Sanyou Medical, with a transaction value of 31.9788 million yuan, at a price of 15.38 yuan, which represents a discount of 16.46% compared to the closing price of the day [2][3] - The buyer of the block trade was from Industrial Securities Co., Ltd., Shanghai Jinling East Road Securities Office, while the seller was from Huatai Securities Co., Ltd., Beijing Yonghe Palace Securities Office [2][3] - Over the past three months, Sanyou Medical has recorded a total of four block trades, amounting to a cumulative transaction value of 112 million yuan [2] Group 2 - The latest margin financing balance for Sanyou Medical is 133 million yuan, with a decrease of 1.5733 million yuan over the past five days, reflecting a decline of 1.17% [3] - As of December 1, the closing price of Sanyou Medical was 18.41 yuan, down by 1.29%, with a daily turnover rate of 0.80% and a total transaction amount of 46.0374 million yuan [2] - The net outflow of main funds for the day was 1.0321 million yuan, while the cumulative net inflow of funds over the past five days was 955,500 yuan [2]

Group 1 - On December 1, Sanyou Medical executed a block trade of 2.0792 million shares, with a transaction value of 31.9788 million yuan, accounting for 40.99% of the total trading volume for that day [1] - The transaction price was 15.38 yuan, representing a discount of 16.46% compared to the market closing price of 18.41 yuan [1]