Core Insights - Zacks Premium provides various tools to help investors make informed decisions and invest confidently in the stock market [1][2] Zacks Style Scores - Zacks Style Scores are indicators that assist investors in selecting stocks likely to outperform the market within 30 days, rated from A to F based on value, growth, and momentum characteristics [3] - The Value Score focuses on identifying undervalued stocks using financial ratios like P/E and Price/Sales [4] - The Growth Score evaluates a company's financial health and future outlook through projected earnings and sales [5] - The Momentum Score identifies optimal times to invest based on price trends and earnings estimate changes [6] - The VGM Score combines all three Style Scores, providing a comprehensive assessment of stocks based on value, growth, and momentum [7] Zacks Rank - The Zacks Rank is a proprietary model that uses earnings estimate revisions to simplify portfolio building, with 1 (Strong Buy) stocks achieving an average annual return of +25.41% since 1988, significantly outperforming the S&P 500 [8][9] - Investors are encouraged to select stocks with a Zacks Rank of 1 or 2 and Style Scores of A or B to maximize returns [10] Stock Example: Pfizer (PFE) - Pfizer operates in the biopharmaceutical sector, offering a range of drugs and vaccines, and currently holds a 3 (Hold) Zacks Rank with a VGM Score of A [12] - The stock has a Momentum Style Score of B, with a recent 0.3% increase in share price over the past four weeks, and upward revisions in earnings estimates for fiscal 2024 [13]

Core Viewpoint - Analysts project Pfizer's quarterly earnings to be $0.48 per share, reflecting a 380% year-over-year increase, with revenues expected to reach $17.5 billion, a 22.8% increase from the same quarter last year [1]. Earnings Estimates - The consensus EPS estimate has been revised downward by 3% over the past 30 days, indicating a collective reassessment by analysts [2]. - Revisions to earnings estimates are crucial indicators for predicting investor actions regarding the stock, with empirical research showing a strong correlation between earnings estimate trends and short-term stock performance [3]. Revenue Projections - Analysts estimate 'Pfizer Biopharma- Worldwide' revenues at $17.00 billion, indicating a year-over-year change of +22.6% [5]. - 'Revenues- Specialty Care- Vyndaqel family- Worldwide' are projected to reach $1.52 billion, reflecting a +57.9% year-over-year change [5]. - 'Revenues- Primary Care- Comirnaty direct sales and alliance revenues- Worldwide' are expected to be $3.27 billion, showing a -39.1% year-over-year change [6]. - 'Revenue- Primary Care- Nurtec ODT/Vydura- Worldwide' is projected at $384.55 million, indicating a +36.4% year-over-year change [6]. Regional Revenue Insights - 'Pfizer Biopharma- United States' is estimated at $9.29 billion, reflecting a +106.8% change from the year-ago quarter [7]. - 'Pfizer Biopharma- Total International' is projected to reach $7.71 billion, indicating a -17.7% change from the prior-year quarter [7]. - 'Revenue- Primary Care- Comirnaty direct sales and alliance revenues- Total International' is expected to be $2.43 billion, showing a -43.4% year-over-year change [8]. - 'Revenue- Primary Care- Paxlovid- Total International' is projected at $214.42 million, indicating an +88.1% year-over-year change [8]. Additional Revenue Metrics - 'Revenue- Primary Care- Nurtec ODT/Vydura- United States' is expected to be $358.64 million, reflecting a +30.4% change from the year-ago quarter [9]. - 'Revenue- Primary Care- Nurtec ODT/Vydura- Total International' is projected to reach $25.91 million, indicating a +270.1% year-over-year change [9]. - The average prediction for 'Revenue- Primary Care- United States' is $4.14 billion, reflecting a +426.4% year-over-year change [10]. - 'Revenue- Primary Care- Total International' is expected to be $4.50 billion, indicating a -27.4% change from the year-ago quarter [10]. Stock Performance - Pfizer shares have changed by +0.3% in the past month, compared to the Zacks S&P 500 composite's +1.2% move, with a Zacks Rank 3 (Hold) indicating expected performance closely aligned with the overall market [10].

Group 1 - The marketplace channel Haggerston BioHealth offers exclusive stock tips focused on Pharma, Biotech, and Healthcare, providing access to investment bank-grade financial models and research [1] - The group caters to both novice and experienced biotech investors, offering insights on catalysts, buy and sell ratings, product sales forecasts, and integrated financial statements [2] - Edmund Ingham, a biotech consultant with over 5 years of experience, leads the Haggerston BioHealth investing group and has compiled detailed reports on over 1,000 companies [2]

