近日，长春高新（000661）(000661.SZ)在披露2024年年报后召开投资者电话交流会，吸引东吴证券、 格林基金、摩根士丹利、易方达基金等96家机构参与。会上，公司财务总监及董秘围绕2024年公司业绩 表现及业务经营情况展开了详细的介绍，尤其突出了金赛药业伏欣奇拜单抗等多个在研管线的进展。 具体而言，用于成年痛风性关节炎的伏欣奇拜单抗，作为有望成为国内首款获批上市的IL-1β单抗，其 Ⅲ期临床数据显示出急性发作期非劣于复方倍他米松的疼痛缓解功效和更优的安全性，以及缓解期在用 药12周及24周内对降低痛风复发风险的显著疗效。据公告，该药品粉剂及水针剂上市申报分别于2024年 4月及2025年1月获得受理，其粉剂预计今年内能够获批上市。 公司提及的另一在研化药1类新药GS1-144片，是公司自主研发的NK3R小分子拮抗剂，该产品作为绝经 期血管舒缩症的非激素口服疗法，可为患者提供更好的治疗选择。据悉，国内暂无该靶点药物上市，公 司的GS1-144片研发在境内已至Ⅱ期临床阶段，在澳洲处于I期临床阶段，在美国处于Ⅱ期临床试验申请 获得FDA默示许可状态。 GenSci120注射液同样值得关注。该药品是公司自主 ...

证券代码：000661 证券简称：长春高新 公告编号：2025-046 一、药品的基本情况 产品名称：伏欣奇拜单抗注射液 申请事项：境内生产药品注册临床试验 受理号：CXSL2500163 申请人：长春金赛药业有限责任公司 审批结论：经审查，同意本品开展临床试验 适应症：子宫内膜异位症 二、药品的其它情况 伏欣奇拜单抗注射液是金赛药业自主研发的治疗用生物制品 1 类新药，拟用 于子宫内膜异位症。子宫内膜异位症是一种常见的慢性系统性炎症性疾病，发病 率约 10%-15%，且易复发，需长期管理。伏欣奇拜单抗能够特异性阻断 IL-1β与 受体 IL-1R 的结合，从而阻断受体激活引起的下游信号通路的活化，起到治疗子 宫内膜异位症的作用，已在临床前动物模型中展现了良好的疗效。本次临床试验 申请获批可推动后续该产品临床开发并进一步满足患者的临床需求。 2025 年 1 月，伏欣奇拜单抗注射液拟用于成年痛风性关节炎急性发作患者 的上市申请已获得国家药品监督管理局受理。具体内容详见公司于 2025 年 1 月 25 日在巨潮资讯网披露的《关于伏欣奇拜单抗注射液上市申请获得受理的公告》 （公告编号 2025-010）。 1 ...

长春高新（000661）技术产业(集团)股份有限公司(以下简称"长春高新")近日发布2024年年报，公司实 现营业收入134.66亿元，较上年同期降低7.55%；实现归属于上市公司股东的净利润25.83亿元，较上年 同期降低43.01%。这是近十年来，长春高新营收和净利润首次均出现同比下滑。 长春高新主营业务为生物制药及中成药的研发、生产和销售，辅以房地产开发等业务，并形成了长春金 赛药业有限责任公司(以下简称"金赛药业")、长春百克生物科技股份公司(以下简称"百克生物")、吉林 华康药业股份有限公司(以下简称"华康药业")、长春高新房地产开发有限责任公司(以下简称"高新地 产")"四驾马车"的发展格局。2024年，这四大子公司中，有3家业绩均出现下滑。 "现金奶牛"金赛药业净利润下滑超40% 从收入结构来看，长春高新仍高度依赖子公司金赛药业的生长激素。2024年，金赛药业实现收入106.71 亿元，较上年同期降低3.73%，占长春高新总营收的比例达79.24%；实现归属于母公司所有者的净利润 26.78亿元，较上年同期降低40.67%。 金赛药业是全球少数拥有粉针剂、水针剂、长效水针剂三代生长激素产品的企业 ...

