Investment Rating - The report maintains a "Buy" rating for the company, with an expected relative return of over 20% in the next 6 months [7][24] Core Views - The company's 2024Q2 performance exceeded expectations, achieving non-GAAP operating profit for the first time [1] - Revenue growth in 2024H1 was strong, with total revenue reaching $1.68 billion, a 61% YoY increase [1] - The company's core product, Zanubrutinib, showed rapid growth in the US market, with Q2 sales reaching $479 million, a 114% YoY increase [3][12] - Tislelizumab continued to expand its market in China, with Q2 sales of $158 million, a 6% YoY increase [4][15] - R&D and sales expense ratios significantly decreased, contributing to improved operational efficiency [2] Financial Performance - 2024Q2 revenue was $929 million, a 56% YoY increase, with a net loss of $120 million, a 68% YoY reduction in losses [1] - Adjusted operating profit for 2024Q2 reached $48.46 million, marking the first quarterly profit [1] - R&D expenses for 2024Q2 were $454 million, with an expense ratio of 49%, a 22 percentage point YoY decrease [2] - Sales and administrative expenses for 2024Q2 were $444 million, with an expense ratio of 48%, a 19 percentage point YoY decrease [2] Product Performance - Zanubrutinib global sales reached $1.126 billion in 2024H1, a 61% YoY increase, with Q2 sales of $637 million, a 107% YoY increase [3] - In the US, Zanubrutinib sales accounted for 29.44% of the BTK inhibitor market in 2024Q2, up from 1.16% in 2021Q2 [14] - Tislelizumab's total revenue in 2024H1 was $303 million, a 15% YoY increase, with Q2 revenue of $158 million, a 6% YoY increase [4] Pipeline Progress - Sonrotoclax, a BCL2 inhibitor, completed the first patient enrollment for its Phase III trial in combination with Zanubrutinib for TN CLL patients [4] - BGB-16673, a BTK CDAC drug, entered Phase I/II clinical trials for B-cell malignancies, showing promising safety and anti-tumor activity in early data [4] Market Expansion - Zanubrutinib gained approval for its sixth indication in China for FL treatment in May 2024 [3] - Tislelizumab received new approvals in China for gastric cancer and small cell lung cancer in 2024Q2, bringing its total approved indications in China to 11 [4][15] - Tislelizumab's esophageal squamous cell carcinoma treatment was approved in the US in March 2024, with its first-line treatment for the same indication under review [4]

於2024年8月9日，董事會及╱或董事會薪酬委員會根據2016期權及激勵計劃的 條款向五名承授人授出可認購合共22,835股美國存託股份的購股權。 授出購股權詳情 購股權詳情如下： | | | 相關股份數目： 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeiGene, Ltd. 百濟神州有限公司 （於開曼群島註冊成立的有限公司） （股份代號：06160） 授出購股權、受限制股份單位及業績股份單位 本公告乃根據上市規則第17.06A、17.06B以及17.06C條作出。於2024年8月9日， 董事會及╱或董事會薪酬委員會根據2016期權及激勵計劃的條款向五名承授人 授出可認購合共22,835股美國存託股份的購股權，向三百三十二名承授人授出涉 及合共87,399股美國存託股份的受限制股份單位，並向一名承授人授出涉及合共 9,119股美國存託股份的業績股份單位。 2016期權及激勵計劃項下的購股權 1 授出日期： 2024年8月9日 承授人數目： 五名 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 百濟神州有限公司（「本公司」）謹此公佈，本公司董事會（「董事會」）審計委員會 的會議將於2024年8月26日（美國東部時間）舉行，以（其中包括）審議及批准本公 司及其附屬公司截至2024年6月30日止六個月中期業績及根據香港聯合交易所有 限公司證券上市規則（「香港上市規則」）刊發中期業績。本公司先前於2024年8月 7日公佈其截至2024年6月30日止三個月及六個月的中期業績，並以提交表格10-Q 的方式將其季度業績送交美國證券交易委員會（「美國證券交易委員會」）存案。本 公司根據香港上市規則刊發的中期業績與本公司先前已公佈並送交美國證券交易 委員會存案者相同，惟根據香港上市規則所要求的指定附加資料及將本公司的中 期業績從美國公認會計原則與國際財務報表準則進行核對的結果除外。 於本公告日期，本公司董事會包括主席兼執行董事歐雷強先生、非執行董事王 曉東博士，以及獨立非執行董事Olivier Brandico ...