Core Viewpoint - Pfizer's shares increased nearly 3% following the news that activist investor Starboard did not nominate any directors to the board ahead of the January 25 deadline, indicating a less confrontational approach for this year [1] Group 1: Starboard's Influence - Starboard may attempt to make changes to Pfizer's board next year if no agreement is reached [2] - Starboard previously accused Pfizer's management of poor capital allocation, R&D failures, and issues with forecasting and budgeting, having built a $1 billion position in the company [3] - At an investor summit, Starboard publicly criticized Pfizer for not generating sustainable revenues from R&D and M&A activities [5] Group 2: Financial Performance and Market Value - Pfizer's shares have declined by 2.3% over the past year, while the industry has seen a growth of 0.2% [4] - Starboard highlighted that Pfizer has invested approximately $70 billion in acquisitions since the pandemic, claiming the company overpaid for these deals [7] - The decisions made by Pfizer have reportedly led to a loss of nearly $20-$60 billion in market value since 2019, despite a $40 billion boost from its COVID-19 franchise [8] Group 3: Capital Allocation Concerns - Starboard emphasized the importance of capital allocation discipline and requested the board to hold management accountable for incorrect capital allocation decisions [9]

Core Viewpoint - Pfizer is set to report its fourth-quarter and full-year 2024 earnings on February 4, with consensus estimates for sales at $17.50 billion and earnings at 48 cents per share, while 2025 earnings estimates have slightly declined from $2.92 to $2.88 per share [1][2]. Earnings Performance - Pfizer has consistently exceeded earnings expectations in the past four quarters, achieving an average earnings surprise of 74.50%, with the last quarter showing a surprise of 65.62% [2][3]. Revenue Estimates - The Zacks Consensus Estimate for direct sales and alliance revenues from the COVID-19 vaccine Comirnaty is $3.27 billion, while Paxlovid is estimated at $589.0 million [7]. - Non-COVID operational revenues have improved, with estimates for Vyndaqel/Vyndamax sales at $1.52 billion and Eliquis alliance revenues at $1.66 billion [8][9]. - Sales for the Prevnar family of vaccines are estimated at $1.56 billion, while the model estimates are slightly lower at $1.53 billion [10]. Product Performance - Sales of key oncology products like Ibrance may have declined due to competitive pressures, but other products such as Xtandi and Padcev are expected to have performed well [11]. - Newly launched drugs and acquisitions are anticipated to contribute positively to top-line growth, with several new therapies expected to drive revenue [12]. Stock Performance and Valuation - Pfizer's stock has decreased by 12.6% over the past six months, slightly better than the industry average decline of 13.0% [14]. - The stock is trading at a forward P/E ratio of 9.28, which is lower than the industry average of 16.0 and its own 5-year mean of 11.22, indicating attractive valuation [16]. Future Outlook - Pfizer expects a revenue CAGR of approximately 6% from 2025 to 2030, driven by new products and acquisitions [19]. - The company maintains a strong cash position from COVID product profits, which supports dividends, share buybacks, and debt reduction [22].

Core Insights - Pfizer Inc. announced results from the Phase 3 BREAKWATER trial for Braftovi (encorafenib) in combination with cetuximab and mFOLFOX6 for metastatic colorectal cancer with a BRAF V600E mutation [1][6] Efficacy Results - The Braftovi combination regimen showed a significant improvement in confirmed objective response rate (ORR) at 60.9% compared to 40.0% for chemotherapy with or without bevacizumab [2] - The estimated median duration of response was 13.9 months for the Braftovi combination versus 11.1 months for chemotherapy [3] - Among patients receiving Braftovi plus cetuximab and mFOLFOX6, 22.4% had a response lasting 12 months or longer, compared to 11.4% with chemotherapy [4] - The median time to response was 7.1 weeks for the Braftovi combination and 7.3 weeks for chemotherapy [4] Overall Survival Data - Overall survival (OS) data were immature but indicated a trend favoring the Braftovi combination over chemotherapy [5] - Median overall survival was not estimable for the Braftovi combination, while it was 14.6 months for chemotherapy [5] - The BREAKWATER trial is ongoing, with progression-free survival (PFS) results expected in 2025 [5] Safety Profile - The safety profile of Braftovi in combination with cetuximab and mFOLFOX6 was consistent with known safety profiles, with no new safety signals identified [6] - The FDA granted accelerated approval for Braftovi in combination with cetuximab and mFOLFOX6 for BRAF V600E-mutant mCRC in December 2024 [6] Market Reaction - Following the announcement, Pfizer's stock increased by 2.76% to $26.81 [6]