华夏时报（www.chinatimes.net.cn）记者 杨燕 北京报道 过去两年内，受生长激素行业集采和监管等消息影响，长春高新多次出现暴跌现象，股价已从2021年高点497.54 元/股跌至发稿前的85.24元/股，跌幅逾80%。 对于当下长春高新的投资者来说，得到一份营收、净利润增速同比下滑的"成绩单"，实在是一件意料之外，情理 之中的事情。 这是长春高新近20年来首次出现营收、净利润增速双双下滑，即使是在过去几年集采的重压下也未曾如此"狼 狈"。财报显示，长春高新过去一年实现营业收入及净利润分别为134.66亿元和25.83亿元，相比去年同期分别下降 了7.55%和43.01%。 一家营收过百亿元的公司，净利润降幅超过40%意味着公司利润的大大缩水。更值得注意的是，随着年报而来的 一季报同样延续了颓势，2025年长春高新营收及净利润再度双降，其中净利润同比降幅达44.95%。 "增长神话"破灭，"多元化"道路前途未卜 如果说年报的净利润跌四成是个坏消息的话，那么一季报的净利润同样下跌超40%可能意味着"坏消息"将延续成 为长春高新的常态了。 长春高新主营业务分为生物制品、疫苗、中成药和房地产四大板块 ...

没有永远的牛市，只有轮动的风口。这句话放在长春高新身上再合适不过。 中国家长对身高的追求是一大风潮，以往孩子发育期身高涨不动只能听之任之，而现在有了科技手段，没有人愿意子孙后代再矮人一头，因此产生了非常 多的打生长激素的需求。在其他方面听到"激素"二字很容易让人应激，但对"恐矮"的家长来说，这是救命稻草。 网上流传一组数据：过去35年，中国19岁青少年平均身高增幅全球领先，男孩平均长高8.1厘米，达到175.7厘米；女孩平均长高6.1厘米，达到163.5厘米。 那些身高表现不佳的孩子的父母，因而会更加焦虑。 而作为生长激素背后的重要供应者，十一年前研发出"金赛增"的长春高新，自然成为了最大的赢家之一，外界也喜欢称之为"长高"，寓意积极。 直到近期，再好的寓意也无法阻挡趋势的降临。一季度近45%的净利润跌幅，年报超43%的业绩下滑，昔日A股医药白马股、"东北药茅"开始经历近二十 年来的至暗时刻。 长春高新最出圈的一次是个暴富故事：曾经有个大妈在2008年买了5万块的长春高新，后来出国忘记了密码，直到2021年去销户时，猛然发现已经涨到了 500万。 如今业绩发布之后，这家曾凭借生长激素单品跻身千亿市值俱乐部的医 ...

Investment Rating - The investment rating for the company is "Buy-A" with a 6-month target price of 117.54 CNY per share [4][9]. Core Views - The company is currently undergoing an innovation transformation, which has led to short-term performance pressure. The revenue for 2024 decreased by 7.55% year-on-year to 13.466 billion CNY, and the net profit dropped by 43.01% to 2.583 billion CNY [2][3]. - The company has significantly increased its R&D investment, reaching 2.690 billion CNY in 2024, an increase of 11.20% year-on-year, which now accounts for 19.97% of its revenue [2][3]. - Several key innovative drug candidates are entering the commercialization phase, including applications for IL-1β monoclonal antibody and other products, indicating a positive outlook for future revenue growth [3]. Financial Summary - For 2024, the company reported a revenue of 13.466 billion CNY and a net profit of 2.583 billion CNY, with a projected revenue of 13.835 billion CNY and net profit of 2.821 billion CNY for 2025 [11]. - The earnings per share (EPS) for 2025 is estimated at 6.92 CNY, with a price-to-earnings (PE) ratio of 12.3 times [4][11]. - The company’s total market capitalization is approximately 34.79 billion CNY, with a circulating market capitalization of about 34.08 billion CNY [4].