Investment Rating - The report maintains a "Buy" rating for both A-shares and H-shares of the company, with a target price of 180.24 CNY per share for A-shares and 200.27 HKD per share for H-shares [4]. Core Insights - The company reported a strong revenue growth of 65.4% year-on-year for the first half of 2024, reaching 11.996 billion CNY, while narrowing its net loss to 2.877 billion CNY [1]. - The core product, Baiyueze, saw global sales of 8.018 billion CNY in H1 2024, a significant increase of 122% year-on-year, with U.S. sales alone growing by 134.4% [1]. - The company has a rich pipeline of new drugs, with multiple candidates advancing through clinical trials, including Sonrotoclax and BGB-16673, which are in various stages of global registration [1]. Financial Summary - Revenue projections for the company are estimated at 25.177 billion CNY for 2024, 31.421 billion CNY for 2025, and 37.123 billion CNY for 2026, reflecting growth rates of 44.5%, 24.8%, and 18.1% respectively [2][3]. - The adjusted operating profit for Q2 2024 was reported at 345 million CNY, indicating improved operational efficiency driven by sales growth and cost management [1]. - The company is expected to continue narrowing its net losses, with projections of -2.876 billion CNY for 2024 and a potential return to profitability with a net profit of 1.759 billion CNY by 2026 [3].

证券研究报告·公司点评报告·生物制品 百济神州-U（688235） 2024 年 H1 业绩快报点评：核心产品放量超 预期，进入全球增长新阶段 2024 年 08 月 09 日 买入（维持） | --- | --- | --- | --- | --- | --- | |----------------------------|---------|--------|--------|--------|--------| | 盈利预测与估值 [Table_EPS] | 2022A | 2023A | 2024E | 2025E | 2026E | | 营业总收入（百万元） | 9,566 | 17,423 | 25,530 | 34,062 | 42,383 | | 同比（%） | 26% | 82% | 47% | 33% | 24% | | 归母净利润（百万元） | -13,642 | -6,716 | -3,116 | 274 | 636 | | 同比（%） | -40% | 51% | 54% | 109% | 132% | | EPS-最新摊薄（元/股） | -9.91 | -4.88 | -2.26 ...

美股代码：BGNE A 股代码：688235 A 股简称：百济神州 港股代码：06160 港股简称：百济神州 百济神州有限公司 投资者关系活动记录表 （2024 年 8 月） 投资者关系 √特定对象调研 □分析师会议 □媒体采访 □业绩说明会 活动类别 □新闻发布会 √路演活动 □现场参观 □一对一沟通 √其他（电话会议） 参与单位 3w 、 Ariose Capital 、 Balyasny Asset Management 、 Boyu 及人员 Captial 、 Capital Group 、 CSOP Asset Management 、 CTI Capital 、 Franklin Templeton Investments 、 Guotai Junan Assets Asia、HSBC GAM、IDG Capital、Invesco、Janchor Partners、Marshall Wace、New Silk Road、Point 72、SPDBI、Tiger Pacific Capital、安信基 金、奥昇投资、彼得明奇资管、财通资管、淳厚基金、大家资产、丹羿 投资、淡马锡、淡水泉投资、道翼资 ...

医药生物 2024 年 08 月 08 日 百济神州 (688235) ——泽布替尼高速增长，二季度非 GAAP 经营利润盈利 | --- | |---------------------| | 2024 年 08 月 07 日 | | 137.50 | | 163.88/98.50 | | 7.8 | | - | | 15,820 | | 2,869.83/8,449.58 | | | | --- | --- | |--------------------------|---------------------| | 基础数据: | 2024 年 03 月 31 日 | | 每股净资产（元） | 17.76 | | 资产负债率% | 40.51 | | 总股本/流通 A 股（百万） | 1,376/115 | | 流通 B 股/H 股（百万） | -/1,261 | 一年内股价与大盘对比走势： 08-0709-0710-0711-0712-0701-0702-0703-0704-0705-0706-0707-0708-07 -40% -20% 0% 20% 40% 60% 百济神州 沪深300指数 (收益率 ...