Core Insights - Pfizer achieved a significant milestone in 2022 by generating $100 billion in annual sales, but has since experienced a decline in financial performance and stock price [1] - The company is working on improving its financial results, with hopes that consistent revenue and earnings growth could attract more investors [2] Financial Performance - Pfizer's revenue guidance for 2025 is projected to be between $61 billion and $64 billion, indicating flat growth compared to 2024 [3] - The adjusted earnings per share for 2025 is expected to be in the range of $2.80 to $3, reflecting a growth of 10% to 18% compared to 2024 [4] Pipeline Developments - Pfizer has made progress in clinical and regulatory areas, but recent product approvals have not led to significant sales increases [5] - The company is developing danuglipron, a potential oral weight management medication currently in phase 1 studies, which could positively impact stock performance if successful [6][7] - The anti-obesity market is currently very attractive, and Pfizer's efforts in this area may yield better investor reactions compared to other pipeline candidates [8] Future Outlook - There is uncertainty regarding Pfizer's performance in the near term, with expectations that financial results may not be outstanding [9] - The company is laying a foundation for future growth, particularly in oncology, and aims to reduce reliance on inconsistent coronavirus-related sales [10] Dividend Considerations - Pfizer is recognized as a strong dividend stock, offering a forward yield of approximately 6.5%, significantly higher than the S&P 500 average of 1.3% [11] - The company has increased its dividend payouts by 53.6% over the past decade, making it appealing for long-term investors seeking stable income [11]

Core Viewpoint - Pfizer's stock underperformed in 2024, losing about 5%, while the S&P 500 gained 23%, attributed to declining Covid-19 vaccine sales, falling profitability, and increased competition [1][3][5] Group 1: 2024 Performance Overview - Pfizer's sales excluding Covid-19 products grew in double digits over the last couple of quarters, with Vyndaqel sales up 66% year-over-year to $3.9 billion and Eliquis sales up 8% to $5.5 billion [3] - Total revenue for Pfizer reached $59.4 billion in the last twelve months, slightly above $58.5 billion in 2023, aided by the acquisition of Seagen [3] - Pfizer aims to achieve $4 billion in cost savings for 2024, with total debt declining from $71 billion in 2023 to $67 billion, while cash decreased from $13 billion to $10 billion [3] Group 2: Stock Performance and Valuation - PFE stock declined from $28 at the beginning of 2024 to around $27 by year-end, with a volatile performance over the last four years [5] - The stock is currently undervalued, estimated at $36 per share, reflecting a potential upside of around 40% from current levels, trading at 2.5x trailing revenues compared to an average P/S ratio of 3.1x over the last five years [6][9] Group 3: Outlook for 2025 - 2025 may see slight improvements in sales and earnings, but the blockbuster drug Xeljanz is set to lose patent protection, which could impact revenue [7] - Continued market share gains are expected for Vyndaqel, Abrysvo, and Eliquis, while Xtandi and Prevnar may face increased competition [8] - The updated Covid-19 vaccine Comirnaty has been approved, and its performance will be monitored in 2025 [8]

Group 1 - Pfizer has implemented significant transformative changes, including a revamped commercial strategy and new leadership, resulting in exceeding market share expectations and achieving $4 billion in savings along with an additional $1.5 billion in margin improvements [1][2] - The company has returned over $7 billion in dividends and allocated $4.5 billion towards debt repayment in the first nine months of the year [2] - Pfizer is facing a significant loss of exclusivity wave projected to reduce revenues by about $17-18 billion between 2026 and 2028, but expects acquired products to generate $20 billion in revenue by 2030 to offset these losses [3] Group 2 - The company is optimistic about future performance due to significant progress in 2024, despite underwhelming new product launches in 2023 [4] - Guidance for 2024 reflects uncertainty due to miscalculations in COVID-19 revenue and the transition of Paxlovid to a commercial model, with expectations for stable COVID revenues in 2025 [5] - Demand for Paxlovid closely tracks predictable COVID waves, and the company anticipates stability in its COVID business moving forward [6]

Key Points Company and Industry Overview 1. **Company**: Pfizer Inc. (NYSE:PFE) 2. **Industry**: Pharmaceuticals and Biotechnology 3. **Event**: 43rd Annual J.P. Morgan Healthcare Conference Call 4. **Date**: January 13, 2025 5. **Participants**: Albert Bourla (Chairman & CEO of Pfizer) and Chris Schott (JPMorgan) Performance and Priorities 1. **2023 Performance**: Pfizer achieved all five priorities set for 2023, including oncology, commercial engine turnaround, new product maximization, cost reduction, and capital allocation. 2. **Priorities Achievements**: - **Oncology**: Achieved goals, particularly with the acquisition of Seagen. - **Commercial Engine**: Turnaround successful. - **New Products**: Maximized new products. - **Cost Reduction**: Announced plans to reduce costs by $4 billion. - **Pipeline**: Pushed pipeline forward. - **Capital Allocation**: Focused on shareholder-friendly capital allocation. 3. **Integration of Seagen**: Successfully integrated Seagen, doubling the size of Pfizer's R&D. Transformational Changes 1. **Significant Transformative Changes**: Pfizer implemented significant transformative changes within the company. Future Outlook 1. **Focus on Pipeline**: Continued focus on pipeline and new product development. 2. **Capital Allocation**: Ongoing focus on shareholder-friendly capital allocation.