Investment Rating - The investment rating for the company is maintained as "Buy" with a target price of 106.80 RMB [7][8]. Core Views - The company is in a period of innovation and transformation, expecting to see significant growth in the long term despite short-term revenue and profit declines [1][2]. - The revenue for 2024 is projected to be 13.466 billion RMB, a decrease of 7.6% year-on-year, with a net profit of 2.583 billion RMB, down 43.0% year-on-year [1]. - The company is expected to face challenges in 2025, with a projected net profit decline due to increased sales and management expenses during the transition period [1][5]. Summary by Sections Financial Performance - The company reported a revenue of 29.97 million RMB and a net profit of 4.73 million RMB in Q1 2025, reflecting a year-on-year decline of 5.7% and 45.0% respectively [1]. - For 2025, the expected earnings per share (EPS) is 5.34 RMB, with a projected net profit of 2.180 billion RMB, a decrease of 15.61% year-on-year [5][12]. Revenue Drivers - The growth in revenue is anticipated from the sales of long-acting growth hormones and the gradual release of non-growth hormone products [1][2]. - The overseas market is expected to show significant growth, with a projected increase of 454% year-on-year in 2024 [2]. Cost Structure - The company is experiencing rising sales, management, and R&D expenses due to its innovation transformation, which is expected to continue impacting profitability in the near term [1][12]. - The projected sales expenses for 2025 are estimated at 5.016 billion RMB, reflecting a 13.0% increase year-on-year [13]. Market Position - The company is focusing on expanding its product pipeline, particularly in children's nutrition and other therapeutic areas, which are expected to drive long-term growth [2][3]. - The company is also advancing its vaccine pipeline, with several products in various stages of development [3].

Summary of Changchun High-tech Conference Call Company Overview - **Company**: Changchun High-tech - **Key Subsidiaries**: Jinsai Pharmaceutical, Baike Biological, Huakang Pharmaceutical Financial Performance - **2024 Revenue**: 135 billion CNY, a 41% year-on-year decline - **Net Profit**: Decreased to less than 26 billion CNY, a 43% decline - **Jinsai Pharmaceutical**: Revenue of 106 billion CNY, net profit of 26.78 billion CNY, down 41% year-on-year - **Baike Biological**: Revenue of 12 billion CNY, net profit of 2.32 billion CNY, down 54% year-on-year - **Huakang Pharmaceutical**: Revenue of 7.62 billion CNY, net profit of 52 million CNY, up 39% year-on-year - **Real Estate Sector**: Revenue of 7.5 billion CNY, profit of 150 million CNY Research and Development - **R&D Investment**: 2.7 billion CNY in 2024, an 11% increase year-on-year - **Capitalized R&D**: 2.167 billion CNY, a 26% increase year-on-year - **Pipeline**: 24 products across 28 indications, with 9 innovative drugs entering clinical trials - **New Products**: Liquid follicle-stimulating hormone and progesterone launched, with 2025 approval expected for Liraglutide and Long-acting FSH Market Dynamics - **Long-acting Growth Hormone**: Market competition intensifying, with strategies to increase long-acting product share and improve hospital access - **Sales Structure**: Long-acting formulations increased to 32%, while powder and water formulations accounted for 11-12% and 56%, respectively Strategic Decisions - **Termination of Stock Incentive Plan**: Accelerated recognition of 55 million CNY in expenses - **US Market Project**: Termination of a complex clinical project, resulting in a full impairment of 133 million CNY Non-Growth Hormone Business - **Revenue**: Approximately 1 billion CNY from non-growth hormone products - **Key Products**: Ovulation induction revenue close to 400 million CNY, nutrition products around 290 million CNY, with a growth rate of nearly 60% - **Future Goals**: Different targets set for various lines, aiming for breakeven by year-end Future Outlook - **2025 Q1 Performance**: Jinsai Pharmaceutical grew by 6%, but profits declined due to increased R&D and sales personnel - **Pain Management Product**: Fuxing Xipai monoclonal antibody shows promising clinical data, with significant pain reduction and lower recurrence rates for gout - **PD-1 Agonist Development**: Progressing in four indications, with plans for clinical trials Additional Insights - **Employee Incentives**: Despite halting stock incentives, the company is considering share buybacks and other compensation methods to attract talent - **Real Estate Strategy**: Focus on inventory digestion and light asset transformation to mitigate risks and improve cash flow Conclusion - Changchun High-tech is navigating a challenging market environment with strategic adjustments in R&D, product offerings, and market positioning to maintain competitiveness and drive future growth.