Investment Rating - The report maintains a "Buy" rating for the company and raises the target price to USD 285, HKD 171, and CNY 181 [1][3]. Core Insights - The company's Q2 2024 performance significantly exceeded expectations, primarily driven by strong sales growth of Zebutinib in the US and Europe. The company achieved its first adjusted Non-GAAP operating profit, marking a positive surprise in this earnings report [1]. - Total revenue for Q2 2024 reached USD 929 million, representing a year-over-year increase of 56.1% and a quarter-over-quarter increase of 23.6%. Product revenue was USD 921 million, up 66.3% year-over-year and 23.2% quarter-over-quarter, significantly surpassing expectations [1]. - Zebutinib's global sales reached USD 637 million, with US sales at USD 479 million, reflecting a year-over-year increase of 114.4% and a quarter-over-quarter increase of 36.3%. The management indicated that Zebutinib has captured over 40% market share in the CLL indication in the US [1][3]. Summary by Sections Financial Performance - The company reported a net loss of USD 120 million for Q2 2024, a decrease of 68.4% year-over-year and 52.1% quarter-over-quarter, which was better than expectations due to stronger product revenue and higher gross margins [1]. - The overall product gross margin reached 85% in Q2 2024, up 2.3 percentage points year-over-year and 1.7 percentage points quarter-over-quarter [1]. Research and Development Progress - The company is focusing on key pipeline projects, including Sonrotoclax (BCL2) and BGB-16673 (BTK CDAC), with ongoing clinical trials and expected data readouts in late 2024 and early 2025 [1][3]. - The management anticipates further improvements in gross margins and a reduction in R&D and administrative expense ratios as Zebutinib sales continue to grow [1]. Market Position and Strategy - The company announced a relocation of its registered office from the Cayman Islands to Switzerland, reflecting its global strategic expansion [3]. - The establishment of a large-scale production facility in New Jersey is now operational, which will support the supply of its products in the US and Europe [3].

感谢和欢迎各位投资者和白金十字路的高管团队参与我们今天的小组会下面我们把时间交给中定的同事 我是中金的张静,感谢大家参加在基层洲的小组会每个采报之后公司也可以跟国内头部的企业机构分享公司的经营情况主要的亮点稍后公司可能会全面展开再讲其实在这边要讲一点就是关于提示当然今年年初以来到目前为止国内投资者对于创新一这个板块创新二这个板块其实非常非常关注7月也有一个重大成果的落地总理也批了 全链条支持创新和发展的实施方案那么一直在强调创新2.0的时期整个板块可能会出现分层国际化毫无疑问是一个比较重要的选择方向那百机也是我们国家我们国内国际化的一个先锋龙头那上半年的包括BGA放量的这个超预期以及后续管线的一个布局其实都是非常值得期待的那么在结构分层的这个过程当中希望各位投资者把握头部的 在下一阶段这个发展过程当中,应该会有比较大的一个收获。那我就先讲到这里,先把时间交给公司领导。好嘞,张博远,我们现在开始。能听见吗?我说话。张博远,您可以开始,谢谢。 大家早上好,非常高兴,我看咱们上来了非常多的人,所以这个summarize来我们一块的话,我们尽量简短,把更多的时间留给大家来问问题。同时几个highlight,我觉得跟大 ...

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 II. 已發行股份及/或庫存股份變動 截至月份: 2024年7月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 百濟神州有限公司（於開曼群島註冊成立的有限公司） 呈交日期: 2024年8月6日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06160 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 9,500,000,000 | USD | 0.0001 | USD | | 950,000 | | 增加 / 減少 (-) | | | 0 | | | USD | | 0 | | 本月底結存 | | | 9,500,000,000 | USD | 0.0001 | USD | ...