Core Viewpoint - Changchun High-tech is undergoing a strategic transformation from a "single blockbuster" to "diversified innovation," which has led to short-term performance fluctuations but is expected to yield long-term benefits through increased innovation and product diversification [1][2]. Financial Performance - In 2024, Changchun High-tech reported operating revenue of 13.466 billion yuan, a year-on-year decrease of 7.55% - The net profit attributable to shareholders was 2.583 billion yuan, down 43.01% year-on-year - The net profit after deducting non-recurring gains and losses was 2.830 billion yuan, a decline of 37.32% year-on-year [1]. R&D Investment - The company increased its R&D investment to 2.690 billion yuan in 2024, an increase of 11.20% compared to the previous year, with R&D expenses accounting for 19.97% of operating revenue - R&D expenses reached 2.167 billion yuan, up 25.75% year-on-year [1]. Product Diversification - Changchun High-tech has developed a diverse product line with 24 key products covering 28 indications, including 9 Class 1 innovative drugs - The company aims to reduce reliance on single products through diversified layouts, which are already showing initial results [2]. AI Integration - The company has established an AI-enabled system covering the entire drug lifecycle, utilizing its self-developed AI platform GenMOL to enhance drug discovery and development efficiency - The AI-powered research assistant GenAIR has significantly improved drug R&D efficiency by integrating large language models with extensive literature databases [2][3]. Shareholder Returns - The profit distribution plan for 2024 includes a cash dividend of 26 yuan per 10 shares, totaling 1.047 billion yuan, which, combined with previous buybacks, represents 56.81% of the net profit - Since its listing, the company has distributed a total of 3.747 billion yuan in cash dividends and repurchased shares worth 1.220 billion yuan, amounting to 4.967 billion yuan, which is 159.25% of the total cash raised excluding mergers and private placements [4]. International Expansion - Changchun High-tech is actively exploring international licensing cooperation for its innovative products and seeking partnerships with large international pharmaceutical companies - In 2024, overseas sales revenue for its subsidiary, Jinsai Pharmaceutical, saw a remarkable growth of 454%, with emerging markets like Algeria becoming significant growth drivers [5].

Core Viewpoint - Changchun High-tech's performance has significantly declined in 2024, marking the first annual net profit drop in nearly 11 years, primarily due to intensified competition in the growth hormone market and increased R&D and sales expenses [1][3][5]. Financial Performance - In 2024, Changchun High-tech reported revenue of approximately 13.466 billion yuan, a year-on-year decrease of 7.55%, and a net profit of about 2.583 billion yuan, down 43.01% [3][6]. - For Q1 2025, the company continued to experience declines, with revenue of around 2.997 billion yuan, a decrease of 5.66%, and a net profit of approximately 473 million yuan, down 44.95% [3][6]. Key Subsidiary Performance - Changchun Jinsai Pharmaceutical, a major revenue source, saw its revenue drop to 10.671 billion yuan in 2024, a decline of 3.73%, and net profit fell to 2.678 billion yuan, down 40.67% [6][5]. - Another subsidiary, Baike Biological, also reported a decline in 2024, with revenue of 1.229 billion yuan, down 32.64%, and net profit of 232 million yuan, down 53.67% [7]. R&D and Sales Expenses - In 2024, R&D expenses reached 2.69 billion yuan, an increase of 11.2%, accounting for 19.97% of revenue, while sales expenses rose to 4.439 billion yuan, up 11.81% [8]. - The increase in R&D and sales expenses is attributed to accelerated new product development and enhanced sales team recruitment [8]. Market Competition - The growth hormone market has become increasingly competitive, with multiple companies entering the field, impacting Changchun Jinsai's market share [5][6]. - The company has acknowledged the need for continuous R&D investment to maintain product competitiveness amid rising competition [1][5]. R&D Personnel Changes - As of the end of 2024, the number of R&D personnel decreased to 1,264, with a notable increase in the number of PhD holders, which rose by 31.82% [9].